Non-mass breast lesions on ultrasound

Final outcomes and predictors of malignancy

Jong Won Park, Kyung Hee Ko, Eunkyung Kim, Cherie M. Kuzmiak, Hae Kyoung Jung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Breast cancer can present as non-mass lesions (NMLs) on ultrasound. However, knowledge of and understanding about NMLs are scarce. Purpose To retrospectively investigate the final outcomes of sonographic breast NMLs and determine the clinical and radiologic variables associated with malignancy Material and Methods In our radiologic database of breast ultrasound examinations between 2011 and 2014, we found 119 women with 121 NMLs with available histopathologic or sonographic follow-up (over 2 years) data. We collected the clinical variables (patient's age, symptoms, and mammographic density) and histopathologic data as well as radiologic variables (mammographic and ultrasound findings) after retrospective review by two radiologists, the authors of the current paper, in consensus. We classified the ultrasound findings according to distribution (focal, linear or segmental, and regional) and associated features (calcification, architectural distortion, and ductal changes) and analyzed the associations between variables and malignancy using the t test and χ 2 test. Results Of the 121 NMLs, 88 (72.7%) were benign and 33 (27.3%) were malignant. Ductal carcinoma in situ (DCIS) (17/33, 51.5%) and invasive ductal cancer with or without DCIS (13/33, 39.4%) comprised the main malignancies, and malignancy was significantly associated with palpability (P = 0.000). Mammographic findings and sonographic distribution and associated features were significantly different between benign and malignant lesions (P = 0.000, P = 0.004, and P = 0.001, respectively). Malignant lesions showed more frequent calcifications combined with asymmetry (P = 0.000) on mammography and linear-segmental distributions (P = 0.001) and associated calcifications (P = 0.019) or architectural distortions (P = 0.015) on ultrasound. Conclusion Breast NMLs on ultrasound showed high risk of malignancy. Symptoms and mammographic and ultrasound findings can be possible predictors of malignancy in NMLs.

Original languageEnglish
Pages (from-to)1054-1060
Number of pages7
JournalActa Radiologica
Volume58
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

Fingerprint

Breast
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Mammography
Databases
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Park, Jong Won ; Ko, Kyung Hee ; Kim, Eunkyung ; Kuzmiak, Cherie M. ; Jung, Hae Kyoung. / Non-mass breast lesions on ultrasound : Final outcomes and predictors of malignancy. In: Acta Radiologica. 2017 ; Vol. 58, No. 9. pp. 1054-1060.
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title = "Non-mass breast lesions on ultrasound: Final outcomes and predictors of malignancy",
abstract = "Background Breast cancer can present as non-mass lesions (NMLs) on ultrasound. However, knowledge of and understanding about NMLs are scarce. Purpose To retrospectively investigate the final outcomes of sonographic breast NMLs and determine the clinical and radiologic variables associated with malignancy Material and Methods In our radiologic database of breast ultrasound examinations between 2011 and 2014, we found 119 women with 121 NMLs with available histopathologic or sonographic follow-up (over 2 years) data. We collected the clinical variables (patient's age, symptoms, and mammographic density) and histopathologic data as well as radiologic variables (mammographic and ultrasound findings) after retrospective review by two radiologists, the authors of the current paper, in consensus. We classified the ultrasound findings according to distribution (focal, linear or segmental, and regional) and associated features (calcification, architectural distortion, and ductal changes) and analyzed the associations between variables and malignancy using the t test and χ 2 test. Results Of the 121 NMLs, 88 (72.7{\%}) were benign and 33 (27.3{\%}) were malignant. Ductal carcinoma in situ (DCIS) (17/33, 51.5{\%}) and invasive ductal cancer with or without DCIS (13/33, 39.4{\%}) comprised the main malignancies, and malignancy was significantly associated with palpability (P = 0.000). Mammographic findings and sonographic distribution and associated features were significantly different between benign and malignant lesions (P = 0.000, P = 0.004, and P = 0.001, respectively). Malignant lesions showed more frequent calcifications combined with asymmetry (P = 0.000) on mammography and linear-segmental distributions (P = 0.001) and associated calcifications (P = 0.019) or architectural distortions (P = 0.015) on ultrasound. Conclusion Breast NMLs on ultrasound showed high risk of malignancy. Symptoms and mammographic and ultrasound findings can be possible predictors of malignancy in NMLs.",
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Non-mass breast lesions on ultrasound : Final outcomes and predictors of malignancy. / Park, Jong Won; Ko, Kyung Hee; Kim, Eunkyung; Kuzmiak, Cherie M.; Jung, Hae Kyoung.

In: Acta Radiologica, Vol. 58, No. 9, 01.09.2017, p. 1054-1060.

Research output: Contribution to journalArticle

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T1 - Non-mass breast lesions on ultrasound

T2 - Final outcomes and predictors of malignancy

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AU - Kim, Eunkyung

AU - Kuzmiak, Cherie M.

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N2 - Background Breast cancer can present as non-mass lesions (NMLs) on ultrasound. However, knowledge of and understanding about NMLs are scarce. Purpose To retrospectively investigate the final outcomes of sonographic breast NMLs and determine the clinical and radiologic variables associated with malignancy Material and Methods In our radiologic database of breast ultrasound examinations between 2011 and 2014, we found 119 women with 121 NMLs with available histopathologic or sonographic follow-up (over 2 years) data. We collected the clinical variables (patient's age, symptoms, and mammographic density) and histopathologic data as well as radiologic variables (mammographic and ultrasound findings) after retrospective review by two radiologists, the authors of the current paper, in consensus. We classified the ultrasound findings according to distribution (focal, linear or segmental, and regional) and associated features (calcification, architectural distortion, and ductal changes) and analyzed the associations between variables and malignancy using the t test and χ 2 test. Results Of the 121 NMLs, 88 (72.7%) were benign and 33 (27.3%) were malignant. Ductal carcinoma in situ (DCIS) (17/33, 51.5%) and invasive ductal cancer with or without DCIS (13/33, 39.4%) comprised the main malignancies, and malignancy was significantly associated with palpability (P = 0.000). Mammographic findings and sonographic distribution and associated features were significantly different between benign and malignant lesions (P = 0.000, P = 0.004, and P = 0.001, respectively). Malignant lesions showed more frequent calcifications combined with asymmetry (P = 0.000) on mammography and linear-segmental distributions (P = 0.001) and associated calcifications (P = 0.019) or architectural distortions (P = 0.015) on ultrasound. Conclusion Breast NMLs on ultrasound showed high risk of malignancy. Symptoms and mammographic and ultrasound findings can be possible predictors of malignancy in NMLs.

AB - Background Breast cancer can present as non-mass lesions (NMLs) on ultrasound. However, knowledge of and understanding about NMLs are scarce. Purpose To retrospectively investigate the final outcomes of sonographic breast NMLs and determine the clinical and radiologic variables associated with malignancy Material and Methods In our radiologic database of breast ultrasound examinations between 2011 and 2014, we found 119 women with 121 NMLs with available histopathologic or sonographic follow-up (over 2 years) data. We collected the clinical variables (patient's age, symptoms, and mammographic density) and histopathologic data as well as radiologic variables (mammographic and ultrasound findings) after retrospective review by two radiologists, the authors of the current paper, in consensus. We classified the ultrasound findings according to distribution (focal, linear or segmental, and regional) and associated features (calcification, architectural distortion, and ductal changes) and analyzed the associations between variables and malignancy using the t test and χ 2 test. Results Of the 121 NMLs, 88 (72.7%) were benign and 33 (27.3%) were malignant. Ductal carcinoma in situ (DCIS) (17/33, 51.5%) and invasive ductal cancer with or without DCIS (13/33, 39.4%) comprised the main malignancies, and malignancy was significantly associated with palpability (P = 0.000). Mammographic findings and sonographic distribution and associated features were significantly different between benign and malignant lesions (P = 0.000, P = 0.004, and P = 0.001, respectively). Malignant lesions showed more frequent calcifications combined with asymmetry (P = 0.000) on mammography and linear-segmental distributions (P = 0.001) and associated calcifications (P = 0.019) or architectural distortions (P = 0.015) on ultrasound. Conclusion Breast NMLs on ultrasound showed high risk of malignancy. Symptoms and mammographic and ultrasound findings can be possible predictors of malignancy in NMLs.

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