Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships

Sujin Lee, Sony Marharjan, Jong Wha Jung, Nam Jung Kim, Kyeojin Kim, Young Taek Han, Changjin Lim, Hyun Jung Choi, Young Geun Kwon, Young Ger Suh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalArchives of pharmacal research
Volume35
Issue number3
DOIs
Publication statusPublished - 2012 Mar 1

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Carbasugars
Phytosterols
Endothelial cells
Human Umbilical Vein Endothelial Cells
Structure-Activity Relationship
Hydroxyl Radical
Apoptosis

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Lee, Sujin ; Marharjan, Sony ; Jung, Jong Wha ; Kim, Nam Jung ; Kim, Kyeojin ; Han, Young Taek ; Lim, Changjin ; Choi, Hyun Jung ; Kwon, Young Geun ; Suh, Young Ger. / Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues : Insight into their structure-activity relationships. In: Archives of pharmacal research. 2012 ; Vol. 35, No. 3. pp. 455-460.
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Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues : Insight into their structure-activity relationships. / Lee, Sujin; Marharjan, Sony; Jung, Jong Wha; Kim, Nam Jung; Kim, Kyeojin; Han, Young Taek; Lim, Changjin; Choi, Hyun Jung; Kwon, Young Geun; Suh, Young Ger.

In: Archives of pharmacal research, Vol. 35, No. 3, 01.03.2012, p. 455-460.

Research output: Contribution to journalArticle

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AU - Lee, Sujin

AU - Marharjan, Sony

AU - Jung, Jong Wha

AU - Kim, Nam Jung

AU - Kim, Kyeojin

AU - Han, Young Taek

AU - Lim, Changjin

AU - Choi, Hyun Jung

AU - Kwon, Young Geun

AU - Suh, Young Ger

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