Non-dippers are associated with adverse cardiac remodeling and dysfunction (R1)

Hye Sun Seo, Tae Soo Kang, Sungha Park, Eui Young Choi, Young Guk Ko, Donghoon Choi, Jongwon Ha, Se Joong Rim, Namsik Chung

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39 Citations (Scopus)

Abstract

Background: Non-dippers are known to carry a high risk of cardiovascular complications due to higher cumulative 24-h pressure load over time. In this study, we hypothesized that non-dippers would be associated with adverse cardiac remodeling and left ventricular (LV) dysfunction in treated hypertensive patients. Materials and methods: A total of 150 outpatients treated with antihypertensive drugs for at least 1 year were enrolled. The patients were classified as non-dippers if their daytime ambulatory systolic and diastolic BP did not decrease by at least 10% during the night. LV diastolic function was assessed by measuring mitral inflow velocity (E), early diastolic mitral annulus tissue velocity (E′) and LV systolic function was assessed by measuring systolic tissue velocity (S′), longitudinal systolic strain and strain rate. Results: The Cornell voltage product, LA volume index and LV mass index was significantly higher in non-dippers. Early diastolic mitral annulus tissue velocity (E′) was lower and E/E′ was higher in non-dippers suggestive of diastolic dysfunction. Systolic tissue velocity (S′), systolic strain and strain rate were significantly lower in non-dippers suggestive of systolic dysfunction. The non-dipper status, controlled for age, sex and LV mass index showed significant correlation with E′ (β = - 0.203, P = 0.002), E/E′ (β = 0.354, P < 0.001), S′ (β = - 0.231, P = 0.002), strain (β = - 0.162, P = 0.040) and strain rate (β = - 0.186, P = 0.015). Conclusions: This study showed the non-dippers in treated hypertensive patients were associated with adverse cardiac remodeling and early LV dysfunction. Further studies to demonstrate the long term prognostic significance of this finding is warranted.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalInternational Journal of Cardiology
Volume112
Issue number2
DOIs
Publication statusPublished - 2006 Sep 20

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Left Ventricular Dysfunction
Left Ventricular Function
Antihypertensive Agents
Outpatients
Pressure

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Seo, Hye Sun ; Soo Kang, Tae ; Park, Sungha ; Young Choi, Eui ; Ko, Young Guk ; Choi, Donghoon ; Ha, Jongwon ; Rim, Se Joong ; Chung, Namsik. / Non-dippers are associated with adverse cardiac remodeling and dysfunction (R1). In: International Journal of Cardiology. 2006 ; Vol. 112, No. 2. pp. 171-177.
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abstract = "Background: Non-dippers are known to carry a high risk of cardiovascular complications due to higher cumulative 24-h pressure load over time. In this study, we hypothesized that non-dippers would be associated with adverse cardiac remodeling and left ventricular (LV) dysfunction in treated hypertensive patients. Materials and methods: A total of 150 outpatients treated with antihypertensive drugs for at least 1 year were enrolled. The patients were classified as non-dippers if their daytime ambulatory systolic and diastolic BP did not decrease by at least 10{\%} during the night. LV diastolic function was assessed by measuring mitral inflow velocity (E), early diastolic mitral annulus tissue velocity (E′) and LV systolic function was assessed by measuring systolic tissue velocity (S′), longitudinal systolic strain and strain rate. Results: The Cornell voltage product, LA volume index and LV mass index was significantly higher in non-dippers. Early diastolic mitral annulus tissue velocity (E′) was lower and E/E′ was higher in non-dippers suggestive of diastolic dysfunction. Systolic tissue velocity (S′), systolic strain and strain rate were significantly lower in non-dippers suggestive of systolic dysfunction. The non-dipper status, controlled for age, sex and LV mass index showed significant correlation with E′ (β = - 0.203, P = 0.002), E/E′ (β = 0.354, P < 0.001), S′ (β = - 0.231, P = 0.002), strain (β = - 0.162, P = 0.040) and strain rate (β = - 0.186, P = 0.015). Conclusions: This study showed the non-dippers in treated hypertensive patients were associated with adverse cardiac remodeling and early LV dysfunction. Further studies to demonstrate the long term prognostic significance of this finding is warranted.",
author = "Seo, {Hye Sun} and {Soo Kang}, Tae and Sungha Park and {Young Choi}, Eui and Ko, {Young Guk} and Donghoon Choi and Jongwon Ha and Rim, {Se Joong} and Namsik Chung",
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Non-dippers are associated with adverse cardiac remodeling and dysfunction (R1). / Seo, Hye Sun; Soo Kang, Tae; Park, Sungha; Young Choi, Eui; Ko, Young Guk; Choi, Donghoon; Ha, Jongwon; Rim, Se Joong; Chung, Namsik.

In: International Journal of Cardiology, Vol. 112, No. 2, 20.09.2006, p. 171-177.

Research output: Contribution to journalArticle

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T1 - Non-dippers are associated with adverse cardiac remodeling and dysfunction (R1)

AU - Seo, Hye Sun

AU - Soo Kang, Tae

AU - Park, Sungha

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AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Ha, Jongwon

AU - Rim, Se Joong

AU - Chung, Namsik

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N2 - Background: Non-dippers are known to carry a high risk of cardiovascular complications due to higher cumulative 24-h pressure load over time. In this study, we hypothesized that non-dippers would be associated with adverse cardiac remodeling and left ventricular (LV) dysfunction in treated hypertensive patients. Materials and methods: A total of 150 outpatients treated with antihypertensive drugs for at least 1 year were enrolled. The patients were classified as non-dippers if their daytime ambulatory systolic and diastolic BP did not decrease by at least 10% during the night. LV diastolic function was assessed by measuring mitral inflow velocity (E), early diastolic mitral annulus tissue velocity (E′) and LV systolic function was assessed by measuring systolic tissue velocity (S′), longitudinal systolic strain and strain rate. Results: The Cornell voltage product, LA volume index and LV mass index was significantly higher in non-dippers. Early diastolic mitral annulus tissue velocity (E′) was lower and E/E′ was higher in non-dippers suggestive of diastolic dysfunction. Systolic tissue velocity (S′), systolic strain and strain rate were significantly lower in non-dippers suggestive of systolic dysfunction. The non-dipper status, controlled for age, sex and LV mass index showed significant correlation with E′ (β = - 0.203, P = 0.002), E/E′ (β = 0.354, P < 0.001), S′ (β = - 0.231, P = 0.002), strain (β = - 0.162, P = 0.040) and strain rate (β = - 0.186, P = 0.015). Conclusions: This study showed the non-dippers in treated hypertensive patients were associated with adverse cardiac remodeling and early LV dysfunction. Further studies to demonstrate the long term prognostic significance of this finding is warranted.

AB - Background: Non-dippers are known to carry a high risk of cardiovascular complications due to higher cumulative 24-h pressure load over time. In this study, we hypothesized that non-dippers would be associated with adverse cardiac remodeling and left ventricular (LV) dysfunction in treated hypertensive patients. Materials and methods: A total of 150 outpatients treated with antihypertensive drugs for at least 1 year were enrolled. The patients were classified as non-dippers if their daytime ambulatory systolic and diastolic BP did not decrease by at least 10% during the night. LV diastolic function was assessed by measuring mitral inflow velocity (E), early diastolic mitral annulus tissue velocity (E′) and LV systolic function was assessed by measuring systolic tissue velocity (S′), longitudinal systolic strain and strain rate. Results: The Cornell voltage product, LA volume index and LV mass index was significantly higher in non-dippers. Early diastolic mitral annulus tissue velocity (E′) was lower and E/E′ was higher in non-dippers suggestive of diastolic dysfunction. Systolic tissue velocity (S′), systolic strain and strain rate were significantly lower in non-dippers suggestive of systolic dysfunction. The non-dipper status, controlled for age, sex and LV mass index showed significant correlation with E′ (β = - 0.203, P = 0.002), E/E′ (β = 0.354, P < 0.001), S′ (β = - 0.231, P = 0.002), strain (β = - 0.162, P = 0.040) and strain rate (β = - 0.186, P = 0.015). Conclusions: This study showed the non-dippers in treated hypertensive patients were associated with adverse cardiac remodeling and early LV dysfunction. Further studies to demonstrate the long term prognostic significance of this finding is warranted.

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