"Normal" liver stiffness values differ between men and women: A prospective study for healthy living liver and kidney donors in a native Korean population

Beom Kyung Kim, Seungup Kim, Gi Hong Choi, WoongKyu Han, Mi Sung Park, Eun Hye Kim, Junyong Park, doyoung kim, Jin Sub Choi, Seung Choul Yang, Eun Hee Choi, Kijun Song, SangHoon Ahn, KwangHyub Han, Chae Yoon Chon

Research output: Contribution to journalArticle

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Abstract

Background and Aim: Liver stiffness (LS) measurement can distinguish individuals with potential liver disease (LD) from the general population. However, if LS is sex-sensitive, prevalence of LD may be incorrectly estimated when the same reference LS value is applied irrespective of sex. Here, we evaluated whether normal ranges of LS differ between healthy men and women. Methods: LS was measured in a cohort of healthy living liver and kidney donors, none of whom suffered from diabetes mellitus, hypertension, hepatitis B or C virus infection, heart or liver dysfunction, or metabolic syndrome. Patients with abnormal laboratory findings related to potential LD (platelet count<150×103/μL; aspartate aminotransferase>40IU/L; alanine aminotransferase [ALT]>40IU/L; albumin<3.3g/dL; total bilirubin>1.2mg/dL; gamma-glutamyl transpeptidase>54IU/L; alkaline phosphatase>115IU/L) were excluded. Results: Among 242 patients analyzed, the mean age was 34.1 for men (n=121) and 40.5years for women (n=121) (P<0.001). Men had a higher mean LS value than women (5.2±1.2 vs 4.8±1.1kPa/P<0.001). Multivariate-linear regression analysis identified sex as the only independent factor for LS values (β=0.361/P=0.021). Using the 5th-95th percentiles, we determined normal LS ranges of 3.7-7.0kPa in men and 3.3-6.8kPa in women. In subgroups with ALT<30IU/L (subgroup-1, n=216) and ALT<20IU/L (subgroup-2, n=163), men had significantly higher LS values than women (5.2±1.3 vs 4.7±1.1kPa/P=0.003 and 5.1±1.2 vs 4.7±1.1kPa/P=0.030, respectively), demonstrating an independent sex effect (β=0.483/P=0.003 and β=0.389/P=0.030, respectively). Conclusions: An independent sex effect on LS values was confirmed. Thus, sex-specific references should be used for effective screening based on LS measurements.

Original languageEnglish
Pages (from-to)781-788
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume27
Issue number4
DOIs
Publication statusPublished - 2012 Jan 1

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Tissue Donors
Prospective Studies
Kidney
Liver
Population
Liver Diseases
Alanine Transaminase
gamma-Glutamyltransferase
Virus Diseases
Hepatitis B virus
Hepacivirus
Alanine
Alkaline Phosphatase
Linear Models
Diabetes Mellitus
Reference Values
Blood Platelets
Regression Analysis
Hypertension

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{142ded1fd89f444488a8712ecc0ddeec,
title = "{"}Normal{"} liver stiffness values differ between men and women: A prospective study for healthy living liver and kidney donors in a native Korean population",
abstract = "Background and Aim: Liver stiffness (LS) measurement can distinguish individuals with potential liver disease (LD) from the general population. However, if LS is sex-sensitive, prevalence of LD may be incorrectly estimated when the same reference LS value is applied irrespective of sex. Here, we evaluated whether normal ranges of LS differ between healthy men and women. Methods: LS was measured in a cohort of healthy living liver and kidney donors, none of whom suffered from diabetes mellitus, hypertension, hepatitis B or C virus infection, heart or liver dysfunction, or metabolic syndrome. Patients with abnormal laboratory findings related to potential LD (platelet count<150×103/μL; aspartate aminotransferase>40IU/L; alanine aminotransferase [ALT]>40IU/L; albumin<3.3g/dL; total bilirubin>1.2mg/dL; gamma-glutamyl transpeptidase>54IU/L; alkaline phosphatase>115IU/L) were excluded. Results: Among 242 patients analyzed, the mean age was 34.1 for men (n=121) and 40.5years for women (n=121) (P<0.001). Men had a higher mean LS value than women (5.2±1.2 vs 4.8±1.1kPa/P<0.001). Multivariate-linear regression analysis identified sex as the only independent factor for LS values (β=0.361/P=0.021). Using the 5th-95th percentiles, we determined normal LS ranges of 3.7-7.0kPa in men and 3.3-6.8kPa in women. In subgroups with ALT<30IU/L (subgroup-1, n=216) and ALT<20IU/L (subgroup-2, n=163), men had significantly higher LS values than women (5.2±1.3 vs 4.7±1.1kPa/P=0.003 and 5.1±1.2 vs 4.7±1.1kPa/P=0.030, respectively), demonstrating an independent sex effect (β=0.483/P=0.003 and β=0.389/P=0.030, respectively). Conclusions: An independent sex effect on LS values was confirmed. Thus, sex-specific references should be used for effective screening based on LS measurements.",
author = "Kim, {Beom Kyung} and Seungup Kim and Choi, {Gi Hong} and WoongKyu Han and Park, {Mi Sung} and Kim, {Eun Hye} and Junyong Park and doyoung kim and Choi, {Jin Sub} and Yang, {Seung Choul} and Choi, {Eun Hee} and Kijun Song and SangHoon Ahn and KwangHyub Han and Chon, {Chae Yoon}",
year = "2012",
month = "1",
day = "1",
doi = "10.1111/j.1440-1746.2011.06962.x",
language = "English",
volume = "27",
pages = "781--788",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "4",

}

"Normal" liver stiffness values differ between men and women : A prospective study for healthy living liver and kidney donors in a native Korean population. / Kim, Beom Kyung; Kim, Seungup; Choi, Gi Hong; Han, WoongKyu; Park, Mi Sung; Kim, Eun Hye; Park, Junyong; kim, doyoung; Choi, Jin Sub; Yang, Seung Choul; Choi, Eun Hee; Song, Kijun; Ahn, SangHoon; Han, KwangHyub; Chon, Chae Yoon.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 27, No. 4, 01.01.2012, p. 781-788.

Research output: Contribution to journalArticle

TY - JOUR

T1 - "Normal" liver stiffness values differ between men and women

T2 - A prospective study for healthy living liver and kidney donors in a native Korean population

AU - Kim, Beom Kyung

AU - Kim, Seungup

AU - Choi, Gi Hong

AU - Han, WoongKyu

AU - Park, Mi Sung

AU - Kim, Eun Hye

AU - Park, Junyong

AU - kim, doyoung

AU - Choi, Jin Sub

AU - Yang, Seung Choul

AU - Choi, Eun Hee

AU - Song, Kijun

AU - Ahn, SangHoon

AU - Han, KwangHyub

AU - Chon, Chae Yoon

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background and Aim: Liver stiffness (LS) measurement can distinguish individuals with potential liver disease (LD) from the general population. However, if LS is sex-sensitive, prevalence of LD may be incorrectly estimated when the same reference LS value is applied irrespective of sex. Here, we evaluated whether normal ranges of LS differ between healthy men and women. Methods: LS was measured in a cohort of healthy living liver and kidney donors, none of whom suffered from diabetes mellitus, hypertension, hepatitis B or C virus infection, heart or liver dysfunction, or metabolic syndrome. Patients with abnormal laboratory findings related to potential LD (platelet count<150×103/μL; aspartate aminotransferase>40IU/L; alanine aminotransferase [ALT]>40IU/L; albumin<3.3g/dL; total bilirubin>1.2mg/dL; gamma-glutamyl transpeptidase>54IU/L; alkaline phosphatase>115IU/L) were excluded. Results: Among 242 patients analyzed, the mean age was 34.1 for men (n=121) and 40.5years for women (n=121) (P<0.001). Men had a higher mean LS value than women (5.2±1.2 vs 4.8±1.1kPa/P<0.001). Multivariate-linear regression analysis identified sex as the only independent factor for LS values (β=0.361/P=0.021). Using the 5th-95th percentiles, we determined normal LS ranges of 3.7-7.0kPa in men and 3.3-6.8kPa in women. In subgroups with ALT<30IU/L (subgroup-1, n=216) and ALT<20IU/L (subgroup-2, n=163), men had significantly higher LS values than women (5.2±1.3 vs 4.7±1.1kPa/P=0.003 and 5.1±1.2 vs 4.7±1.1kPa/P=0.030, respectively), demonstrating an independent sex effect (β=0.483/P=0.003 and β=0.389/P=0.030, respectively). Conclusions: An independent sex effect on LS values was confirmed. Thus, sex-specific references should be used for effective screening based on LS measurements.

AB - Background and Aim: Liver stiffness (LS) measurement can distinguish individuals with potential liver disease (LD) from the general population. However, if LS is sex-sensitive, prevalence of LD may be incorrectly estimated when the same reference LS value is applied irrespective of sex. Here, we evaluated whether normal ranges of LS differ between healthy men and women. Methods: LS was measured in a cohort of healthy living liver and kidney donors, none of whom suffered from diabetes mellitus, hypertension, hepatitis B or C virus infection, heart or liver dysfunction, or metabolic syndrome. Patients with abnormal laboratory findings related to potential LD (platelet count<150×103/μL; aspartate aminotransferase>40IU/L; alanine aminotransferase [ALT]>40IU/L; albumin<3.3g/dL; total bilirubin>1.2mg/dL; gamma-glutamyl transpeptidase>54IU/L; alkaline phosphatase>115IU/L) were excluded. Results: Among 242 patients analyzed, the mean age was 34.1 for men (n=121) and 40.5years for women (n=121) (P<0.001). Men had a higher mean LS value than women (5.2±1.2 vs 4.8±1.1kPa/P<0.001). Multivariate-linear regression analysis identified sex as the only independent factor for LS values (β=0.361/P=0.021). Using the 5th-95th percentiles, we determined normal LS ranges of 3.7-7.0kPa in men and 3.3-6.8kPa in women. In subgroups with ALT<30IU/L (subgroup-1, n=216) and ALT<20IU/L (subgroup-2, n=163), men had significantly higher LS values than women (5.2±1.3 vs 4.7±1.1kPa/P=0.003 and 5.1±1.2 vs 4.7±1.1kPa/P=0.030, respectively), demonstrating an independent sex effect (β=0.483/P=0.003 and β=0.389/P=0.030, respectively). Conclusions: An independent sex effect on LS values was confirmed. Thus, sex-specific references should be used for effective screening based on LS measurements.

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U2 - 10.1111/j.1440-1746.2011.06962.x

DO - 10.1111/j.1440-1746.2011.06962.x

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JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

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