Normative values and correlates of mean common carotid intima-media thickness in the Korean rural middle-aged population

The atherosclerosis RIsk of rural areas iN Korea general population (ARIRANG) study

Youngjin Youn, Nam Seok Lee, Jang Young Kim, Junwon Lee, Joong Kyung Sung, Sung Gyun Ahn, Byung Su You, Seunghwan Lee, Junghan Yoon, Kyung Hoon Choe, Sangbaek Koh, Jong Ku Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Carotid intima-media thickness (CIMT) is considered as a surrogate marker for cardiovascular disease (CVD). We determined the normative value of CIMT and correlates of CVD risk factors and Framingham risk score (FRS) in Korean rural middle-aged population. We measured CIMT with a B-mode ultrasonography in 1,759 subjects, aged 40 to 70 yr, in a population-based cohort in Korea. A healthy reference sample (n = 433) without CVD, normal weight and normal metabolic parameters was selected to establish normative CIMT values. Correlates between CIMT and conventional CVD risk factors were assessed in the entire population. Mean values of CIMT (in mm) for healthy reference sample aged 40-49, 50-59, and 60-70 yr were 0.55, 0.59, and 0.66 for men and 0.48, 0.55, and 0.63 for women, respectively. In multivariate regression analysis, CIMT was correlated with older age, higher BMI, male gender, higher LDL-cholesterol level and history of diabetes mellitus. The mean CIMT was also correlated with FRS in both gender (r 2 = 0.043, P < 0.01 for men; r 2 = 0.142, P < 0.01 for women). We identified normative value of CIMT for the healthy Korean rural middle-aged population. The CIMT is associated with age, obesity, gender, LDL-cholesterol, diabetes mellitus and FRS.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalJournal of Korean medical science
Volume26
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

Fingerprint

Carotid Intima-Media Thickness
Korea
Atherosclerosis
Population
Cardiovascular Diseases
LDL Cholesterol
Diabetes Mellitus
Hypercholesterolemia
Ultrasonography
Multivariate Analysis
Obesity
Biomarkers
Regression Analysis
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{f96ba739022c41cfb020c4ddad780bdd,
title = "Normative values and correlates of mean common carotid intima-media thickness in the Korean rural middle-aged population: The atherosclerosis RIsk of rural areas iN Korea general population (ARIRANG) study",
abstract = "Carotid intima-media thickness (CIMT) is considered as a surrogate marker for cardiovascular disease (CVD). We determined the normative value of CIMT and correlates of CVD risk factors and Framingham risk score (FRS) in Korean rural middle-aged population. We measured CIMT with a B-mode ultrasonography in 1,759 subjects, aged 40 to 70 yr, in a population-based cohort in Korea. A healthy reference sample (n = 433) without CVD, normal weight and normal metabolic parameters was selected to establish normative CIMT values. Correlates between CIMT and conventional CVD risk factors were assessed in the entire population. Mean values of CIMT (in mm) for healthy reference sample aged 40-49, 50-59, and 60-70 yr were 0.55, 0.59, and 0.66 for men and 0.48, 0.55, and 0.63 for women, respectively. In multivariate regression analysis, CIMT was correlated with older age, higher BMI, male gender, higher LDL-cholesterol level and history of diabetes mellitus. The mean CIMT was also correlated with FRS in both gender (r 2 = 0.043, P < 0.01 for men; r 2 = 0.142, P < 0.01 for women). We identified normative value of CIMT for the healthy Korean rural middle-aged population. The CIMT is associated with age, obesity, gender, LDL-cholesterol, diabetes mellitus and FRS.",
author = "Youngjin Youn and Lee, {Nam Seok} and Kim, {Jang Young} and Junwon Lee and Sung, {Joong Kyung} and Ahn, {Sung Gyun} and You, {Byung Su} and Seunghwan Lee and Junghan Yoon and Choe, {Kyung Hoon} and Sangbaek Koh and Park, {Jong Ku}",
year = "2011",
month = "3",
day = "1",
doi = "10.3346/jkms.2011.26.3.365",
language = "English",
volume = "26",
pages = "365--371",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "3",

}

Normative values and correlates of mean common carotid intima-media thickness in the Korean rural middle-aged population : The atherosclerosis RIsk of rural areas iN Korea general population (ARIRANG) study. / Youn, Youngjin; Lee, Nam Seok; Kim, Jang Young; Lee, Junwon; Sung, Joong Kyung; Ahn, Sung Gyun; You, Byung Su; Lee, Seunghwan; Yoon, Junghan; Choe, Kyung Hoon; Koh, Sangbaek; Park, Jong Ku.

In: Journal of Korean medical science, Vol. 26, No. 3, 01.03.2011, p. 365-371.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Normative values and correlates of mean common carotid intima-media thickness in the Korean rural middle-aged population

T2 - The atherosclerosis RIsk of rural areas iN Korea general population (ARIRANG) study

AU - Youn, Youngjin

AU - Lee, Nam Seok

AU - Kim, Jang Young

AU - Lee, Junwon

AU - Sung, Joong Kyung

AU - Ahn, Sung Gyun

AU - You, Byung Su

AU - Lee, Seunghwan

AU - Yoon, Junghan

AU - Choe, Kyung Hoon

AU - Koh, Sangbaek

AU - Park, Jong Ku

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Carotid intima-media thickness (CIMT) is considered as a surrogate marker for cardiovascular disease (CVD). We determined the normative value of CIMT and correlates of CVD risk factors and Framingham risk score (FRS) in Korean rural middle-aged population. We measured CIMT with a B-mode ultrasonography in 1,759 subjects, aged 40 to 70 yr, in a population-based cohort in Korea. A healthy reference sample (n = 433) without CVD, normal weight and normal metabolic parameters was selected to establish normative CIMT values. Correlates between CIMT and conventional CVD risk factors were assessed in the entire population. Mean values of CIMT (in mm) for healthy reference sample aged 40-49, 50-59, and 60-70 yr were 0.55, 0.59, and 0.66 for men and 0.48, 0.55, and 0.63 for women, respectively. In multivariate regression analysis, CIMT was correlated with older age, higher BMI, male gender, higher LDL-cholesterol level and history of diabetes mellitus. The mean CIMT was also correlated with FRS in both gender (r 2 = 0.043, P < 0.01 for men; r 2 = 0.142, P < 0.01 for women). We identified normative value of CIMT for the healthy Korean rural middle-aged population. The CIMT is associated with age, obesity, gender, LDL-cholesterol, diabetes mellitus and FRS.

AB - Carotid intima-media thickness (CIMT) is considered as a surrogate marker for cardiovascular disease (CVD). We determined the normative value of CIMT and correlates of CVD risk factors and Framingham risk score (FRS) in Korean rural middle-aged population. We measured CIMT with a B-mode ultrasonography in 1,759 subjects, aged 40 to 70 yr, in a population-based cohort in Korea. A healthy reference sample (n = 433) without CVD, normal weight and normal metabolic parameters was selected to establish normative CIMT values. Correlates between CIMT and conventional CVD risk factors were assessed in the entire population. Mean values of CIMT (in mm) for healthy reference sample aged 40-49, 50-59, and 60-70 yr were 0.55, 0.59, and 0.66 for men and 0.48, 0.55, and 0.63 for women, respectively. In multivariate regression analysis, CIMT was correlated with older age, higher BMI, male gender, higher LDL-cholesterol level and history of diabetes mellitus. The mean CIMT was also correlated with FRS in both gender (r 2 = 0.043, P < 0.01 for men; r 2 = 0.142, P < 0.01 for women). We identified normative value of CIMT for the healthy Korean rural middle-aged population. The CIMT is associated with age, obesity, gender, LDL-cholesterol, diabetes mellitus and FRS.

UR - http://www.scopus.com/inward/record.url?scp=79953743930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953743930&partnerID=8YFLogxK

U2 - 10.3346/jkms.2011.26.3.365

DO - 10.3346/jkms.2011.26.3.365

M3 - Article

VL - 26

SP - 365

EP - 371

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 3

ER -