Novel application of Joule heating to maintain biocompatible temperatures in a fully integrated electromagnetic cell sorting system

Suk Heung Song; Bong Seop Kwak; Jae Sung Park; Woochul Kim; Hyo IL Jung

doi:10.1016/j.sna.2009.02.006

Novel application of Joule heating to maintain biocompatible temperatures in a fully integrated electromagnetic cell sorting system

Suk Heung Song, Bong Seop Kwak, Jae Sung Park, Woochul Kim, Hyo IL Jung

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Manipulation of magnetically labeled cells in a microfluidic channel is becoming a very important technique in the field of biomedical science. A microfabricated electromagnet produces a large magnetic field gradient in a cell sorting system. The microfabricated electromagnet generates Joule heating so it causes unnecessary heat-up in the device, which has been problematic for the development of a Lab-On-a-Chip (LOC). In this paper, we present a new application of Joule heating to supply thermal energy to an active area of a microfluidic device to increase the internal temperature of the device from ambient to a biocompatible temperature, e.g. 37 °C. The temperature is maintained in conjunction with coolant. We analyzed the temperature distribution of the device numerically and the results were in good agreement with the experimental data. Our approach will facilitate development of cell chips such as a micro-mammalian cell culture or electromagnetic micro-cell sorter. Crown

Original language	English
Pages (from-to)	64-70
Number of pages	7
Journal	Sensors and Actuators, A: Physical
Volume	151
Issue number	1
DOIs	https://doi.org/10.1016/j.sna.2009.02.006
Publication status	Published - 2009 Apr 8

Bibliographical note

Funding Information:
This work was supported by National Core Research Center (NCRC) for Nanomedical Technology of the Korea Science & Engineering Foundation (Grant no. R15-2004-024-01001-0), Seoul Research & Business Development (Seoul R&BD Program, 11128) and Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2007-313-D00073 & KRF-2007-314-C00107).

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering

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10.1016/j.sna.2009.02.006

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abstract = "Manipulation of magnetically labeled cells in a microfluidic channel is becoming a very important technique in the field of biomedical science. A microfabricated electromagnet produces a large magnetic field gradient in a cell sorting system. The microfabricated electromagnet generates Joule heating so it causes unnecessary heat-up in the device, which has been problematic for the development of a Lab-On-a-Chip (LOC). In this paper, we present a new application of Joule heating to supply thermal energy to an active area of a microfluidic device to increase the internal temperature of the device from ambient to a biocompatible temperature, e.g. 37 °C. The temperature is maintained in conjunction with coolant. We analyzed the temperature distribution of the device numerically and the results were in good agreement with the experimental data. Our approach will facilitate development of cell chips such as a micro-mammalian cell culture or electromagnetic micro-cell sorter. Crown",

author = "Song, {Suk Heung} and Kwak, {Bong Seop} and Park, {Jae Sung} and Woochul Kim and Jung, {Hyo IL}",

note = "Funding Information: This work was supported by National Core Research Center (NCRC) for Nanomedical Technology of the Korea Science & Engineering Foundation (Grant no. R15-2004-024-01001-0), Seoul Research & Business Development (Seoul R&BD Program, 11128) and Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2007-313-D00073 & KRF-2007-314-C00107). ",

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AU - Kim, Woochul

AU - Jung, Hyo IL

N1 - Funding Information: This work was supported by National Core Research Center (NCRC) for Nanomedical Technology of the Korea Science & Engineering Foundation (Grant no. R15-2004-024-01001-0), Seoul Research & Business Development (Seoul R&BD Program, 11128) and Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2007-313-D00073 & KRF-2007-314-C00107).

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N2 - Manipulation of magnetically labeled cells in a microfluidic channel is becoming a very important technique in the field of biomedical science. A microfabricated electromagnet produces a large magnetic field gradient in a cell sorting system. The microfabricated electromagnet generates Joule heating so it causes unnecessary heat-up in the device, which has been problematic for the development of a Lab-On-a-Chip (LOC). In this paper, we present a new application of Joule heating to supply thermal energy to an active area of a microfluidic device to increase the internal temperature of the device from ambient to a biocompatible temperature, e.g. 37 °C. The temperature is maintained in conjunction with coolant. We analyzed the temperature distribution of the device numerically and the results were in good agreement with the experimental data. Our approach will facilitate development of cell chips such as a micro-mammalian cell culture or electromagnetic micro-cell sorter. Crown

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Novel application of Joule heating to maintain biocompatible temperatures in a fully integrated electromagnetic cell sorting system

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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