NT-proBNP

Is it a more significant risk factor for mortality than troponin T in incident hemodialysis Patients?

Hyung Jung Oh, Mi Jung Lee, Hye Sun Lee, Jung Tak Park, SeungHyeok Han, TaeHyun Yoo, Yong Lim Kim, Yon Su Kim, Chul Woo Yang, Nam Ho Kim, Shin-Wook Kang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Numerous studies have demonstrated that cardiac biomarkers are significant predictors of cardiovascular (CV) and all-cause mortality in ESRD patients, but most of the studies were retrospective or included small numbers of patients, only prevalent dialysis patients, or measured 1 or 2 biomarkers. This study was to analyze the association between 3 cardiac biomarkers and mortality in incident HD patients. A prospective cohort of 864 incident HD patients was followed for 30 months. Based on the median values of baseline NT-proBNP, cTnT, and hsCRP, the patientswere divided into "high" and "low" groups, andCV and all-causemortalitywere compared between each group. Additionally, time-dependentROC curveswere constructed, and theNRI and IDI of the models with various biomarkers were calculated. The CV survival rates were significantly lower in the "high" NT-proBNP and cTnT groups compared to the corresponding "low" groups, while there was no significant difference in CV survival rate between the 2 hsCRP groups. However, all-cause mortality rates were significantly higher in all 3 "high" groups compared to each lower group. In multivariate analyses, only Ln NT-proBNP was found to be an independent predictor of mortality. Moreover, NT-proBNP was a more prognostic marker for mortality compared to cTnT. In conclusion, NT-proBNP is the biomarker that results in the most added prognostic value on top of traditional risk factors for CV and all-cause mortality in incident HD patients.

Original languageEnglish
Article number241
JournalMedicine (United States)
Volume93
Issue number27
DOIs
Publication statusPublished - 2014 Dec 20

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Troponin T
Renal Dialysis
Biomarkers
Mortality
Survival Rate
Chronic Kidney Failure
pro-brain natriuretic peptide (1-76)
Dialysis
Multivariate Analysis
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Oh, Hyung Jung ; Lee, Mi Jung ; Lee, Hye Sun ; Park, Jung Tak ; Han, SeungHyeok ; Yoo, TaeHyun ; Kim, Yong Lim ; Kim, Yon Su ; Yang, Chul Woo ; Kim, Nam Ho ; Kang, Shin-Wook. / NT-proBNP : Is it a more significant risk factor for mortality than troponin T in incident hemodialysis Patients?. In: Medicine (United States). 2014 ; Vol. 93, No. 27.
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NT-proBNP : Is it a more significant risk factor for mortality than troponin T in incident hemodialysis Patients? / Oh, Hyung Jung; Lee, Mi Jung; Lee, Hye Sun; Park, Jung Tak; Han, SeungHyeok; Yoo, TaeHyun; Kim, Yong Lim; Kim, Yon Su; Yang, Chul Woo; Kim, Nam Ho; Kang, Shin-Wook.

In: Medicine (United States), Vol. 93, No. 27, 241, 20.12.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - NT-proBNP

T2 - Is it a more significant risk factor for mortality than troponin T in incident hemodialysis Patients?

AU - Oh, Hyung Jung

AU - Lee, Mi Jung

AU - Lee, Hye Sun

AU - Park, Jung Tak

AU - Han, SeungHyeok

AU - Yoo, TaeHyun

AU - Kim, Yong Lim

AU - Kim, Yon Su

AU - Yang, Chul Woo

AU - Kim, Nam Ho

AU - Kang, Shin-Wook

PY - 2014/12/20

Y1 - 2014/12/20

N2 - Numerous studies have demonstrated that cardiac biomarkers are significant predictors of cardiovascular (CV) and all-cause mortality in ESRD patients, but most of the studies were retrospective or included small numbers of patients, only prevalent dialysis patients, or measured 1 or 2 biomarkers. This study was to analyze the association between 3 cardiac biomarkers and mortality in incident HD patients. A prospective cohort of 864 incident HD patients was followed for 30 months. Based on the median values of baseline NT-proBNP, cTnT, and hsCRP, the patientswere divided into "high" and "low" groups, andCV and all-causemortalitywere compared between each group. Additionally, time-dependentROC curveswere constructed, and theNRI and IDI of the models with various biomarkers were calculated. The CV survival rates were significantly lower in the "high" NT-proBNP and cTnT groups compared to the corresponding "low" groups, while there was no significant difference in CV survival rate between the 2 hsCRP groups. However, all-cause mortality rates were significantly higher in all 3 "high" groups compared to each lower group. In multivariate analyses, only Ln NT-proBNP was found to be an independent predictor of mortality. Moreover, NT-proBNP was a more prognostic marker for mortality compared to cTnT. In conclusion, NT-proBNP is the biomarker that results in the most added prognostic value on top of traditional risk factors for CV and all-cause mortality in incident HD patients.

AB - Numerous studies have demonstrated that cardiac biomarkers are significant predictors of cardiovascular (CV) and all-cause mortality in ESRD patients, but most of the studies were retrospective or included small numbers of patients, only prevalent dialysis patients, or measured 1 or 2 biomarkers. This study was to analyze the association between 3 cardiac biomarkers and mortality in incident HD patients. A prospective cohort of 864 incident HD patients was followed for 30 months. Based on the median values of baseline NT-proBNP, cTnT, and hsCRP, the patientswere divided into "high" and "low" groups, andCV and all-causemortalitywere compared between each group. Additionally, time-dependentROC curveswere constructed, and theNRI and IDI of the models with various biomarkers were calculated. The CV survival rates were significantly lower in the "high" NT-proBNP and cTnT groups compared to the corresponding "low" groups, while there was no significant difference in CV survival rate between the 2 hsCRP groups. However, all-cause mortality rates were significantly higher in all 3 "high" groups compared to each lower group. In multivariate analyses, only Ln NT-proBNP was found to be an independent predictor of mortality. Moreover, NT-proBNP was a more prognostic marker for mortality compared to cTnT. In conclusion, NT-proBNP is the biomarker that results in the most added prognostic value on top of traditional risk factors for CV and all-cause mortality in incident HD patients.

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