Nonmuscle myosin II localization is regulated by JNK during Drosophila larval wound healing

Young Chang Kwon, Seung Hee Baek, Hyangkyu Lee, Kwang-Min Choe

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We investigated cell shape changes during wound closure in the Drosophila larval epidermis. During reepithelialization, epidermal cells permanently change shape from pentagonal or hexagonal to irregular forms. This process requires zipper, a gene encoding the Drosophila nonmuscle myosin II heavy chain. Following wounding, myosin II is localized at the wound margin and at the rear end of individual cells located within several rows from the wound hole. The c-Jun N-terminal kinase (JNK) pathway is essential for this myosin II localization. These results suggest that not only the wound leading edge but also the cells lying distal to the leading edge cells actively participate in epithelial cell sheet migration during wound hole closure.

Original languageEnglish
Pages (from-to)656-661
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume393
Issue number4
DOIs
Publication statusPublished - 2010 Mar 19

Fingerprint

Myosin Type II
JNK Mitogen-Activated Protein Kinases
Wound Healing
Drosophila
Wounds and Injuries
Gene encoding
Fasteners
Myosin Heavy Chains
Cell Shape
Epidermis
Cell Movement
Epithelial Cells
Genes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

@article{eede48fdcad64f88b88d6e6a986d38a8,
title = "Nonmuscle myosin II localization is regulated by JNK during Drosophila larval wound healing",
abstract = "We investigated cell shape changes during wound closure in the Drosophila larval epidermis. During reepithelialization, epidermal cells permanently change shape from pentagonal or hexagonal to irregular forms. This process requires zipper, a gene encoding the Drosophila nonmuscle myosin II heavy chain. Following wounding, myosin II is localized at the wound margin and at the rear end of individual cells located within several rows from the wound hole. The c-Jun N-terminal kinase (JNK) pathway is essential for this myosin II localization. These results suggest that not only the wound leading edge but also the cells lying distal to the leading edge cells actively participate in epithelial cell sheet migration during wound hole closure.",
author = "Kwon, {Young Chang} and Baek, {Seung Hee} and Hyangkyu Lee and Kwang-Min Choe",
year = "2010",
month = "3",
day = "19",
doi = "10.1016/j.bbrc.2010.02.047",
language = "English",
volume = "393",
pages = "656--661",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "4",

}

Nonmuscle myosin II localization is regulated by JNK during Drosophila larval wound healing. / Kwon, Young Chang; Baek, Seung Hee; Lee, Hyangkyu; Choe, Kwang-Min.

In: Biochemical and Biophysical Research Communications, Vol. 393, No. 4, 19.03.2010, p. 656-661.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nonmuscle myosin II localization is regulated by JNK during Drosophila larval wound healing

AU - Kwon, Young Chang

AU - Baek, Seung Hee

AU - Lee, Hyangkyu

AU - Choe, Kwang-Min

PY - 2010/3/19

Y1 - 2010/3/19

N2 - We investigated cell shape changes during wound closure in the Drosophila larval epidermis. During reepithelialization, epidermal cells permanently change shape from pentagonal or hexagonal to irregular forms. This process requires zipper, a gene encoding the Drosophila nonmuscle myosin II heavy chain. Following wounding, myosin II is localized at the wound margin and at the rear end of individual cells located within several rows from the wound hole. The c-Jun N-terminal kinase (JNK) pathway is essential for this myosin II localization. These results suggest that not only the wound leading edge but also the cells lying distal to the leading edge cells actively participate in epithelial cell sheet migration during wound hole closure.

AB - We investigated cell shape changes during wound closure in the Drosophila larval epidermis. During reepithelialization, epidermal cells permanently change shape from pentagonal or hexagonal to irregular forms. This process requires zipper, a gene encoding the Drosophila nonmuscle myosin II heavy chain. Following wounding, myosin II is localized at the wound margin and at the rear end of individual cells located within several rows from the wound hole. The c-Jun N-terminal kinase (JNK) pathway is essential for this myosin II localization. These results suggest that not only the wound leading edge but also the cells lying distal to the leading edge cells actively participate in epithelial cell sheet migration during wound hole closure.

UR - http://www.scopus.com/inward/record.url?scp=77949490113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949490113&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2010.02.047

DO - 10.1016/j.bbrc.2010.02.047

M3 - Article

VL - 393

SP - 656

EP - 661

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 4

ER -