Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules

Jihyeon Lee, Won Seok Chang, Jaewoo Shin, Younghee Seo, Chanho Kong, Byeong Wook Song, Young Cheol Na, Bong Soo Kim, Jin Woo Chang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Although there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality for the treatment of brain diseases, including neurodegenerative disorders. The various biological effects of FUS treatment have been investigated; therefore, the goal is now to improve the delivery efficiency and function of MSCs by capitalizing on the advantages of FUS. In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.

Original languageEnglish
Article number101726
JournalStem Cell Research
Volume43
DOIs
Publication statusPublished - 2020 Mar

Bibliographical note

Funding Information:
We would like to acknowledge Dong-Su Jang, MFA (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine) for his help with our illustrations.

Funding Information:
This study was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning, Republic of Korea (2016M3C7A1914123), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI19C1234) and a faculty research grant of Yonsei University College of Medicine, Republic of Korea (6–2018–0032).

Publisher Copyright:
© 2020

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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