Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: A proof-ofconcept study

Jung Chul Park, Jong Bin Lee, Guy Daculsi, Sang Yeop Oh, Kyoo Sung Cho, Gun Il Im, Byung Soo Kim, Chang Sung Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: The osseointegration around titanium mini-implants installed in macroporous biphasic calcium phosphate (MBCP) blocks was evaluated after incubation with recombinant human bone morphogenetic protein-2 (rhBMP-2) in an ectopic subcutaneous rat model. Methods: Mini-implants (φ.8×12 mm) were installed in MBCP blocks (bMBCPs, 4×5×15 mm) loaded with rhBMP-2 at 0.1 mg/mL, and then implanted for 8 weeks into subcutaneous pockets of male Sprague-Dawley rats (n=10). A histomorphometric analysis was performed, and the bone-to-implant contact (BIC) and bone density were evaluated. Results: Significant osteoinductive activity was induced in the rhBMP-2/bMBCP group. The percentage of BIC was 41.23 t 4.13% (mean ± standard deviation), while bone density was 33.47 ±5.73%. In contrast, no bone formation was observed in the bMBCP only group. Conclusions: This model represents a more standardized tool for analyzing osseointegration and bone healing along the implant surface and in bMBCPs that excludes various healing factors derived from selected animals and defect models.

Original languageEnglish
Pages (from-to)136-143
Number of pages8
JournalJournal of Periodontal and Implant Science
Volume42
Issue number4
DOIs
Publication statusPublished - 2012 Aug

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Periodontics

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