Novel Trajectories for Identifying Asthma Phenotypes: A Longitudinal Study in Korean Asthma Cohort, COREA

COREA investigators

doi:10.1016/j.jaip.2019.02.011

Novel Trajectories for Identifying Asthma Phenotypes: A Longitudinal Study in Korean Asthma Cohort, COREA

COREA investigators

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Background: Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability in airway inflammation. Objective: We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Methods: Data were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA). Three-year pulmonary function test results were used to apply finite mixture models for group-based trajectory in 486 patients with eligible data set. Results: Two main sets of longitudinal trajectories were identified in terms of FEV₁% predicted, and FEV₁ variability. In the 4 trajectories determined with FEV₁% predicted, the pulmonary function showed a consistent course in 4 stratified levels during 3 years of follow-up, which was associated with unexpected hospital visits and the use of steroid bursts due to exacerbation. The variability in pulmonary function showed 3 different patterns, and we found that higher blood and sputum eosinophil levels were associated with the higher variability in pulmonary function and more exacerbations. Conclusions: Trajectory analysis is a novel method that provides longitudinal asthma phenotypes and aids in prediction of future risk of exacerbation. Further analysis is needed to validate the usefulness of these trajectories in an independent population.

Original language	English
Pages (from-to)	1850-1857.e4
Journal	Journal of Allergy and Clinical Immunology: In Practice
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/j.jaip.2019.02.011
Publication status	Published - 2019 Jul 1

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare,Republic of Korea (grant no. HC15C1335). This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare,Republic of Korea (grant no. HC15C1335). We thank the members of the study centers for participating in this study. The COREA Study Group includes the following investigators: Tae-Bum Kim, Woo-Jung Song, Hyouk-Soo Kwon, and You Sook Cho (University of Ulsan, Seoul, Korea); Sae-Hoon Kim (Bundang Seoul National University, Seongnam, Korea); Byoung Whui Choi and Jae-Woo Jung (Chung-Ang University, Seoul, Korea); Young-Joo Cho and Min-Hye Kim (Ewha Womans University, Seoul, Korea); An-Soo Jang (Soonchunhyang University, Bucheon, Korea); Yoo Seob Shin (Ajou University, Suwon, Korea); Ji-Yong Moon (Hanyang University, Guri, Korea), Ho Joo Yoon (Hanyang University, Seoul, Korea), Jae-Woo Kwon (Kangwon National University, Chuncheon, Korea); Sang-Hoon Kim and So Young Park (Eulji University, Seoul, Korea); Taehoon Lee (University of Ulsan, Ulsan, Korea); Sujeong Kim (Kyungpook National University, Daegu, Korea); Chan Sun Park (Inje University, Haeundae Paik Hospital, Busan, Korea); Joo-Hee Kim (Hallym University, Sacred Heart Hospital, Anyang, Korea); Jeong-Hee Choi (Hallym University, Dongtan Sacred Heart Hospital, Hwaseong, Korea); Young-Hee Nam (Dong-A University, Busan, Korea); Sun-Young Yoon (University of Konkuk, Chungju, Korea); Hyun Jung Jin (Yeungnam University, Daegu, Korea); Min-Suk Yang (Seoul National University, Boramae Medical Center, Seoul, Korea); Jaechun Lee (Jeju National University, Jeju, Korea); Hye-Kyung Park (Pusan National University, Busan, Korea); Gyu Young Hur (Korea University, Seoul, Korea); Hee-Kyoo Kim (Kosin University, Busan, Korea); and Sang Ha Kim (Yonsei University, Wonju, Korea). This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare,Republic of Korea (grant no. HC15C1335).

Publisher Copyright:
© 2019 American Academy of Allergy, Asthma & Immunology

All Science Journal Classification (ASJC) codes

Immunology and Allergy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaip.2019.02.011

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@article{f2f8438b43554667b48bbede9927568d,

title = "Novel Trajectories for Identifying Asthma Phenotypes: A Longitudinal Study in Korean Asthma Cohort, COREA",

abstract = "Background: Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability in airway inflammation. Objective: We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Methods: Data were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA). Three-year pulmonary function test results were used to apply finite mixture models for group-based trajectory in 486 patients with eligible data set. Results: Two main sets of longitudinal trajectories were identified in terms of FEV1% predicted, and FEV1 variability. In the 4 trajectories determined with FEV1% predicted, the pulmonary function showed a consistent course in 4 stratified levels during 3 years of follow-up, which was associated with unexpected hospital visits and the use of steroid bursts due to exacerbation. The variability in pulmonary function showed 3 different patterns, and we found that higher blood and sputum eosinophil levels were associated with the higher variability in pulmonary function and more exacerbations. Conclusions: Trajectory analysis is a novel method that provides longitudinal asthma phenotypes and aids in prediction of future risk of exacerbation. Further analysis is needed to validate the usefulness of these trajectories in an independent population.",

author = "{COREA investigators} and Park, {So Young} and Jung, {Hee Won} and Lee, {Jae Moon} and Bomi Shin and Kim, {Hyo Jung} and Kim, {Min Hye} and Song, {Woo Jung} and Kwon, {Hyouk Soo} and Jung, {Jae Woo} and Kim, {Sae Hoon} and Park, {Heung Woo} and Jang, {An Soo} and Chang, {Yoon Seok} and Cho, {You Sook} and Cho, {Young Joo} and Cho, {Sang Heon} and Choi, {Byoung Whui} and Sungho Won and Taesung Park and Moon, {Hee Bom} and Changsoo Kim and Kim, {Tae Bum} and Shin, {Yoo Seob} and Moon, {Ji Yong} and Kwon, {Jae Woo} and Kim, {Sang Hoon} and Taehoon Lee and Sujeong Kim and Park, {Chan Sun} and Kim, {Joo Hee} and Choi, {Jeong Hee} and Nam, {Young Hee} and Yoon, {Sun Young} and Jin, {Hyun Jung} and Yang, {Min Suk} and Jaechun Lee and Park, {Hye Kyung} and Hur, {Gyu Young} and Kim, {Hee Kyoo} and Kim, {Sang Ha}",

note = "Funding Information: This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare,Republic of Korea (grant no. HC15C1335). This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare,Republic of Korea (grant no. HC15C1335). We thank the members of the study centers for participating in this study. The COREA Study Group includes the following investigators: Tae-Bum Kim, Woo-Jung Song, Hyouk-Soo Kwon, and You Sook Cho (University of Ulsan, Seoul, Korea); Sae-Hoon Kim (Bundang Seoul National University, Seongnam, Korea); Byoung Whui Choi and Jae-Woo Jung (Chung-Ang University, Seoul, Korea); Young-Joo Cho and Min-Hye Kim (Ewha Womans University, Seoul, Korea); An-Soo Jang (Soonchunhyang University, Bucheon, Korea); Yoo Seob Shin (Ajou University, Suwon, Korea); Ji-Yong Moon (Hanyang University, Guri, Korea), Ho Joo Yoon (Hanyang University, Seoul, Korea), Jae-Woo Kwon (Kangwon National University, Chuncheon, Korea); Sang-Hoon Kim and So Young Park (Eulji University, Seoul, Korea); Taehoon Lee (University of Ulsan, Ulsan, Korea); Sujeong Kim (Kyungpook National University, Daegu, Korea); Chan Sun Park (Inje University, Haeundae Paik Hospital, Busan, Korea); Joo-Hee Kim (Hallym University, Sacred Heart Hospital, Anyang, Korea); Jeong-Hee Choi (Hallym University, Dongtan Sacred Heart Hospital, Hwaseong, Korea); Young-Hee Nam (Dong-A University, Busan, Korea); Sun-Young Yoon (University of Konkuk, Chungju, Korea); Hyun Jung Jin (Yeungnam University, Daegu, Korea); Min-Suk Yang (Seoul National University, Boramae Medical Center, Seoul, Korea); Jaechun Lee (Jeju National University, Jeju, Korea); Hye-Kyung Park (Pusan National University, Busan, Korea); Gyu Young Hur (Korea University, Seoul, Korea); Hee-Kyoo Kim (Kosin University, Busan, Korea); and Sang Ha Kim (Yonsei University, Wonju, Korea). This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare,Republic of Korea (grant no. HC15C1335). Publisher Copyright: {\textcopyright} 2019 American Academy of Allergy, Asthma & Immunology",

year = "2019",

month = jul,

day = "1",

doi = "10.1016/j.jaip.2019.02.011",

language = "English",

volume = "7",

pages = "1850--1857.e4",

journal = "Journal of Allergy and Clinical Immunology: In Practice",

issn = "2213-2198",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Novel Trajectories for Identifying Asthma Phenotypes

T2 - A Longitudinal Study in Korean Asthma Cohort, COREA

AU - COREA investigators

AU - Park, So Young

AU - Jung, Hee Won

AU - Lee, Jae Moon

AU - Shin, Bomi

AU - Kim, Hyo Jung

AU - Kim, Min Hye

AU - Song, Woo Jung

AU - Kwon, Hyouk Soo

AU - Jung, Jae Woo

AU - Kim, Sae Hoon

AU - Park, Heung Woo

AU - Jang, An Soo

AU - Chang, Yoon Seok

AU - Cho, You Sook

AU - Cho, Young Joo

AU - Cho, Sang Heon

AU - Choi, Byoung Whui

AU - Won, Sungho

AU - Park, Taesung

AU - Moon, Hee Bom

AU - Kim, Changsoo

AU - Kim, Tae Bum

AU - Shin, Yoo Seob

AU - Moon, Ji Yong

AU - Kwon, Jae Woo

AU - Kim, Sang Hoon

AU - Lee, Taehoon

AU - Kim, Sujeong

AU - Park, Chan Sun

AU - Kim, Joo Hee

AU - Choi, Jeong Hee

AU - Nam, Young Hee

AU - Yoon, Sun Young

AU - Jin, Hyun Jung

AU - Yang, Min Suk

AU - Lee, Jaechun

AU - Park, Hye Kyung

AU - Hur, Gyu Young

AU - Kim, Hee Kyoo

AU - Kim, Sang Ha

N1 - Funding Information: This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare,Republic of Korea (grant no. HC15C1335). This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare,Republic of Korea (grant no. HC15C1335). We thank the members of the study centers for participating in this study. The COREA Study Group includes the following investigators: Tae-Bum Kim, Woo-Jung Song, Hyouk-Soo Kwon, and You Sook Cho (University of Ulsan, Seoul, Korea); Sae-Hoon Kim (Bundang Seoul National University, Seongnam, Korea); Byoung Whui Choi and Jae-Woo Jung (Chung-Ang University, Seoul, Korea); Young-Joo Cho and Min-Hye Kim (Ewha Womans University, Seoul, Korea); An-Soo Jang (Soonchunhyang University, Bucheon, Korea); Yoo Seob Shin (Ajou University, Suwon, Korea); Ji-Yong Moon (Hanyang University, Guri, Korea), Ho Joo Yoon (Hanyang University, Seoul, Korea), Jae-Woo Kwon (Kangwon National University, Chuncheon, Korea); Sang-Hoon Kim and So Young Park (Eulji University, Seoul, Korea); Taehoon Lee (University of Ulsan, Ulsan, Korea); Sujeong Kim (Kyungpook National University, Daegu, Korea); Chan Sun Park (Inje University, Haeundae Paik Hospital, Busan, Korea); Joo-Hee Kim (Hallym University, Sacred Heart Hospital, Anyang, Korea); Jeong-Hee Choi (Hallym University, Dongtan Sacred Heart Hospital, Hwaseong, Korea); Young-Hee Nam (Dong-A University, Busan, Korea); Sun-Young Yoon (University of Konkuk, Chungju, Korea); Hyun Jung Jin (Yeungnam University, Daegu, Korea); Min-Suk Yang (Seoul National University, Boramae Medical Center, Seoul, Korea); Jaechun Lee (Jeju National University, Jeju, Korea); Hye-Kyung Park (Pusan National University, Busan, Korea); Gyu Young Hur (Korea University, Seoul, Korea); Hee-Kyoo Kim (Kosin University, Busan, Korea); and Sang Ha Kim (Yonsei University, Wonju, Korea). This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare,Republic of Korea (grant no. HC15C1335). Publisher Copyright: © 2019 American Academy of Allergy, Asthma & Immunology

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability in airway inflammation. Objective: We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Methods: Data were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA). Three-year pulmonary function test results were used to apply finite mixture models for group-based trajectory in 486 patients with eligible data set. Results: Two main sets of longitudinal trajectories were identified in terms of FEV1% predicted, and FEV1 variability. In the 4 trajectories determined with FEV1% predicted, the pulmonary function showed a consistent course in 4 stratified levels during 3 years of follow-up, which was associated with unexpected hospital visits and the use of steroid bursts due to exacerbation. The variability in pulmonary function showed 3 different patterns, and we found that higher blood and sputum eosinophil levels were associated with the higher variability in pulmonary function and more exacerbations. Conclusions: Trajectory analysis is a novel method that provides longitudinal asthma phenotypes and aids in prediction of future risk of exacerbation. Further analysis is needed to validate the usefulness of these trajectories in an independent population.

AB - Background: Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability in airway inflammation. Objective: We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Methods: Data were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA). Three-year pulmonary function test results were used to apply finite mixture models for group-based trajectory in 486 patients with eligible data set. Results: Two main sets of longitudinal trajectories were identified in terms of FEV1% predicted, and FEV1 variability. In the 4 trajectories determined with FEV1% predicted, the pulmonary function showed a consistent course in 4 stratified levels during 3 years of follow-up, which was associated with unexpected hospital visits and the use of steroid bursts due to exacerbation. The variability in pulmonary function showed 3 different patterns, and we found that higher blood and sputum eosinophil levels were associated with the higher variability in pulmonary function and more exacerbations. Conclusions: Trajectory analysis is a novel method that provides longitudinal asthma phenotypes and aids in prediction of future risk of exacerbation. Further analysis is needed to validate the usefulness of these trajectories in an independent population.

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UR - http://www.scopus.com/inward/citedby.url?scp=85063055178&partnerID=8YFLogxK

U2 - 10.1016/j.jaip.2019.02.011

DO - 10.1016/j.jaip.2019.02.011

M3 - Article

C2 - 30794966

AN - SCOPUS:85063055178

SN - 2213-2198

VL - 7

SP - 1850-1857.e4

JO - Journal of Allergy and Clinical Immunology: In Practice

JF - Journal of Allergy and Clinical Immunology: In Practice

IS - 6

ER -

Novel Trajectories for Identifying Asthma Phenotypes: A Longitudinal Study in Korean Asthma Cohort, COREA

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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