Nonspecific intraventricular conduction delay is associated with future occurrence of atrial fibrillation in patients with structurally normal heart

Jae Sun Uhm, Youngchae Lee, Yun Ho Roh, Jinae Lee, Dongseon Kang, Moo Nyun Jin, In Soo Kim, Hee Tae Yu, Tae Hoon Kim, Jong Youn Kim, Boyoung Joung, Hui Nam Pak, Moon Hyoung Lee

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Abstract

Background: We aimed to elucidate the long-term prognosis of nonspecific intraventricular conduction delay (NIVCD) in patients with structurally normal heart. Methods: We included 107,838 patients (age, 52.1 ± 15.5 years; men, 46.8%) who underwent electrocardiography in outpatient clinics or medical checkup (unmatched cohort). NIVCD was defined as QRS duration ≥110 ms without meeting the criteria for bundle branch block. Patients with structurally normal heart and sinus rhythm were assigned to the NIVCD and normal QRS groups according to propensity score with matching variables of age, sex, hypertension, and diabetes (matched cohort 1), and additional PR interval (matched cohort 2). Baseline characteristics, electrocardiographic parameters, and clinical outcomes were compared in the unmatched cohort and the matched cohort. Results: In the unmatched cohort, the frequencies of male sex and preexisting atrial fibrillation were significantly higher in the NIVCD group than in the normal QRS group. In matched cohort 1 (n = 690), the NIVCD group exhibited significant slower sinus rate and longer PR interval than the normal QRS group. In matched cohort 2 (n = 598), the cumulative incidence of atrial fibrillation was significantly higher in the NIVCD group than in the normal QRS group during a follow-up period of 8.8 ± 2.9 years. NIVCD significantly increased the risk for AF (hazard ratio, 2.571; 95% confidence interval, 1.074–6.156; p = 0.034). Conclusions: It is suggested that NIVCD may be associated with future occurrence of atrial fibrillation in patients with structurally normal heart and sinus rhythm.

Original languageEnglish
JournalEuropean Journal of Internal Medicine
DOIs
Publication statusAccepted/In press - 2019 Jan 1

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All Science Journal Classification (ASJC) codes

  • Internal Medicine

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Uhm, J. S., Lee, Y., Roh, Y. H., Lee, J., Kang, D., Jin, M. N., Kim, I. S., Yu, H. T., Kim, T. H., Kim, J. Y., Joung, B., Pak, H. N., & Lee, M. H. (Accepted/In press). Nonspecific intraventricular conduction delay is associated with future occurrence of atrial fibrillation in patients with structurally normal heart. European Journal of Internal Medicine. https://doi.org/10.1016/j.ejim.2019.11.006