Nonimmunologic targets of immunosuppressive agents in podocytes

TaeHyun Yoo, Alessia Fornoni

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Proteinuria is a characteristic finding in glomerular diseases and is closely associated with renal outcomes. In addition, therapeutic interventions that reduce proteinuria improve renal prognosis. Accumulating evidence has demonstrated that podocytes act as key modulators of glomerular injury and proteinuria. The podocyte, or glomerular visceral epithelial cell, is a highly specialized and differentiated cell that forms interdigitated foot processes with neighboring podocytes, which are bridged together by an extracellular structure known as the "slit diaphragm" (SD). The SD acts as a size- and charge-selective barrier to plasma protein. Derangement of SD structure or loss of SD-associated protein results in podocyte injury and proteinuria. During the past decades, several immune-modulating agents have been used for the treatment of glomerular diseases and for the reduction of proteinuria. Interestingly, recent studies have demonstrated that immunosuppressive agents can have a direct effect on the SD-associated proteins and stabilize actin cytoskeleton in podocyte and have therefore introduced the concept of nonimmunologic mechanism of renoprotection by immunomodulators. This review focuses on the evidence that immuno-modulating agents directly target podocytes.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalKidney Research and Clinical Practice
Volume34
Issue number2
DOIs
Publication statusPublished - 2015 Jun 1

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Podocytes
Immunosuppressive Agents
Diaphragm
Proteinuria
Kidney
Wounds and Injuries
Immunologic Factors
Actin Cytoskeleton
Foot
Blood Proteins
Proteins

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Cite this

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Nonimmunologic targets of immunosuppressive agents in podocytes. / Yoo, TaeHyun; Fornoni, Alessia.

In: Kidney Research and Clinical Practice, Vol. 34, No. 2, 01.06.2015, p. 69-75.

Research output: Contribution to journalReview article

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AU - Fornoni, Alessia

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AB - Proteinuria is a characteristic finding in glomerular diseases and is closely associated with renal outcomes. In addition, therapeutic interventions that reduce proteinuria improve renal prognosis. Accumulating evidence has demonstrated that podocytes act as key modulators of glomerular injury and proteinuria. The podocyte, or glomerular visceral epithelial cell, is a highly specialized and differentiated cell that forms interdigitated foot processes with neighboring podocytes, which are bridged together by an extracellular structure known as the "slit diaphragm" (SD). The SD acts as a size- and charge-selective barrier to plasma protein. Derangement of SD structure or loss of SD-associated protein results in podocyte injury and proteinuria. During the past decades, several immune-modulating agents have been used for the treatment of glomerular diseases and for the reduction of proteinuria. Interestingly, recent studies have demonstrated that immunosuppressive agents can have a direct effect on the SD-associated proteins and stabilize actin cytoskeleton in podocyte and have therefore introduced the concept of nonimmunologic mechanism of renoprotection by immunomodulators. This review focuses on the evidence that immuno-modulating agents directly target podocytes.

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