Abstract
Nonviral delivery is a promising strategy for cellular reprogramming to produce desired cell types from undifferentiated stem cells or terminally differentiated somatic cells. Nonviral delivery of genes (DNA, RNA), proteins, or peptides has the potential to reprogram somatic cells to pluripotent stem cells or other lineage cells, and to promote the differentiation of stem cells to specific lineages. Various delivery carriers (cationic polymers, lipids, scaffolds, transposons, cell-penetrating peptides), cargos (episomal plasmids, minicircle DNA, small interfering RNAs, microRNAs, proteins, peptides), and method (electroporation) have been reported. In this article, we review recent advances in nonviral delivery approaches for reprogramming cells to pluripotency or lineage specification.
| Original language | English |
|---|---|
| Pages (from-to) | 107-119 |
| Number of pages | 13 |
| Journal | Archives of pharmacal research |
| Volume | 37 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Molecular Medicine
- Organic Chemistry
- Medicine(all)
Cite this
}
Nonviral delivery for reprogramming to pluripotency and differentiation. / Park, Hyun Ji; Shin, Jisoo; Kim, Jin; Cho, Seung-Woo.
In: Archives of pharmacal research, Vol. 37, No. 1, 01.01.2014, p. 107-119.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Nonviral delivery for reprogramming to pluripotency and differentiation
AU - Park, Hyun Ji
AU - Shin, Jisoo
AU - Kim, Jin
AU - Cho, Seung-Woo
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Nonviral delivery is a promising strategy for cellular reprogramming to produce desired cell types from undifferentiated stem cells or terminally differentiated somatic cells. Nonviral delivery of genes (DNA, RNA), proteins, or peptides has the potential to reprogram somatic cells to pluripotent stem cells or other lineage cells, and to promote the differentiation of stem cells to specific lineages. Various delivery carriers (cationic polymers, lipids, scaffolds, transposons, cell-penetrating peptides), cargos (episomal plasmids, minicircle DNA, small interfering RNAs, microRNAs, proteins, peptides), and method (electroporation) have been reported. In this article, we review recent advances in nonviral delivery approaches for reprogramming cells to pluripotency or lineage specification.
AB - Nonviral delivery is a promising strategy for cellular reprogramming to produce desired cell types from undifferentiated stem cells or terminally differentiated somatic cells. Nonviral delivery of genes (DNA, RNA), proteins, or peptides has the potential to reprogram somatic cells to pluripotent stem cells or other lineage cells, and to promote the differentiation of stem cells to specific lineages. Various delivery carriers (cationic polymers, lipids, scaffolds, transposons, cell-penetrating peptides), cargos (episomal plasmids, minicircle DNA, small interfering RNAs, microRNAs, proteins, peptides), and method (electroporation) have been reported. In this article, we review recent advances in nonviral delivery approaches for reprogramming cells to pluripotency or lineage specification.
UR - http://www.scopus.com/inward/record.url?scp=84892940152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892940152&partnerID=8YFLogxK
U2 - 10.1007/s12272-013-0287-z
DO - 10.1007/s12272-013-0287-z
M3 - Review article
C2 - 24222505
AN - SCOPUS:84892940152
VL - 37
SP - 107
EP - 119
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
SN - 0253-6269
IS - 1
ER -