A non-aqueous capillary electrophoresis system for separating and detecting antidepressant drugs based on the coupling of capillary electrophoresis separation in acetonitrile and UV detection is described. The system offers a rapid simultaneous measurement in less than 12 min for six priority pyrimidoisoindoles. These antidepressants were detected down to the 2.5 × 10 -6-4.2 × 10 -6 mol/L level, with linearity up to the 1 × 10 -3 mol/L level examined. A highly stable response was observed for repetitive injections (R.S.D. < 2.6%, n = 12). The influence of pH and content of acetonitrile upon the electrophoretic mobilities was also studied.
|Number of pages||4|
|Journal||Journal of Separation Science|
|Publication status||Published - 2002 Jun 17|
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Filtration and Separation