Nogo-A regulates myogenesis via interacting with Filamin-C

Sun Young Park, Ji Hwan Park, Un Beom Kang, Seong Kyoon Choi, Ahmed Elfadl, H. M.Arif Ullah, Myung Jin Chung, Ji Yoon Son, Hyun Ho Yun, Jae Min Park, Jae hyuk Yim, Seung Jun Jung, Sang Hyup Kim, Young Chul Choi, Dae Seong Kim, Jin Hong Shin, Jin Sung Park, Keun Hur, Sang Han Lee, Eun Joo LeeDaehee Hwang, Kyu Shik Jeong

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Among the three isoforms encoded by Rtn4, Nogo-A has been intensely investigated as a central nervous system inhibitor. Although Nogo-A expression is increased in muscles of patients with amyotrophic lateral sclerosis, its role in muscle homeostasis and regeneration is not well elucidated. In this study, we discovered a significant increase in Nogo-A expression in various muscle-related pathological conditions. Nogo−/− mice displayed dystrophic muscle structure, dysregulated muscle regeneration following injury, and altered gene expression involving lipid storage and muscle cell differentiation. We hypothesized that increased Nogo-A levels might regulate muscle regeneration. Differentiating myoblasts exhibited Nogo-A upregulation and silencing Nogo-A abrogated myoblast differentiation. Nogo-A interacted with filamin-C, suggesting a role for Nogo-A in cytoskeletal arrangement during myogenesis. In conclusion, Nogo-A maintains muscle homeostasis and integrity, and pathologically altered Nogo-A expression mediates muscle regeneration, suggesting Nogo-A as a novel target for the treatment of myopathies in clinical settings.

Original languageEnglish
Article number1
JournalCell Death Discovery
Issue number1
Publication statusPublished - 2021 Jun

Bibliographical note

Funding Information:
This research was supported by a grant of NRF-2017R1E1A1A01072781 from National Research Foundation of Korea and Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the Agri-Bioindustry Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) (312062-5), Republic of Korea.

Publisher Copyright:
© 2021, The Author(s).

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research


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