Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships

Sujin Lee, Sony Marharjan, Jong Wha Jung, Nam Jung Kim, Kyeojin Kim, Young Taek Han, Changjin Lim, Hyun Jung Choi, Young Geun Kwon, Young Ger Suh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalArchives of pharmacal research
Volume35
Issue number3
DOIs
Publication statusPublished - 2012 Mar

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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