Novel application of Joule heating to maintain biocompatible temperatures in a fully integrated electromagnetic cell sorting system

Suk Heung Song, Bong Seop Kwak, Jae Sung Park, Woochul Kim, Hyo IL Jung

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Manipulation of magnetically labeled cells in a microfluidic channel is becoming a very important technique in the field of biomedical science. A microfabricated electromagnet produces a large magnetic field gradient in a cell sorting system. The microfabricated electromagnet generates Joule heating so it causes unnecessary heat-up in the device, which has been problematic for the development of a Lab-On-a-Chip (LOC). In this paper, we present a new application of Joule heating to supply thermal energy to an active area of a microfluidic device to increase the internal temperature of the device from ambient to a biocompatible temperature, e.g. 37 °C. The temperature is maintained in conjunction with coolant. We analyzed the temperature distribution of the device numerically and the results were in good agreement with the experimental data. Our approach will facilitate development of cell chips such as a micro-mammalian cell culture or electromagnetic micro-cell sorter. Crown

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalSensors and Actuators, A: Physical
Volume151
Issue number1
DOIs
Publication statusPublished - 2009 Apr 8

Fingerprint

Joule heating
classifying
Sorting
Electromagnets
electromagnets
Cells
electromagnetism
Microfluidics
cells
chips
Lab-on-a-chip
microfluidic devices
coolants
Thermal energy
Cell culture
thermal energy
Coolants
Temperature
temperature
manipulators

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering

Cite this

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Novel application of Joule heating to maintain biocompatible temperatures in a fully integrated electromagnetic cell sorting system. / Song, Suk Heung; Kwak, Bong Seop; Park, Jae Sung; Kim, Woochul; Jung, Hyo IL.

In: Sensors and Actuators, A: Physical, Vol. 151, No. 1, 08.04.2009, p. 64-70.

Research output: Contribution to journalArticle

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