Nonculprit coronary plaque characteristics of chronic kidney disease

Koji Kato, Taishi Yonetsu, Haibo Jia, Farhad Abtahian, Rocco Vergallo, Sining Hu, Jinwei Tian, Soo Joong Kim, Hang Lee, Iris McNulty, Stephen Lee, Shiro Uemura, Yangsoo Jang, Seung Jung Park, Kyoichi Mizuno, Bo Yu, Ik Kyung Jang

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Abstract

Background: Chronic kidney disease (CKD) promotes the development of atherosclerosis and increases the risk of cardiovascular disease. The aim of the present study was to compare the coronary plaque characteristics of patients with and without CKD using optical coherence tomography. Methods and Results: We identified 463 nonculprit plaques from 287 patients from the Massachusetts General Hospital (MGH) optical coherence tomography registry. CKD was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m2. A total of 402 plaques (250 patients) were in the non-CKD group and 61 plaques (37 patients) were in the CKD group. Compared with non-CKD plaques, plaques with CKD had a larger lipid index (mean lipid arc×lipid length, 1248.4±782.8 mm° [non-CKD] versus 1716.1±1116.2 mm° [CKD]; P=0.003). Fibrous cap thickness was not significantly different between the groups. Calcification (34.8% [non-CKD] versus 50.8% [CKD]; P=0.041), cholesterol crystals (11.2% [non-CKD] versus 23.0% [CKD]; P=0.048), and plaque disruption (5.5% [non-CKD] versus 13.1% [CKD]; P=0.049) were more frequently observed in the CKD group. In the multivariate linear regression model, a lower estimated glomerular filtration rate and diabetes mellitus were independent risk factors for a larger lipid index. Conclusions: Compared with non-CKD patients, the patients with CKD had a larger lipid index with a higher prevalence of calcium, cholesterol crystals, and plaque disruption. The multivariate linear regression model demonstrated that a lower estimated glomerular filtration rate was an independent risk factor for a larger lipid index.

Original languageEnglish
Pages (from-to)448-456
Number of pages9
JournalCirculation: Cardiovascular Imaging
Volume6
Issue number3
DOIs
Publication statusPublished - 2013 May 1

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Chronic Renal Insufficiency
Kidney Diseases
Linear Models
Lipids
Glomerular Filtration Rate
Optical Coherence Tomography
Cholesterol
General Hospitals
Registries
Atherosclerosis
Diabetes Mellitus
Cardiovascular Diseases
Calcium

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Kato, K., Yonetsu, T., Jia, H., Abtahian, F., Vergallo, R., Hu, S., ... Jang, I. K. (2013). Nonculprit coronary plaque characteristics of chronic kidney disease. Circulation: Cardiovascular Imaging, 6(3), 448-456. https://doi.org/10.1161/CIRCIMAGING.112.000165
Kato, Koji ; Yonetsu, Taishi ; Jia, Haibo ; Abtahian, Farhad ; Vergallo, Rocco ; Hu, Sining ; Tian, Jinwei ; Kim, Soo Joong ; Lee, Hang ; McNulty, Iris ; Lee, Stephen ; Uemura, Shiro ; Jang, Yangsoo ; Park, Seung Jung ; Mizuno, Kyoichi ; Yu, Bo ; Jang, Ik Kyung. / Nonculprit coronary plaque characteristics of chronic kidney disease. In: Circulation: Cardiovascular Imaging. 2013 ; Vol. 6, No. 3. pp. 448-456.
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abstract = "Background: Chronic kidney disease (CKD) promotes the development of atherosclerosis and increases the risk of cardiovascular disease. The aim of the present study was to compare the coronary plaque characteristics of patients with and without CKD using optical coherence tomography. Methods and Results: We identified 463 nonculprit plaques from 287 patients from the Massachusetts General Hospital (MGH) optical coherence tomography registry. CKD was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m2. A total of 402 plaques (250 patients) were in the non-CKD group and 61 plaques (37 patients) were in the CKD group. Compared with non-CKD plaques, plaques with CKD had a larger lipid index (mean lipid arc×lipid length, 1248.4±782.8 mm° [non-CKD] versus 1716.1±1116.2 mm° [CKD]; P=0.003). Fibrous cap thickness was not significantly different between the groups. Calcification (34.8{\%} [non-CKD] versus 50.8{\%} [CKD]; P=0.041), cholesterol crystals (11.2{\%} [non-CKD] versus 23.0{\%} [CKD]; P=0.048), and plaque disruption (5.5{\%} [non-CKD] versus 13.1{\%} [CKD]; P=0.049) were more frequently observed in the CKD group. In the multivariate linear regression model, a lower estimated glomerular filtration rate and diabetes mellitus were independent risk factors for a larger lipid index. Conclusions: Compared with non-CKD patients, the patients with CKD had a larger lipid index with a higher prevalence of calcium, cholesterol crystals, and plaque disruption. The multivariate linear regression model demonstrated that a lower estimated glomerular filtration rate was an independent risk factor for a larger lipid index.",
author = "Koji Kato and Taishi Yonetsu and Haibo Jia and Farhad Abtahian and Rocco Vergallo and Sining Hu and Jinwei Tian and Kim, {Soo Joong} and Hang Lee and Iris McNulty and Stephen Lee and Shiro Uemura and Yangsoo Jang and Park, {Seung Jung} and Kyoichi Mizuno and Bo Yu and Jang, {Ik Kyung}",
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Kato, K, Yonetsu, T, Jia, H, Abtahian, F, Vergallo, R, Hu, S, Tian, J, Kim, SJ, Lee, H, McNulty, I, Lee, S, Uemura, S, Jang, Y, Park, SJ, Mizuno, K, Yu, B & Jang, IK 2013, 'Nonculprit coronary plaque characteristics of chronic kidney disease', Circulation: Cardiovascular Imaging, vol. 6, no. 3, pp. 448-456. https://doi.org/10.1161/CIRCIMAGING.112.000165

Nonculprit coronary plaque characteristics of chronic kidney disease. / Kato, Koji; Yonetsu, Taishi; Jia, Haibo; Abtahian, Farhad; Vergallo, Rocco; Hu, Sining; Tian, Jinwei; Kim, Soo Joong; Lee, Hang; McNulty, Iris; Lee, Stephen; Uemura, Shiro; Jang, Yangsoo; Park, Seung Jung; Mizuno, Kyoichi; Yu, Bo; Jang, Ik Kyung.

In: Circulation: Cardiovascular Imaging, Vol. 6, No. 3, 01.05.2013, p. 448-456.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nonculprit coronary plaque characteristics of chronic kidney disease

AU - Kato, Koji

AU - Yonetsu, Taishi

AU - Jia, Haibo

AU - Abtahian, Farhad

AU - Vergallo, Rocco

AU - Hu, Sining

AU - Tian, Jinwei

AU - Kim, Soo Joong

AU - Lee, Hang

AU - McNulty, Iris

AU - Lee, Stephen

AU - Uemura, Shiro

AU - Jang, Yangsoo

AU - Park, Seung Jung

AU - Mizuno, Kyoichi

AU - Yu, Bo

AU - Jang, Ik Kyung

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Background: Chronic kidney disease (CKD) promotes the development of atherosclerosis and increases the risk of cardiovascular disease. The aim of the present study was to compare the coronary plaque characteristics of patients with and without CKD using optical coherence tomography. Methods and Results: We identified 463 nonculprit plaques from 287 patients from the Massachusetts General Hospital (MGH) optical coherence tomography registry. CKD was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m2. A total of 402 plaques (250 patients) were in the non-CKD group and 61 plaques (37 patients) were in the CKD group. Compared with non-CKD plaques, plaques with CKD had a larger lipid index (mean lipid arc×lipid length, 1248.4±782.8 mm° [non-CKD] versus 1716.1±1116.2 mm° [CKD]; P=0.003). Fibrous cap thickness was not significantly different between the groups. Calcification (34.8% [non-CKD] versus 50.8% [CKD]; P=0.041), cholesterol crystals (11.2% [non-CKD] versus 23.0% [CKD]; P=0.048), and plaque disruption (5.5% [non-CKD] versus 13.1% [CKD]; P=0.049) were more frequently observed in the CKD group. In the multivariate linear regression model, a lower estimated glomerular filtration rate and diabetes mellitus were independent risk factors for a larger lipid index. Conclusions: Compared with non-CKD patients, the patients with CKD had a larger lipid index with a higher prevalence of calcium, cholesterol crystals, and plaque disruption. The multivariate linear regression model demonstrated that a lower estimated glomerular filtration rate was an independent risk factor for a larger lipid index.

AB - Background: Chronic kidney disease (CKD) promotes the development of atherosclerosis and increases the risk of cardiovascular disease. The aim of the present study was to compare the coronary plaque characteristics of patients with and without CKD using optical coherence tomography. Methods and Results: We identified 463 nonculprit plaques from 287 patients from the Massachusetts General Hospital (MGH) optical coherence tomography registry. CKD was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m2. A total of 402 plaques (250 patients) were in the non-CKD group and 61 plaques (37 patients) were in the CKD group. Compared with non-CKD plaques, plaques with CKD had a larger lipid index (mean lipid arc×lipid length, 1248.4±782.8 mm° [non-CKD] versus 1716.1±1116.2 mm° [CKD]; P=0.003). Fibrous cap thickness was not significantly different between the groups. Calcification (34.8% [non-CKD] versus 50.8% [CKD]; P=0.041), cholesterol crystals (11.2% [non-CKD] versus 23.0% [CKD]; P=0.048), and plaque disruption (5.5% [non-CKD] versus 13.1% [CKD]; P=0.049) were more frequently observed in the CKD group. In the multivariate linear regression model, a lower estimated glomerular filtration rate and diabetes mellitus were independent risk factors for a larger lipid index. Conclusions: Compared with non-CKD patients, the patients with CKD had a larger lipid index with a higher prevalence of calcium, cholesterol crystals, and plaque disruption. The multivariate linear regression model demonstrated that a lower estimated glomerular filtration rate was an independent risk factor for a larger lipid index.

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U2 - 10.1161/CIRCIMAGING.112.000165

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