Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI: A feasibility study

Zixin Deng; Zhaoyang Fan; Sang Eun Lee; Christopher Nguyen; Yibin Xie; Jianing Pang; Xiaoming Bi; Qi Yang; Byoung Wook Choi; Jung Sun Kim; Daniel Berman; Hyuk Jae Chang; Debiao Li

doi:10.1002/mrm.26579

Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI: A feasibility study

Zixin Deng, Zhaoyang Fan, Sang Eun Lee, Christopher Nguyen, Yibin Xie, Jianing Pang, Xiaoming Bi, Qi Yang, Byoung Wook Choi, Jung Sun Kim, Daniel Berman, Hyuk Jae Chang, Debiao Li

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Purpose: To investigate the feasibility of blood pressure difference measurement, ΔP, across the coronary artery using phase contrast (PC)-MRI for potential noninvasive assessment of the functional significance of coronary artery stenosis. Methods: Three-directional velocities in the coronary arteries acquired using 2D-PC-MRI were used with the Navier-Stokes equations to derive ΔP. Repeat phantom studies were performed to assess the reproducibility of flow velocity and ΔP. ΔP derived using PC-MRI (ΔP_MR) and that obtained using pressure transducer (ΔP_PT) were compared. Reproducibility of coronary flow velocity was assessed in healthy controls (n = 11). Patients with suspected coronary artery disease (n = 6) were studied to evaluate the feasibility of ΔP_MR measurement across a coronary stenosis. Results: Phantom: Good overall reproducibility of flow velocity and ΔP measurements and excellent correlation (ΔP_MR vs ΔP_PT) was observed: intraclass correlation (ICC) of 0.95(V_z), 0.72(V_x), 0.73(V_y), and 0.87(ΔP_MR) and R² = 0.94, respectively. Human: Good reproducibility of coronary flow velocity was observed: ICC of 0.94/0.95(V_z), 0.76/0.74(V_x), and 0.80/0.77(V_y) at cardiac phase 1/2. Significant (p = 0.025) increase in ΔP_MR was observed in patients (6.40 ± 4.43 mmHg) versus controls (0.70 ± 0.57 mmHg). Conclusion: ΔP_MR in the coronary arteries is feasible. Upon further validation using the invasive measure, ΔP_MR has the potential for noninvasive assessment of coronary artery stenosis. Magn Reson Med 77:529–537, 2017.

Original language	English
Pages (from-to)	529-537
Number of pages	9
Journal	Magnetic Resonance in Medicine
Volume	77
Issue number	2
DOIs	https://doi.org/10.1002/mrm.26579
Publication status	Published - 2017 Feb 1

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1002/mrm.26579

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Deng, Zixin ; Fan, Zhaoyang ; Lee, Sang Eun ; Nguyen, Christopher ; Xie, Yibin ; Pang, Jianing ; Bi, Xiaoming ; Yang, Qi ; Choi, Byoung Wook ; Kim, Jung Sun ; Berman, Daniel ; Chang, Hyuk Jae ; Li, Debiao. / Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI : A feasibility study. In: Magnetic Resonance in Medicine. 2017 ; Vol. 77, No. 2. pp. 529-537.

@article{7c2a14ed467142a5b8d430224c2d41d8,

title = "Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI: A feasibility study",

abstract = "Purpose: To investigate the feasibility of blood pressure difference measurement, ΔP, across the coronary artery using phase contrast (PC)-MRI for potential noninvasive assessment of the functional significance of coronary artery stenosis. Methods: Three-directional velocities in the coronary arteries acquired using 2D-PC-MRI were used with the Navier-Stokes equations to derive ΔP. Repeat phantom studies were performed to assess the reproducibility of flow velocity and ΔP. ΔP derived using PC-MRI (ΔPMR) and that obtained using pressure transducer (ΔPPT) were compared. Reproducibility of coronary flow velocity was assessed in healthy controls (n = 11). Patients with suspected coronary artery disease (n = 6) were studied to evaluate the feasibility of ΔPMR measurement across a coronary stenosis. Results: Phantom: Good overall reproducibility of flow velocity and ΔP measurements and excellent correlation (ΔPMR vs ΔPPT) was observed: intraclass correlation (ICC) of 0.95(Vz), 0.72(Vx), 0.73(Vy), and 0.87(ΔPMR) and R2 = 0.94, respectively. Human: Good reproducibility of coronary flow velocity was observed: ICC of 0.94/0.95(Vz), 0.76/0.74(Vx), and 0.80/0.77(Vy) at cardiac phase 1/2. Significant (p = 0.025) increase in ΔPMR was observed in patients (6.40 ± 4.43 mmHg) versus controls (0.70 ± 0.57 mmHg). Conclusion: ΔPMR in the coronary arteries is feasible. Upon further validation using the invasive measure, ΔPMR has the potential for noninvasive assessment of coronary artery stenosis. Magn Reson Med 77:529–537, 2017.",

author = "Zixin Deng and Zhaoyang Fan and Lee, {Sang Eun} and Christopher Nguyen and Yibin Xie and Jianing Pang and Xiaoming Bi and Qi Yang and Choi, {Byoung Wook} and Kim, {Jung Sun} and Daniel Berman and Chang, {Hyuk Jae} and Debiao Li",

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doi = "10.1002/mrm.26579",

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Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI : A feasibility study. / Deng, Zixin; Fan, Zhaoyang; Lee, Sang Eun; Nguyen, Christopher; Xie, Yibin; Pang, Jianing; Bi, Xiaoming; Yang, Qi; Choi, Byoung Wook; Kim, Jung Sun; Berman, Daniel; Chang, Hyuk Jae; Li, Debiao.

In: Magnetic Resonance in Medicine, Vol. 77, No. 2, 01.02.2017, p. 529-537.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI

T2 - A feasibility study

AU - Deng, Zixin

AU - Fan, Zhaoyang

AU - Lee, Sang Eun

AU - Nguyen, Christopher

AU - Xie, Yibin

AU - Pang, Jianing

AU - Bi, Xiaoming

AU - Yang, Qi

AU - Choi, Byoung Wook

AU - Kim, Jung Sun

AU - Berman, Daniel

AU - Chang, Hyuk Jae

AU - Li, Debiao

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Purpose: To investigate the feasibility of blood pressure difference measurement, ΔP, across the coronary artery using phase contrast (PC)-MRI for potential noninvasive assessment of the functional significance of coronary artery stenosis. Methods: Three-directional velocities in the coronary arteries acquired using 2D-PC-MRI were used with the Navier-Stokes equations to derive ΔP. Repeat phantom studies were performed to assess the reproducibility of flow velocity and ΔP. ΔP derived using PC-MRI (ΔPMR) and that obtained using pressure transducer (ΔPPT) were compared. Reproducibility of coronary flow velocity was assessed in healthy controls (n = 11). Patients with suspected coronary artery disease (n = 6) were studied to evaluate the feasibility of ΔPMR measurement across a coronary stenosis. Results: Phantom: Good overall reproducibility of flow velocity and ΔP measurements and excellent correlation (ΔPMR vs ΔPPT) was observed: intraclass correlation (ICC) of 0.95(Vz), 0.72(Vx), 0.73(Vy), and 0.87(ΔPMR) and R2 = 0.94, respectively. Human: Good reproducibility of coronary flow velocity was observed: ICC of 0.94/0.95(Vz), 0.76/0.74(Vx), and 0.80/0.77(Vy) at cardiac phase 1/2. Significant (p = 0.025) increase in ΔPMR was observed in patients (6.40 ± 4.43 mmHg) versus controls (0.70 ± 0.57 mmHg). Conclusion: ΔPMR in the coronary arteries is feasible. Upon further validation using the invasive measure, ΔPMR has the potential for noninvasive assessment of coronary artery stenosis. Magn Reson Med 77:529–537, 2017.

AB - Purpose: To investigate the feasibility of blood pressure difference measurement, ΔP, across the coronary artery using phase contrast (PC)-MRI for potential noninvasive assessment of the functional significance of coronary artery stenosis. Methods: Three-directional velocities in the coronary arteries acquired using 2D-PC-MRI were used with the Navier-Stokes equations to derive ΔP. Repeat phantom studies were performed to assess the reproducibility of flow velocity and ΔP. ΔP derived using PC-MRI (ΔPMR) and that obtained using pressure transducer (ΔPPT) were compared. Reproducibility of coronary flow velocity was assessed in healthy controls (n = 11). Patients with suspected coronary artery disease (n = 6) were studied to evaluate the feasibility of ΔPMR measurement across a coronary stenosis. Results: Phantom: Good overall reproducibility of flow velocity and ΔP measurements and excellent correlation (ΔPMR vs ΔPPT) was observed: intraclass correlation (ICC) of 0.95(Vz), 0.72(Vx), 0.73(Vy), and 0.87(ΔPMR) and R2 = 0.94, respectively. Human: Good reproducibility of coronary flow velocity was observed: ICC of 0.94/0.95(Vz), 0.76/0.74(Vx), and 0.80/0.77(Vy) at cardiac phase 1/2. Significant (p = 0.025) increase in ΔPMR was observed in patients (6.40 ± 4.43 mmHg) versus controls (0.70 ± 0.57 mmHg). Conclusion: ΔPMR in the coronary arteries is feasible. Upon further validation using the invasive measure, ΔPMR has the potential for noninvasive assessment of coronary artery stenosis. Magn Reson Med 77:529–537, 2017.

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