NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal

Sun Och Yoon, Eun Kyung Kim, Mira Lee, Woon Yong Jung, Hyunjoo Lee, Youngran Kang, You Jin Jang, Soon Won Hong, Seung Ho Choi, Woo Ick Yang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Occult residual disease in remnant tissues could be the cause of tumor relapse. To identify signal molecules and target cells that may be indicative of occult residual disease within a remnant microenvironment, proximal resection margin tissues of gastric cancers were used, as these correspond to the nearest remnant tissues after gastrectomy. Increased miR-146b-5p in the remnant microenvironment was determined to be a strong risk factor for tumor relapse and poor survival rate. NOVA1, a target gene of miR-146b-5p, was decreased in remnant tissues of patients with a poor prognosis. NOVA1 was enriched in stromal spindle cells such as fibroblasts within normal tissues. In non-neoplastic inflammation, such as gastritis, NOVA1 was highly enriched in T lymphocytes and stromal spindle cells, while expression of this protein was frequently decreased in those types of cells within gastric cancer tissues. Particularly, decreased NOVA1 in T cells within the gastric cancer tissues was correlated with decreased FOXP3-positive regulatory T cells and was associated with poor patient prognosis. In vitro analysis showed that the NOVA1 gene was inhibited by miR-146b-5p. In immune cells as well as stromal spindle cells, decreased NOVA1, possibly inhibited by miR- 146b-5p, is a candidate biomarker predicting poor prognosis of gastric cancer patients and is also a biomarker of occult residual disease in remnant tissues after gastric cancer removal.

Original languageEnglish
Pages (from-to)2475-2495
Number of pages21
JournalOncotarget
Volume7
Issue number3
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Stomach Neoplasms
Stromal Cells
Biomarkers
T-Lymphocytes
Recurrence
Gastritis
Regulatory T-Lymphocytes
Gastrectomy
Genes
Neoplasms
Survival Rate
Fibroblasts
Inflammation
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Yoon, Sun Och ; Kim, Eun Kyung ; Lee, Mira ; Jung, Woon Yong ; Lee, Hyunjoo ; Kang, Youngran ; Jang, You Jin ; Hong, Soon Won ; Choi, Seung Ho ; Yang, Woo Ick. / NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal. In: Oncotarget. 2016 ; Vol. 7, No. 3. pp. 2475-2495.
@article{035f9f1208a94a59a1e7f5e7aad5a8cc,
title = "NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal",
abstract = "Occult residual disease in remnant tissues could be the cause of tumor relapse. To identify signal molecules and target cells that may be indicative of occult residual disease within a remnant microenvironment, proximal resection margin tissues of gastric cancers were used, as these correspond to the nearest remnant tissues after gastrectomy. Increased miR-146b-5p in the remnant microenvironment was determined to be a strong risk factor for tumor relapse and poor survival rate. NOVA1, a target gene of miR-146b-5p, was decreased in remnant tissues of patients with a poor prognosis. NOVA1 was enriched in stromal spindle cells such as fibroblasts within normal tissues. In non-neoplastic inflammation, such as gastritis, NOVA1 was highly enriched in T lymphocytes and stromal spindle cells, while expression of this protein was frequently decreased in those types of cells within gastric cancer tissues. Particularly, decreased NOVA1 in T cells within the gastric cancer tissues was correlated with decreased FOXP3-positive regulatory T cells and was associated with poor patient prognosis. In vitro analysis showed that the NOVA1 gene was inhibited by miR-146b-5p. In immune cells as well as stromal spindle cells, decreased NOVA1, possibly inhibited by miR- 146b-5p, is a candidate biomarker predicting poor prognosis of gastric cancer patients and is also a biomarker of occult residual disease in remnant tissues after gastric cancer removal.",
author = "Yoon, {Sun Och} and Kim, {Eun Kyung} and Mira Lee and Jung, {Woon Yong} and Hyunjoo Lee and Youngran Kang and Jang, {You Jin} and Hong, {Soon Won} and Choi, {Seung Ho} and Yang, {Woo Ick}",
year = "2016",
month = "1",
day = "1",
doi = "10.18632/oncotarget.6542",
language = "English",
volume = "7",
pages = "2475--2495",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",
number = "3",

}

NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal. / Yoon, Sun Och; Kim, Eun Kyung; Lee, Mira; Jung, Woon Yong; Lee, Hyunjoo; Kang, Youngran; Jang, You Jin; Hong, Soon Won; Choi, Seung Ho; Yang, Woo Ick.

In: Oncotarget, Vol. 7, No. 3, 01.01.2016, p. 2475-2495.

Research output: Contribution to journalArticle

TY - JOUR

T1 - NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal

AU - Yoon, Sun Och

AU - Kim, Eun Kyung

AU - Lee, Mira

AU - Jung, Woon Yong

AU - Lee, Hyunjoo

AU - Kang, Youngran

AU - Jang, You Jin

AU - Hong, Soon Won

AU - Choi, Seung Ho

AU - Yang, Woo Ick

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Occult residual disease in remnant tissues could be the cause of tumor relapse. To identify signal molecules and target cells that may be indicative of occult residual disease within a remnant microenvironment, proximal resection margin tissues of gastric cancers were used, as these correspond to the nearest remnant tissues after gastrectomy. Increased miR-146b-5p in the remnant microenvironment was determined to be a strong risk factor for tumor relapse and poor survival rate. NOVA1, a target gene of miR-146b-5p, was decreased in remnant tissues of patients with a poor prognosis. NOVA1 was enriched in stromal spindle cells such as fibroblasts within normal tissues. In non-neoplastic inflammation, such as gastritis, NOVA1 was highly enriched in T lymphocytes and stromal spindle cells, while expression of this protein was frequently decreased in those types of cells within gastric cancer tissues. Particularly, decreased NOVA1 in T cells within the gastric cancer tissues was correlated with decreased FOXP3-positive regulatory T cells and was associated with poor patient prognosis. In vitro analysis showed that the NOVA1 gene was inhibited by miR-146b-5p. In immune cells as well as stromal spindle cells, decreased NOVA1, possibly inhibited by miR- 146b-5p, is a candidate biomarker predicting poor prognosis of gastric cancer patients and is also a biomarker of occult residual disease in remnant tissues after gastric cancer removal.

AB - Occult residual disease in remnant tissues could be the cause of tumor relapse. To identify signal molecules and target cells that may be indicative of occult residual disease within a remnant microenvironment, proximal resection margin tissues of gastric cancers were used, as these correspond to the nearest remnant tissues after gastrectomy. Increased miR-146b-5p in the remnant microenvironment was determined to be a strong risk factor for tumor relapse and poor survival rate. NOVA1, a target gene of miR-146b-5p, was decreased in remnant tissues of patients with a poor prognosis. NOVA1 was enriched in stromal spindle cells such as fibroblasts within normal tissues. In non-neoplastic inflammation, such as gastritis, NOVA1 was highly enriched in T lymphocytes and stromal spindle cells, while expression of this protein was frequently decreased in those types of cells within gastric cancer tissues. Particularly, decreased NOVA1 in T cells within the gastric cancer tissues was correlated with decreased FOXP3-positive regulatory T cells and was associated with poor patient prognosis. In vitro analysis showed that the NOVA1 gene was inhibited by miR-146b-5p. In immune cells as well as stromal spindle cells, decreased NOVA1, possibly inhibited by miR- 146b-5p, is a candidate biomarker predicting poor prognosis of gastric cancer patients and is also a biomarker of occult residual disease in remnant tissues after gastric cancer removal.

UR - http://www.scopus.com/inward/record.url?scp=84962208569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962208569&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.6542

DO - 10.18632/oncotarget.6542

M3 - Article

C2 - 26673617

AN - SCOPUS:84962208569

VL - 7

SP - 2475

EP - 2495

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 3

ER -