Novel cyanine dyes with vinylsulfone group for labeling biomolecules

Jin Woo Park, Youngsoo Kim, Kee Jung Lee, Dong Jin Kim

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Novel vinylsulfone cyanine dyes (em. 550-850 nm) were designed and synthesized for fluorescent labeling of biomolecules via 1,2-addition reaction in aqueous conditions. Due to the virtue of chemical structures of both fluorophore and reactive group, these dyes could be significantly stable and reactive in various aqueous/organic conditions. A wide variety of pH, temperature, buffer concentration, and protein were tested for the optimal labeling condition.

Original languageEnglish
Pages (from-to)350-362
Number of pages13
JournalBioconjugate Chemistry
Volume23
Issue number3
DOIs
Publication statusPublished - 2012 Mar 21

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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