Non-invasive and depth-free temperature monitoring using MR thermometry in plasmonic photothermal therapy using gold nanorods

Seung Hyun Yang; Kiyoung Jeong; Jaemoon Yang; Hye Young Son; Jin Suck Suh; Yong Min Huh; Seung Jae Oh

doi:10.1016/j.cap.2022.10.004

Non-invasive and depth-free temperature monitoring using MR thermometry in plasmonic photothermal therapy using gold nanorods

Seung Hyun Yang, Kiyoung Jeong, Jaemoon Yang, Hye Young Son, Jin Suck Suh, Yong Min Huh, Seung Jae Oh

Department of Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

This study used magnetic resonance (MR) thermometry to investigate the temperature increases and thermal transfer that occur during plasmonic photothermal therapy (PTT) with gold nanorods (GNRs). An artificial tumor phantom made of agarose gel containing GNRs was heated by irradiation with an 808 nm laser. The MR thermometry visualized the conditions: a well-localized temperature distribution with suppressed thermal diffusion that depended on laser power and irradiation time. A tumor phantom model was implanted in mice, and MR thermometry evaluated the temperature change in the presence and absence of GNRs and the thermal transfer into the surrounding tissues. That experiment showed that MR thermometry can be a useful tool for monitoring PTT. These results suggest that MR temperature measurement could help to establish ideal laser irradiation conditions in GNR-mediated PTT, and that it has great potential for visualizing local photothermal induction and evaluating therapeutic effects.

Original language	English
Pages (from-to)	12-17
Number of pages	6
Journal	Current Applied Physics
Volume	45
DOIs	https://doi.org/10.1016/j.cap.2022.10.004
Publication status	Published - 2023 Jan

Bibliographical note

Funding Information:
We thank to Yeogyeong Lee of King's College London for proof of this manuscript. This study was supported by a National Research Foundation of Korea grant funded by the Korea government (NRF-2021R1A6A3A01086846 and Institute of Information & communications Technology Planning & evaluation(IITP) grant funded by the Korea government (MSIT) ( 2022-0-01044 , Development of terahertz wave-based real-time intelligent brain tumor diagnosis system and technology).

Publisher Copyright:
© 2022 Korean Physical Society

All Science Journal Classification (ASJC) codes

Materials Science(all)
Physics and Astronomy(all)

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10.1016/j.cap.2022.10.004

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title = "Non-invasive and depth-free temperature monitoring using MR thermometry in plasmonic photothermal therapy using gold nanorods",

abstract = "This study used magnetic resonance (MR) thermometry to investigate the temperature increases and thermal transfer that occur during plasmonic photothermal therapy (PTT) with gold nanorods (GNRs). An artificial tumor phantom made of agarose gel containing GNRs was heated by irradiation with an 808 nm laser. The MR thermometry visualized the conditions: a well-localized temperature distribution with suppressed thermal diffusion that depended on laser power and irradiation time. A tumor phantom model was implanted in mice, and MR thermometry evaluated the temperature change in the presence and absence of GNRs and the thermal transfer into the surrounding tissues. That experiment showed that MR thermometry can be a useful tool for monitoring PTT. These results suggest that MR temperature measurement could help to establish ideal laser irradiation conditions in GNR-mediated PTT, and that it has great potential for visualizing local photothermal induction and evaluating therapeutic effects.",

author = "Yang, {Seung Hyun} and Kiyoung Jeong and Jaemoon Yang and Son, {Hye Young} and Suh, {Jin Suck} and Huh, {Yong Min} and Oh, {Seung Jae}",

note = "Funding Information: We thank to Yeogyeong Lee of King's College London for proof of this manuscript. This study was supported by a National Research Foundation of Korea grant funded by the Korea government (NRF-2021R1A6A3A01086846 and Institute of Information & communications Technology Planning & evaluation(IITP) grant funded by the Korea government (MSIT) ( 2022-0-01044 , Development of terahertz wave-based real-time intelligent brain tumor diagnosis system and technology). Publisher Copyright: {\textcopyright} 2022 Korean Physical Society",

year = "2023",

month = jan,

doi = "10.1016/j.cap.2022.10.004",

language = "English",

volume = "45",

pages = "12--17",

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AU - Yang, Seung Hyun

AU - Jeong, Kiyoung

AU - Yang, Jaemoon

AU - Son, Hye Young

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Oh, Seung Jae

N1 - Funding Information: We thank to Yeogyeong Lee of King's College London for proof of this manuscript. This study was supported by a National Research Foundation of Korea grant funded by the Korea government (NRF-2021R1A6A3A01086846 and Institute of Information & communications Technology Planning & evaluation(IITP) grant funded by the Korea government (MSIT) ( 2022-0-01044 , Development of terahertz wave-based real-time intelligent brain tumor diagnosis system and technology). Publisher Copyright: © 2022 Korean Physical Society

PY - 2023/1

Y1 - 2023/1

N2 - This study used magnetic resonance (MR) thermometry to investigate the temperature increases and thermal transfer that occur during plasmonic photothermal therapy (PTT) with gold nanorods (GNRs). An artificial tumor phantom made of agarose gel containing GNRs was heated by irradiation with an 808 nm laser. The MR thermometry visualized the conditions: a well-localized temperature distribution with suppressed thermal diffusion that depended on laser power and irradiation time. A tumor phantom model was implanted in mice, and MR thermometry evaluated the temperature change in the presence and absence of GNRs and the thermal transfer into the surrounding tissues. That experiment showed that MR thermometry can be a useful tool for monitoring PTT. These results suggest that MR temperature measurement could help to establish ideal laser irradiation conditions in GNR-mediated PTT, and that it has great potential for visualizing local photothermal induction and evaluating therapeutic effects.

AB - This study used magnetic resonance (MR) thermometry to investigate the temperature increases and thermal transfer that occur during plasmonic photothermal therapy (PTT) with gold nanorods (GNRs). An artificial tumor phantom made of agarose gel containing GNRs was heated by irradiation with an 808 nm laser. The MR thermometry visualized the conditions: a well-localized temperature distribution with suppressed thermal diffusion that depended on laser power and irradiation time. A tumor phantom model was implanted in mice, and MR thermometry evaluated the temperature change in the presence and absence of GNRs and the thermal transfer into the surrounding tissues. That experiment showed that MR thermometry can be a useful tool for monitoring PTT. These results suggest that MR temperature measurement could help to establish ideal laser irradiation conditions in GNR-mediated PTT, and that it has great potential for visualizing local photothermal induction and evaluating therapeutic effects.

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Non-invasive and depth-free temperature monitoring using MR thermometry in plasmonic photothermal therapy using gold nanorods

Abstract

Bibliographical note

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