Novel methods for clinical risk stratification in patients with colorectal liver metastases

Ki Yeol Kim, Nam Kyu Kim, In Ho Cha, Joong Bae Ahn, Jin Sub Choi, Gi Hong Choi, Joon Suk Lim, Kang Young Lee, Seung Hyuk Baik, Byung Soh Min, Hyuk Hur, Jae Kyung Roh, Sang Joon Shin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose Colorectal cancer patients with liver-confined metastases are classified as stage IV, but their prognoses can differ from metastases at other sites. In this study, we suggest a novel method for risk stratification using clinically effective factors. Materials and Methods Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. This analysis was based on principal component analysis (PCA). Results The survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio, 1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval (DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups according to PCA score using significantly affected factors, they showed significantly different survival patterns (p < 0.001). Conclusion The PCA scoring system based on CEA level, distribution of liver metastasis, and DFI may be useful for preoperatively determining prognoses in order to assist in clinical decisionmaking and designing future clinical trials for CLM treatment.

Original languageEnglish
Pages (from-to)242-250
Number of pages9
JournalCancer Research and Treatment
Volume47
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

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Neoplasm Metastasis
Liver
Principal Component Analysis
Carcinoembryonic Antigen
Odds Ratio
Colorectal Neoplasms
Survival Rate
Clinical Trials
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kim, Ki Yeol ; Kim, Nam Kyu ; Cha, In Ho ; Ahn, Joong Bae ; Choi, Jin Sub ; Choi, Gi Hong ; Lim, Joon Suk ; Lee, Kang Young ; Baik, Seung Hyuk ; Min, Byung Soh ; Hur, Hyuk ; Roh, Jae Kyung ; Shin, Sang Joon. / Novel methods for clinical risk stratification in patients with colorectal liver metastases. In: Cancer Research and Treatment. 2015 ; Vol. 47, No. 2. pp. 242-250.
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title = "Novel methods for clinical risk stratification in patients with colorectal liver metastases",
abstract = "Purpose Colorectal cancer patients with liver-confined metastases are classified as stage IV, but their prognoses can differ from metastases at other sites. In this study, we suggest a novel method for risk stratification using clinically effective factors. Materials and Methods Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. This analysis was based on principal component analysis (PCA). Results The survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio, 1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval (DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups according to PCA score using significantly affected factors, they showed significantly different survival patterns (p < 0.001). Conclusion The PCA scoring system based on CEA level, distribution of liver metastasis, and DFI may be useful for preoperatively determining prognoses in order to assist in clinical decisionmaking and designing future clinical trials for CLM treatment.",
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Kim, KY, Kim, NK, Cha, IH, Ahn, JB, Choi, JS, Choi, GH, Lim, JS, Lee, KY, Baik, SH, Min, BS, Hur, H, Roh, JK & Shin, SJ 2015, 'Novel methods for clinical risk stratification in patients with colorectal liver metastases', Cancer Research and Treatment, vol. 47, no. 2, pp. 242-250. https://doi.org/10.4143/crt.2014.066

Novel methods for clinical risk stratification in patients with colorectal liver metastases. / Kim, Ki Yeol; Kim, Nam Kyu; Cha, In Ho; Ahn, Joong Bae; Choi, Jin Sub; Choi, Gi Hong; Lim, Joon Suk; Lee, Kang Young; Baik, Seung Hyuk; Min, Byung Soh; Hur, Hyuk; Roh, Jae Kyung; Shin, Sang Joon.

In: Cancer Research and Treatment, Vol. 47, No. 2, 01.01.2015, p. 242-250.

Research output: Contribution to journalArticle

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T1 - Novel methods for clinical risk stratification in patients with colorectal liver metastases

AU - Kim, Ki Yeol

AU - Kim, Nam Kyu

AU - Cha, In Ho

AU - Ahn, Joong Bae

AU - Choi, Jin Sub

AU - Choi, Gi Hong

AU - Lim, Joon Suk

AU - Lee, Kang Young

AU - Baik, Seung Hyuk

AU - Min, Byung Soh

AU - Hur, Hyuk

AU - Roh, Jae Kyung

AU - Shin, Sang Joon

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose Colorectal cancer patients with liver-confined metastases are classified as stage IV, but their prognoses can differ from metastases at other sites. In this study, we suggest a novel method for risk stratification using clinically effective factors. Materials and Methods Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. This analysis was based on principal component analysis (PCA). Results The survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio, 1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval (DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups according to PCA score using significantly affected factors, they showed significantly different survival patterns (p < 0.001). Conclusion The PCA scoring system based on CEA level, distribution of liver metastasis, and DFI may be useful for preoperatively determining prognoses in order to assist in clinical decisionmaking and designing future clinical trials for CLM treatment.

AB - Purpose Colorectal cancer patients with liver-confined metastases are classified as stage IV, but their prognoses can differ from metastases at other sites. In this study, we suggest a novel method for risk stratification using clinically effective factors. Materials and Methods Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. This analysis was based on principal component analysis (PCA). Results The survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio, 1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval (DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups according to PCA score using significantly affected factors, they showed significantly different survival patterns (p < 0.001). Conclusion The PCA scoring system based on CEA level, distribution of liver metastasis, and DFI may be useful for preoperatively determining prognoses in order to assist in clinical decisionmaking and designing future clinical trials for CLM treatment.

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