Novel cosmetic patches for wrinkle improvement: Retinyl retinoate- and ascorbic acid-loaded dissolving microneedles

M. Kim, H. Yang, H. Kim, H. Jung, Hyungil Jung

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Synopsis Objective To evaluate wrinkle improvement and safety of a novel cosmetic dissolving microneedle patches loaded with two active compounds with different hydrophilicities, namely ascorbic acid and retinyl retinoate. Methods Clinical studies were performed on 24 Korean women for 12 weeks. Patients in group A were treated with retinyl retinoate-loaded dissolving microneedle patches on the left eye crow's feet area, and patients in group B were treated with ascorbic acid-loaded patches on the right eye crow's feet area twice daily. Wrinkle improvement was evaluated by skin Visiometer SV 600. Results Both the retinyl retinoate- and ascorbic acid-loaded dissolving microneedle patches demonstrated statistically significant differences in all Visiometer R-values (P < 0.05). In particular, highly significant differences were shown at R1 (skin roughness) and R5 (arithmetic average roughness) (P < 0.001). Also, there were no side effects such as allergies or irritant contact dermatitis. Conclusion Retinyl retinoate and ascorbic acid were successfully loaded into dissolving microneedles and used to produce novel cosmetic patches. These novel patches can be used efficiently in cosmetics given their patient usability, safety and effectiveness in wrinkle improvement.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalInternational Journal of Cosmetic Science
Volume36
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Cosmetics
Ascorbic acid
Ascorbic Acid
Crows
Foot
Skin
Surface roughness
Dermatitis
Irritant Dermatitis
Allergies
Irritants
Contact Dermatitis
Hydrophilicity
Patient Safety
Hydrophobic and Hydrophilic Interactions
Hypersensitivity
Safety
retinyl retinoate

All Science Journal Classification (ASJC) codes

  • Chemistry (miscellaneous)
  • Ageing
  • Pharmaceutical Science
  • Drug Discovery
  • Dermatology
  • Colloid and Surface Chemistry

Cite this

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abstract = "Synopsis Objective To evaluate wrinkle improvement and safety of a novel cosmetic dissolving microneedle patches loaded with two active compounds with different hydrophilicities, namely ascorbic acid and retinyl retinoate. Methods Clinical studies were performed on 24 Korean women for 12 weeks. Patients in group A were treated with retinyl retinoate-loaded dissolving microneedle patches on the left eye crow's feet area, and patients in group B were treated with ascorbic acid-loaded patches on the right eye crow's feet area twice daily. Wrinkle improvement was evaluated by skin Visiometer SV 600. Results Both the retinyl retinoate- and ascorbic acid-loaded dissolving microneedle patches demonstrated statistically significant differences in all Visiometer R-values (P < 0.05). In particular, highly significant differences were shown at R1 (skin roughness) and R5 (arithmetic average roughness) (P < 0.001). Also, there were no side effects such as allergies or irritant contact dermatitis. Conclusion Retinyl retinoate and ascorbic acid were successfully loaded into dissolving microneedles and used to produce novel cosmetic patches. These novel patches can be used efficiently in cosmetics given their patient usability, safety and effectiveness in wrinkle improvement.",
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Novel cosmetic patches for wrinkle improvement : Retinyl retinoate- and ascorbic acid-loaded dissolving microneedles. / Kim, M.; Yang, H.; Kim, H.; Jung, H.; Jung, Hyungil.

In: International Journal of Cosmetic Science, Vol. 36, No. 3, 01.01.2014, p. 207-212.

Research output: Contribution to journalArticle

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AB - Synopsis Objective To evaluate wrinkle improvement and safety of a novel cosmetic dissolving microneedle patches loaded with two active compounds with different hydrophilicities, namely ascorbic acid and retinyl retinoate. Methods Clinical studies were performed on 24 Korean women for 12 weeks. Patients in group A were treated with retinyl retinoate-loaded dissolving microneedle patches on the left eye crow's feet area, and patients in group B were treated with ascorbic acid-loaded patches on the right eye crow's feet area twice daily. Wrinkle improvement was evaluated by skin Visiometer SV 600. Results Both the retinyl retinoate- and ascorbic acid-loaded dissolving microneedle patches demonstrated statistically significant differences in all Visiometer R-values (P < 0.05). In particular, highly significant differences were shown at R1 (skin roughness) and R5 (arithmetic average roughness) (P < 0.001). Also, there were no side effects such as allergies or irritant contact dermatitis. Conclusion Retinyl retinoate and ascorbic acid were successfully loaded into dissolving microneedles and used to produce novel cosmetic patches. These novel patches can be used efficiently in cosmetics given their patient usability, safety and effectiveness in wrinkle improvement.

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