This study used magnetic resonance (MR) thermometry to investigate the temperature increases and thermal transfer that occur during plasmonic photothermal therapy (PTT) with gold nanorods (GNRs). An artificial tumor phantom made of agarose gel containing GNRs was heated by irradiation with an 808 nm laser. The MR thermometry visualized the conditions: a well-localized temperature distribution with suppressed thermal diffusion that depended on laser power and irradiation time. A tumor phantom model was implanted in mice, and MR thermometry evaluated the temperature change in the presence and absence of GNRs and the thermal transfer into the surrounding tissues. That experiment showed that MR thermometry can be a useful tool for monitoring PTT. These results suggest that MR temperature measurement could help to establish ideal laser irradiation conditions in GNR-mediated PTT, and that it has great potential for visualizing local photothermal induction and evaluating therapeutic effects.
|Number of pages||6|
|Journal||Current Applied Physics|
|Publication status||Published - 2023 Jan|
Bibliographical noteFunding Information:
We thank to Yeogyeong Lee of King's College London for proof of this manuscript. This study was supported by a National Research Foundation of Korea grant funded by the Korea government (NRF-2021R1A6A3A01086846 and Institute of Information & communications Technology Planning & evaluation(IITP) grant funded by the Korea government (MSIT) ( 2022-0-01044 , Development of terahertz wave-based real-time intelligent brain tumor diagnosis system and technology).
© 2022 Korean Physical Society
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Physics and Astronomy(all)