Non-HDL cholesterol is a simple measure to analyze the total amount of proatherogenic lipoproteins in the blood and to predict development of cardiovascular disease. However, it is unclear whether non-HDL cholesterol has a relationship with incident type 2 diabetes. This study aimed to evaluate the association between non-HDL cholesterol and incident type 2 diabetes with a large-sample, community-based Korean cohort over a 12-year period. Among the 10,038 total participants, 7608 (3662 men and 3946 women) without diabetes were selected from the Korean Genome and Epidemiology Study (KoGES). Their non-HDL cholesterol level was divided into quartiles. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. In total, 1442 individuals (18.9%: 1442 of 7608) developed type 2 diabetes during the 12-year follow up period, with an incident rate of 3.0–5.0. Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes for the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables, including the HOMA-IR marker. Non-HDL cholesterol level at baseline could be a future predictor of type 2 diabetes even when prior glucose or insulin (HOMA-IR) levels are normal.
Bibliographical noteFunding Information:
The authors would like to thank the participants and survey staff of the Korean Genome and Epidemiology Study (KoGES) for their contributions to the present study. Conflicts of interest: All authors declare that they have no competing interests. All authors have read the journal's policy on conflicts of interest. All authors have read the journal's authorship agreement and the manuscript has been reviewed by and approved by all named authors. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector. Authors? contributions: I.H. Seo and Y.J. Lee formed the study concept and designed the study; collected, analyzed, and interpreted the data; wrote the first draft; and revised later drafts of the article. I.H. Seo, D.H Son, and H.S. Lee analyzed and interpreted the data and performed the statistical analysis. Y.J. Lee revised the article. All authors have approved the final manuscript.
© 2021 Elsevier Inc.
All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
- Physiology (medical)
- Biochemistry, medical