Nonalcoholic fatty liver disease in diabetes. Part I: Epidemiology and diagnosis

Yong ho Lee, Yongin Cho, Byung Wan Lee, Cheol Young Park, Dae Ho Lee, Bong Soo Cha, Eun Jung Rhee

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This reciprocal relationship demonstrates the importance of confirming suspected NAFLD in patients with diabetes. Due to the invasive nature of liver biopsy to assess NAFLD status, various alternative non-invasive modalities have been developed and validated. Here, we summarized the epidemiology of NAFLD in patients with diabetes and reviewed currently available imaging modalities and biomarker-based prediction models for their ability to detect liver steatosis and/or fibrosis.

Original languageEnglish
Pages (from-to)31-45
Number of pages15
JournalDiabetes and Metabolism Journal
Volume43
Issue number1
DOIs
Publication statusPublished - 2019 Feb 1

Bibliographical note

Funding Information:
Editorial assistance was provided by Caron Modeas.

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

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