Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer

Seung Hwan Lee, Kyo Chul Koo, Dong Hoon Lee, Byung Ha Chung

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose To determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA). Methods We retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffusion-weighted, and dynamic precontrast and postcontrast image sequences were obtained for each patient. Of the 623 patients, 177(28.4%) exhibited non visible tumors on MRI of clinical stage T1c. The imaging results were compared with the pathological findings with respect to both stage and Gleason scores (GS). Results Of the 177 prostatectomy patients with non visible tumors on MRI, pathological findings resulted in the upgrading of 49(27.7%) patients to a sum of GS 7 or more. 101(57.1%) patients exhibited tumor volumes greater than 0.5cc. The biochemical recurrence rate was significantly higher in the pathological upgraded group compared with the nonupgraded group after a mean follow-up time of 29 months. In the multiple logistic analysis, non visible tumor on MRI was not a significant predictor of low-risk PCA. Conclusions Even though cancer foci were not visualized by postbiopsy MRI, the pathological tumor volumes and extent of GS upgrading were relatively high. Therefore, nonvisible tumors by multiparametric MRI do not appear to be predictive of low-risk PCA.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalProstate International
Volume3
Issue number4
DOIs
Publication statusPublished - 2015 Dec 1

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Prostatic Neoplasms
Magnetic Resonance Imaging
Neoplasm Grading
Neoplasms
Prostatectomy
Tumor Burden
Recurrence

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

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abstract = "Purpose To determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA). Methods We retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffusion-weighted, and dynamic precontrast and postcontrast image sequences were obtained for each patient. Of the 623 patients, 177(28.4{\%}) exhibited non visible tumors on MRI of clinical stage T1c. The imaging results were compared with the pathological findings with respect to both stage and Gleason scores (GS). Results Of the 177 prostatectomy patients with non visible tumors on MRI, pathological findings resulted in the upgrading of 49(27.7{\%}) patients to a sum of GS 7 or more. 101(57.1{\%}) patients exhibited tumor volumes greater than 0.5cc. The biochemical recurrence rate was significantly higher in the pathological upgraded group compared with the nonupgraded group after a mean follow-up time of 29 months. In the multiple logistic analysis, non visible tumor on MRI was not a significant predictor of low-risk PCA. Conclusions Even though cancer foci were not visualized by postbiopsy MRI, the pathological tumor volumes and extent of GS upgrading were relatively high. Therefore, nonvisible tumors by multiparametric MRI do not appear to be predictive of low-risk PCA.",
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Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer. / Lee, Seung Hwan; Koo, Kyo Chul; Lee, Dong Hoon; Chung, Byung Ha.

In: Prostate International, Vol. 3, No. 4, 01.12.2015, p. 127-131.

Research output: Contribution to journalArticle

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