Normative values of carotid artery intima-media thickness in healthy Korean adults and estimation of macrovascular diseases relative risk using this data in type 2 diabetes patients

Chul Sik Kim, Hyeong Jin Kim, Young Jun Won, Dae Jung Kim, Eun Seok Kang, Chul Woo Ahn, Bong Soo Cha, Sungkil Lim, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The objectives of this study were to determine normative values of carotid intima-media thickness (IMT) in healthy Korean subjects and to use these values to estimate the relative risk of macrovascular diseases in patients with type 2 diabetes mellitus (T2DM). High-resolution B-mode ultrasonography was performed in 1229 healthy subjects and 830 T2DM patients. Height, weight, blood pressure, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, and fasting insulin level were measured. Subjects were classified as healthy subjects; T2DM patients without ischemic heart disease (IHD), stroke, and peripheral arterial occlusive diseases (PAOD); T2DM patients with IHD, stroke, or PAOD. IMT was significantly increased as age increased. Patients with T2DM had higher IMTs compared to healthy subjects. Independent risk factors of IMT were age, systolic blood pressure, BMI for healthy subjects, and age, duration of diabetes, LDL-cholesterol for T2DM subjects. According to presence of increased IMT, the relative risks of IHD, stroke, and PAOD in diabetic subjects, were 2.34 (CI; 1.32-4.14), 2.95 (CI; 1.46-5.54), and 3.64 (CI; 1.66-7.40), respectively. This study suggests normative values that can be used as an index for carotid artery IMT of healthy Korean subjects, and that IMT data reflects the risk of macrovascular diseases in T2DM.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume72
Issue number2
DOIs
Publication statusPublished - 2006 May 1

Fingerprint

Carotid Intima-Media Thickness
Carotid Arteries
Type 2 Diabetes Mellitus
Healthy Volunteers
Arterial Occlusive Diseases
Peripheral Arterial Disease
Myocardial Ischemia
Stroke
Blood Pressure
LDL Cholesterol
Fasting
LDL Lipoproteins
HDL Cholesterol
Ultrasonography
Triglycerides
Cholesterol
Insulin
Weights and Measures
Glucose

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kim, Chul Sik ; Kim, Hyeong Jin ; Won, Young Jun ; Kim, Dae Jung ; Kang, Eun Seok ; Ahn, Chul Woo ; Cha, Bong Soo ; Lim, Sungkil ; Kim, Kyung Rae ; Lee, Hyun Chul ; Huh, Kap Bum. / Normative values of carotid artery intima-media thickness in healthy Korean adults and estimation of macrovascular diseases relative risk using this data in type 2 diabetes patients. In: Diabetes Research and Clinical Practice. 2006 ; Vol. 72, No. 2. pp. 183-189.
@article{6b635d4ebf16472c8173a102f8f22cee,
title = "Normative values of carotid artery intima-media thickness in healthy Korean adults and estimation of macrovascular diseases relative risk using this data in type 2 diabetes patients",
abstract = "The objectives of this study were to determine normative values of carotid intima-media thickness (IMT) in healthy Korean subjects and to use these values to estimate the relative risk of macrovascular diseases in patients with type 2 diabetes mellitus (T2DM). High-resolution B-mode ultrasonography was performed in 1229 healthy subjects and 830 T2DM patients. Height, weight, blood pressure, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, and fasting insulin level were measured. Subjects were classified as healthy subjects; T2DM patients without ischemic heart disease (IHD), stroke, and peripheral arterial occlusive diseases (PAOD); T2DM patients with IHD, stroke, or PAOD. IMT was significantly increased as age increased. Patients with T2DM had higher IMTs compared to healthy subjects. Independent risk factors of IMT were age, systolic blood pressure, BMI for healthy subjects, and age, duration of diabetes, LDL-cholesterol for T2DM subjects. According to presence of increased IMT, the relative risks of IHD, stroke, and PAOD in diabetic subjects, were 2.34 (CI; 1.32-4.14), 2.95 (CI; 1.46-5.54), and 3.64 (CI; 1.66-7.40), respectively. This study suggests normative values that can be used as an index for carotid artery IMT of healthy Korean subjects, and that IMT data reflects the risk of macrovascular diseases in T2DM.",
author = "Kim, {Chul Sik} and Kim, {Hyeong Jin} and Won, {Young Jun} and Kim, {Dae Jung} and Kang, {Eun Seok} and Ahn, {Chul Woo} and Cha, {Bong Soo} and Sungkil Lim and Kim, {Kyung Rae} and Lee, {Hyun Chul} and Huh, {Kap Bum}",
year = "2006",
month = "5",
day = "1",
doi = "10.1016/j.diabres.2005.10.011",
language = "English",
volume = "72",
pages = "183--189",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Normative values of carotid artery intima-media thickness in healthy Korean adults and estimation of macrovascular diseases relative risk using this data in type 2 diabetes patients. / Kim, Chul Sik; Kim, Hyeong Jin; Won, Young Jun; Kim, Dae Jung; Kang, Eun Seok; Ahn, Chul Woo; Cha, Bong Soo; Lim, Sungkil; Kim, Kyung Rae; Lee, Hyun Chul; Huh, Kap Bum.

In: Diabetes Research and Clinical Practice, Vol. 72, No. 2, 01.05.2006, p. 183-189.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Normative values of carotid artery intima-media thickness in healthy Korean adults and estimation of macrovascular diseases relative risk using this data in type 2 diabetes patients

AU - Kim, Chul Sik

AU - Kim, Hyeong Jin

AU - Won, Young Jun

AU - Kim, Dae Jung

AU - Kang, Eun Seok

AU - Ahn, Chul Woo

AU - Cha, Bong Soo

AU - Lim, Sungkil

AU - Kim, Kyung Rae

AU - Lee, Hyun Chul

AU - Huh, Kap Bum

PY - 2006/5/1

Y1 - 2006/5/1

N2 - The objectives of this study were to determine normative values of carotid intima-media thickness (IMT) in healthy Korean subjects and to use these values to estimate the relative risk of macrovascular diseases in patients with type 2 diabetes mellitus (T2DM). High-resolution B-mode ultrasonography was performed in 1229 healthy subjects and 830 T2DM patients. Height, weight, blood pressure, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, and fasting insulin level were measured. Subjects were classified as healthy subjects; T2DM patients without ischemic heart disease (IHD), stroke, and peripheral arterial occlusive diseases (PAOD); T2DM patients with IHD, stroke, or PAOD. IMT was significantly increased as age increased. Patients with T2DM had higher IMTs compared to healthy subjects. Independent risk factors of IMT were age, systolic blood pressure, BMI for healthy subjects, and age, duration of diabetes, LDL-cholesterol for T2DM subjects. According to presence of increased IMT, the relative risks of IHD, stroke, and PAOD in diabetic subjects, were 2.34 (CI; 1.32-4.14), 2.95 (CI; 1.46-5.54), and 3.64 (CI; 1.66-7.40), respectively. This study suggests normative values that can be used as an index for carotid artery IMT of healthy Korean subjects, and that IMT data reflects the risk of macrovascular diseases in T2DM.

AB - The objectives of this study were to determine normative values of carotid intima-media thickness (IMT) in healthy Korean subjects and to use these values to estimate the relative risk of macrovascular diseases in patients with type 2 diabetes mellitus (T2DM). High-resolution B-mode ultrasonography was performed in 1229 healthy subjects and 830 T2DM patients. Height, weight, blood pressure, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, and fasting insulin level were measured. Subjects were classified as healthy subjects; T2DM patients without ischemic heart disease (IHD), stroke, and peripheral arterial occlusive diseases (PAOD); T2DM patients with IHD, stroke, or PAOD. IMT was significantly increased as age increased. Patients with T2DM had higher IMTs compared to healthy subjects. Independent risk factors of IMT were age, systolic blood pressure, BMI for healthy subjects, and age, duration of diabetes, LDL-cholesterol for T2DM subjects. According to presence of increased IMT, the relative risks of IHD, stroke, and PAOD in diabetic subjects, were 2.34 (CI; 1.32-4.14), 2.95 (CI; 1.46-5.54), and 3.64 (CI; 1.66-7.40), respectively. This study suggests normative values that can be used as an index for carotid artery IMT of healthy Korean subjects, and that IMT data reflects the risk of macrovascular diseases in T2DM.

UR - http://www.scopus.com/inward/record.url?scp=33646151624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646151624&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2005.10.011

DO - 10.1016/j.diabres.2005.10.011

M3 - Article

VL - 72

SP - 183

EP - 189

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 2

ER -