Nosocomial outbreak caused by NDM-5 and OXA-181 carbapenemase co-producing Escherichia coli

Kwangjin Ahn, Gyu Yel Hwang, Young Keun Kim, Hyo Youl Kim, Hye Ran Jeong, Jun Sung Hong, Young Uh

Research output: Contribution to journalArticle

Abstract

Carbapenemase-producing Enterobacteriaceae (CPE) is an important and increasing threat to global health. From July to September 2017, 20 inpatients at a tertiary care hospital in Korea were either colonized or infected with carbapenem-resistant Escherichia coli strains. All of E. coli isolates co-produced blaNDM-5 and blaOXA-181 carbapenemase genes and shared ≥88% clonal relatedness on the basis of a cladistic calculation of the distribution of pulsed-field gel electrophoresis patterns. Rapid detection of CPE is one of the most important factors to prevent CPE dissemination because it takes long time for CPE to become negative.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalInfection and Chemotherapy
Volume51
Issue number2
DOIs
Publication statusPublished - 2019 Jan 1

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Disease Outbreaks
Enterobacteriaceae
Escherichia coli
Carbapenems
Pulsed Field Gel Electrophoresis
Tertiary Healthcare
Korea
Tertiary Care Centers
Inpatients
carbapenemase
Asp(5)-oxytocin
Genes

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Ahn, Kwangjin ; Hwang, Gyu Yel ; Kim, Young Keun ; Kim, Hyo Youl ; Jeong, Hye Ran ; Hong, Jun Sung ; Uh, Young. / Nosocomial outbreak caused by NDM-5 and OXA-181 carbapenemase co-producing Escherichia coli. In: Infection and Chemotherapy. 2019 ; Vol. 51, No. 2. pp. 177-182.
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Nosocomial outbreak caused by NDM-5 and OXA-181 carbapenemase co-producing Escherichia coli. / Ahn, Kwangjin; Hwang, Gyu Yel; Kim, Young Keun; Kim, Hyo Youl; Jeong, Hye Ran; Hong, Jun Sung; Uh, Young.

In: Infection and Chemotherapy, Vol. 51, No. 2, 01.01.2019, p. 177-182.

Research output: Contribution to journalArticle

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AB - Carbapenemase-producing Enterobacteriaceae (CPE) is an important and increasing threat to global health. From July to September 2017, 20 inpatients at a tertiary care hospital in Korea were either colonized or infected with carbapenem-resistant Escherichia coli strains. All of E. coli isolates co-produced blaNDM-5 and blaOXA-181 carbapenemase genes and shared ≥88% clonal relatedness on the basis of a cladistic calculation of the distribution of pulsed-field gel electrophoresis patterns. Rapid detection of CPE is one of the most important factors to prevent CPE dissemination because it takes long time for CPE to become negative.

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