Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles

Courtney R. Thomas, Daniel P. Ferris, Jae-Hyun Lee, Eunjoo Choi, Mi Hyeon Cho, Eun Sook Kim, J. Fraser Stoddart, Jeon Soo Shin, Jinwoo Cheon, Jeffrey I. Zink

Research output: Contribution to journalArticle

468 Citations (Scopus)

Abstract

Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties.

Original languageEnglish
Pages (from-to)10623-10625
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number31
DOIs
Publication statusPublished - 2010 Aug 11

Fingerprint

Nanoparticles
Nanocrystals
Silicon Dioxide
Molecules
Magnetic Fields
Drug Delivery Systems
Rotaxanes
Silica
Pharmaceutical Preparations
Controlled drug delivery
Magnetic fields
Cell death
Iron oxides
Nanostructured materials
Doxorubicin
Nanostructures
Zinc
Cells
Heating
Cell Death

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Thomas, Courtney R. ; Ferris, Daniel P. ; Lee, Jae-Hyun ; Choi, Eunjoo ; Cho, Mi Hyeon ; Kim, Eun Sook ; Stoddart, J. Fraser ; Shin, Jeon Soo ; Cheon, Jinwoo ; Zink, Jeffrey I. / Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 31. pp. 10623-10625.
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Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles. / Thomas, Courtney R.; Ferris, Daniel P.; Lee, Jae-Hyun; Choi, Eunjoo; Cho, Mi Hyeon; Kim, Eun Sook; Stoddart, J. Fraser; Shin, Jeon Soo; Cheon, Jinwoo; Zink, Jeffrey I.

In: Journal of the American Chemical Society, Vol. 132, No. 31, 11.08.2010, p. 10623-10625.

Research output: Contribution to journalArticle

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