Non-frozen preservation of mammalian tissue using green tea polyphenolic compounds

Dong Wook Han, Suong Hyu Hyon, Jong Chul Park, Ki Dong Park, Young Hwan Park, Han Ki Park

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

The number of tissue or organ transplants has increased substantially in recent years with the advances in surgical methods and the development of immunosuppressive agents. Ideally, tissues should be transplanted immediately from the donor to the recipient. However, this is not always possible, and the problem of tissue preservation is very important for ensuring a successful transplantation. Therefore, it is essential to develop storage solutions that can maintain the viability and function of the tissues or organs for longer periods. Recent improvements in tissue and organ harvesting techniques and cryopreservation have made it possible to store various kinds of allografts and subsequently use these grafts as alternatives for supply-limited autografts. Moreover, tissue engineering techniques and regenerative medicine have been explored as a potential method to restore natural tissue and repair lesions. Nevertheless, no optimal method for the cryopreservation of mammalian tissues or organs as well as tissue engineered products has been established. Also, current methods can result in a substantial loss of function and lead to damage and destruction of the cells and tissues. Green tea polyphenolic compounds (GTPC) are well known as a functional food with various bioactivities, such as anti-oxidative, anti-carcinogenic, anti-mutagenic, anti-inflammatory, anti-microbial and anti-viral activities. However, less attention has been paid to the effects of GTPC on the non-frozen preservation of mammalian cells and blood vessels. Furthermore, the mechanism of this preservation effect of GTPC is not clearly understood. This review was written on the basis of the hypothesis that the non-frozen preservation of mammalian cells or tissues might be involved in cell cycle control through the cytostatic activity of GTPC.

Original languageEnglish
Article numberR03
Pages (from-to)R18-R29
JournalBiomedical Materials
Volume1
Issue number1
DOIs
Publication statusPublished - 2006 Mar 1

Fingerprint

Polyphenolic compounds
Tissue Preservation
Tea
Tissue
Tissue Survival
Cryopreservation
Transplants
Tissue and Organ Harvesting
Cells
Functional Food
Regenerative Medicine
Autografts
Cytostatic Agents
Tissue Engineering
Immunosuppressive Agents
Cell Cycle Checkpoints
Allografts
Blood Vessels
Anti-Inflammatory Agents
Transplantation

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Han, Dong Wook ; Hyon, Suong Hyu ; Park, Jong Chul ; Dong Park, Ki ; Hwan Park, Young ; Park, Han Ki. / Non-frozen preservation of mammalian tissue using green tea polyphenolic compounds. In: Biomedical Materials. 2006 ; Vol. 1, No. 1. pp. R18-R29.
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abstract = "The number of tissue or organ transplants has increased substantially in recent years with the advances in surgical methods and the development of immunosuppressive agents. Ideally, tissues should be transplanted immediately from the donor to the recipient. However, this is not always possible, and the problem of tissue preservation is very important for ensuring a successful transplantation. Therefore, it is essential to develop storage solutions that can maintain the viability and function of the tissues or organs for longer periods. Recent improvements in tissue and organ harvesting techniques and cryopreservation have made it possible to store various kinds of allografts and subsequently use these grafts as alternatives for supply-limited autografts. Moreover, tissue engineering techniques and regenerative medicine have been explored as a potential method to restore natural tissue and repair lesions. Nevertheless, no optimal method for the cryopreservation of mammalian tissues or organs as well as tissue engineered products has been established. Also, current methods can result in a substantial loss of function and lead to damage and destruction of the cells and tissues. Green tea polyphenolic compounds (GTPC) are well known as a functional food with various bioactivities, such as anti-oxidative, anti-carcinogenic, anti-mutagenic, anti-inflammatory, anti-microbial and anti-viral activities. However, less attention has been paid to the effects of GTPC on the non-frozen preservation of mammalian cells and blood vessels. Furthermore, the mechanism of this preservation effect of GTPC is not clearly understood. This review was written on the basis of the hypothesis that the non-frozen preservation of mammalian cells or tissues might be involved in cell cycle control through the cytostatic activity of GTPC.",
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Han, DW, Hyon, SH, Park, JC, Dong Park, K, Hwan Park, Y & Park, HK 2006, 'Non-frozen preservation of mammalian tissue using green tea polyphenolic compounds', Biomedical Materials, vol. 1, no. 1, R03, pp. R18-R29. https://doi.org/10.1088/1748-6041/1/1/R03

Non-frozen preservation of mammalian tissue using green tea polyphenolic compounds. / Han, Dong Wook; Hyon, Suong Hyu; Park, Jong Chul; Dong Park, Ki; Hwan Park, Young; Park, Han Ki.

In: Biomedical Materials, Vol. 1, No. 1, R03, 01.03.2006, p. R18-R29.

Research output: Contribution to journalReview article

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AU - Han, Dong Wook

AU - Hyon, Suong Hyu

AU - Park, Jong Chul

AU - Dong Park, Ki

AU - Hwan Park, Young

AU - Park, Han Ki

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