Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer

Kyong Ah Yoon, Bin Hwangbo, Il Jin Kim, Sohee Park, Hee Sun Kim, Hyun Jung Kee, Jong Eun Lee, Yeun Kyu Jang, Jae Gahb Park, Jin Soo Lee

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Histone H3 lysine 9 (H3-K9) methylation and DNA methylation are important features of mammalian heterochromatin. Suppressor of variegation 3-9 homolog 2 (SUV39H2) is the histone methyltransferase that is required to methylate H3-K9, leading to transcriptional repression or silencing of target genes. In this study, we investigated the association of SUV39H2 polymorphisms and the risk of lung cancer. From the results of PCR direct sequencing, eight single nucleotide polymorphisms (SNPs) of SUV39H2 were identified in Korean population. In a hospital-based study of 346 lung cancer patients and 423 healthy controls, a novel SNP in the 3′-UTR of SUV39H2 (1624 G→C) was associated with a statistically significant increase in lung cancer risk. Compared to the G/G genotype, genotypes with 1624C allele (G/C + C/ C) significantly increased the susceptibility to lung cancer with adjusted odds ratio (AOR) of 2.63 (95% confidence interval (CI)= 1.10-6.29) for ever-smokers, especially in the older age group (age ≥55 years). Specifically, the variant genotype of 1624SNP was significantly associated with an increased risk of squamous cell carcinoma (AOR, 3.52; 95% CI = 1.13-9.45) in the older age group, while no significant association was found in patients with other histology. This study provided the first evidence that a novel SUV39H2 polymorphism may be an important predictive marker for lung cancer susceptibility for the smokers.

Original languageEnglish
Pages (from-to)2217-2222
Number of pages6
JournalCarcinogenesis
Volume27
Issue number11
DOIs
Publication statusPublished - 2006 Nov 15

Bibliographical note

Funding Information:
We thank Yeun Ho Choi and Jin Hee Kim (National Cancer Center) for their excellent technical assistance. This work was supported by the National Cancer Center Research Grant (0410110-1) (P.I. J.S.L.).

All Science Journal Classification (ASJC) codes

  • Cancer Research

Fingerprint Dive into the research topics of 'Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer'. Together they form a unique fingerprint.

Cite this