Abstract
Manipulation of magnetically labeled cells in a microfluidic channel is becoming a very important technique in the field of biomedical science. A microfabricated electromagnet produces a large magnetic field gradient in a cell sorting system. The microfabricated electromagnet generates Joule heating so it causes unnecessary heat-up in the device, which has been problematic for the development of a Lab-On-a-Chip (LOC). In this paper, we present a new application of Joule heating to supply thermal energy to an active area of a microfluidic device to increase the internal temperature of the device from ambient to a biocompatible temperature, e.g. 37 °C. The temperature is maintained in conjunction with coolant. We analyzed the temperature distribution of the device numerically and the results were in good agreement with the experimental data. Our approach will facilitate development of cell chips such as a micro-mammalian cell culture or electromagnetic micro-cell sorter. Crown
| Original language | English |
|---|---|
| Pages (from-to) | 64-70 |
| Number of pages | 7 |
| Journal | Sensors and Actuators, A: Physical |
| Volume | 151 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 Apr 8 |
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All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Instrumentation
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering
Cite this
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Novel application of Joule heating to maintain biocompatible temperatures in a fully integrated electromagnetic cell sorting system. / Song, Suk Heung; Kwak, Bong Seop; Park, Jae Sung; Kim, Woochul; Jung, Hyo IL.
In: Sensors and Actuators, A: Physical, Vol. 151, No. 1, 08.04.2009, p. 64-70.Research output: Contribution to journal › Article
TY - JOUR
T1 - Novel application of Joule heating to maintain biocompatible temperatures in a fully integrated electromagnetic cell sorting system
AU - Song, Suk Heung
AU - Kwak, Bong Seop
AU - Park, Jae Sung
AU - Kim, Woochul
AU - Jung, Hyo IL
PY - 2009/4/8
Y1 - 2009/4/8
N2 - Manipulation of magnetically labeled cells in a microfluidic channel is becoming a very important technique in the field of biomedical science. A microfabricated electromagnet produces a large magnetic field gradient in a cell sorting system. The microfabricated electromagnet generates Joule heating so it causes unnecessary heat-up in the device, which has been problematic for the development of a Lab-On-a-Chip (LOC). In this paper, we present a new application of Joule heating to supply thermal energy to an active area of a microfluidic device to increase the internal temperature of the device from ambient to a biocompatible temperature, e.g. 37 °C. The temperature is maintained in conjunction with coolant. We analyzed the temperature distribution of the device numerically and the results were in good agreement with the experimental data. Our approach will facilitate development of cell chips such as a micro-mammalian cell culture or electromagnetic micro-cell sorter. Crown
AB - Manipulation of magnetically labeled cells in a microfluidic channel is becoming a very important technique in the field of biomedical science. A microfabricated electromagnet produces a large magnetic field gradient in a cell sorting system. The microfabricated electromagnet generates Joule heating so it causes unnecessary heat-up in the device, which has been problematic for the development of a Lab-On-a-Chip (LOC). In this paper, we present a new application of Joule heating to supply thermal energy to an active area of a microfluidic device to increase the internal temperature of the device from ambient to a biocompatible temperature, e.g. 37 °C. The temperature is maintained in conjunction with coolant. We analyzed the temperature distribution of the device numerically and the results were in good agreement with the experimental data. Our approach will facilitate development of cell chips such as a micro-mammalian cell culture or electromagnetic micro-cell sorter. Crown
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U2 - 10.1016/j.sna.2009.02.006
DO - 10.1016/j.sna.2009.02.006
M3 - Article
AN - SCOPUS:63049118426
VL - 151
SP - 64
EP - 70
JO - Sensors and Actuators, A: Physical
JF - Sensors and Actuators, A: Physical
SN - 0924-4247
IS - 1
ER -