Novel cyanine dyes with vinylsulfone group for labeling biomolecules

Jin Woo Park; Youngsoo Kim; Kee Jung Lee; Dong Jin Kim

doi:10.1021/bc200232d

Novel cyanine dyes with vinylsulfone group for labeling biomolecules

Jin Woo Park, Youngsoo Kim, Kee Jung Lee, Dong Jin Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Novel vinylsulfone cyanine dyes (em. 550-850 nm) were designed and synthesized for fluorescent labeling of biomolecules via 1,2-addition reaction in aqueous conditions. Due to the virtue of chemical structures of both fluorophore and reactive group, these dyes could be significantly stable and reactive in various aqueous/organic conditions. A wide variety of pH, temperature, buffer concentration, and protein were tested for the optimal labeling condition.

Original language	English
Pages (from-to)	350-362
Number of pages	13
Journal	Bioconjugate Chemistry
Volume	23
Issue number	3
DOIs	https://doi.org/10.1021/bc200232d
Publication status	Published - 2012 Mar 21

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomedical Engineering
Pharmacology
Pharmaceutical Science
Organic Chemistry

Access to Document

10.1021/bc200232d

Cite this

@article{46fddcd53831494d96628668a17ee316,

title = "Novel cyanine dyes with vinylsulfone group for labeling biomolecules",

abstract = "Novel vinylsulfone cyanine dyes (em. 550-850 nm) were designed and synthesized for fluorescent labeling of biomolecules via 1,2-addition reaction in aqueous conditions. Due to the virtue of chemical structures of both fluorophore and reactive group, these dyes could be significantly stable and reactive in various aqueous/organic conditions. A wide variety of pH, temperature, buffer concentration, and protein were tested for the optimal labeling condition.",

author = "Park, {Jin Woo} and Youngsoo Kim and Lee, {Kee Jung} and Kim, {Dong Jin}",

year = "2012",

month = mar,

day = "21",

doi = "10.1021/bc200232d",

language = "English",

volume = "23",

pages = "350--362",

journal = "Bioconjugate Chemistry",

issn = "1043-1802",

publisher = "American Chemical Society",

number = "3",

}

TY - JOUR

T1 - Novel cyanine dyes with vinylsulfone group for labeling biomolecules

AU - Park, Jin Woo

AU - Kim, Youngsoo

AU - Lee, Kee Jung

AU - Kim, Dong Jin

PY - 2012/3/21

Y1 - 2012/3/21

N2 - Novel vinylsulfone cyanine dyes (em. 550-850 nm) were designed and synthesized for fluorescent labeling of biomolecules via 1,2-addition reaction in aqueous conditions. Due to the virtue of chemical structures of both fluorophore and reactive group, these dyes could be significantly stable and reactive in various aqueous/organic conditions. A wide variety of pH, temperature, buffer concentration, and protein were tested for the optimal labeling condition.

AB - Novel vinylsulfone cyanine dyes (em. 550-850 nm) were designed and synthesized for fluorescent labeling of biomolecules via 1,2-addition reaction in aqueous conditions. Due to the virtue of chemical structures of both fluorophore and reactive group, these dyes could be significantly stable and reactive in various aqueous/organic conditions. A wide variety of pH, temperature, buffer concentration, and protein were tested for the optimal labeling condition.

UR - http://www.scopus.com/inward/record.url?scp=84863390893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863390893&partnerID=8YFLogxK

U2 - 10.1021/bc200232d

DO - 10.1021/bc200232d

M3 - Article

C2 - 22243689

AN - SCOPUS:84863390893

SN - 1043-1802

VL - 23

SP - 350

EP - 362

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

IS - 3

ER -

Novel cyanine dyes with vinylsulfone group for labeling biomolecules

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this