Nutritional risk index as a predictor of mortality in acutely decompensated heart failure

Jae Yeong Cho, Kye Hun Kim, Hyun Jai Cho, Hae Young Lee, Jin Oh Choi, Eun Seok Jeon, Sang Eun Lee, Min Seok Kim, Jae Joong Kim, Kyung Kuk Hwang, Shung Chull Chae, Sang Hong Baek, seokmin kang, Dong Ju Choi, Byungsu Yoo, Youngkeun Ahn, Hyun Young Park, Myeong Chan Cho, Byung Hee Oh

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Abstract

Background We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF). Methods Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41.7 x weight [kg]/ideal body weight [kg])] were enrolled. The patients were divided into 4 groups according to the NRI quartile; Q1 <89 (n = 1121, 69.9 ± 14.5 years, 632 males), Q2 89–95 (n = 1234, 69.7 ± 14.4 years, 677 males), Q3 95–100 (n = 1199, 68.8 ± 14.0 years, 849 males), Q4 >100 (n = 1711, 65.6 ± 14.5 years, 779 males). Primary end-point was all-cause mortality at 1-year clinical follow-up. Results The 1-year mortality was significantly increased as the NRI quartile decreased, and the lowest NRI quartile was associated with the highest 1-year mortality (Q1: 27.5% vs. Q2: 20.9% vs. Q3: 12.9% vs. Q4: 8.7%, linear p <0.001). On Kaplan-Meier survival analysis, the significant inter-quartile difference was observed (p <0.001 for all). In multivariate analysis using Cox proportional hazard regression, the lowest NRI quartile was an independent predictor of 1-year mortality in patients with ADHF. Conclusions Poor nutritional status as assessed by NRI and quartile grading of NRI was associated with 1-year mortality in Korean patients with ADHF. The assessment of nutritional status by NRI may provide additional prognostic information and thus would be useful in the risk stratification of the patients with ADHF.

Original languageEnglish
Article numbere0209088
JournalPloS one
Volume13
Issue number12
DOIs
Publication statusPublished - 2018 Dec 1

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Nutrition Assessment
heart failure
Heart Failure
Mortality
Nutritional Status
nutritional status
ideal body weight
Ideal Body Weight
nutrition assessment
Kaplan-Meier Estimate
serum albumin
Survival Analysis
Serum Albumin
multivariate analysis
Registries
Hazards
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Cho, J. Y., Kim, K. H., Cho, H. J., Lee, H. Y., Choi, J. O., Jeon, E. S., ... Oh, B. H. (2018). Nutritional risk index as a predictor of mortality in acutely decompensated heart failure. PloS one, 13(12), [e0209088]. https://doi.org/10.1371/journal.pone.0209088
Cho, Jae Yeong ; Kim, Kye Hun ; Cho, Hyun Jai ; Lee, Hae Young ; Choi, Jin Oh ; Jeon, Eun Seok ; Lee, Sang Eun ; Kim, Min Seok ; Kim, Jae Joong ; Hwang, Kyung Kuk ; Chae, Shung Chull ; Baek, Sang Hong ; kang, seokmin ; Choi, Dong Ju ; Yoo, Byungsu ; Ahn, Youngkeun ; Park, Hyun Young ; Cho, Myeong Chan ; Oh, Byung Hee. / Nutritional risk index as a predictor of mortality in acutely decompensated heart failure. In: PloS one. 2018 ; Vol. 13, No. 12.
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abstract = "Background We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF). Methods Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41.7 x weight [kg]/ideal body weight [kg])] were enrolled. The patients were divided into 4 groups according to the NRI quartile; Q1 <89 (n = 1121, 69.9 ± 14.5 years, 632 males), Q2 89–95 (n = 1234, 69.7 ± 14.4 years, 677 males), Q3 95–100 (n = 1199, 68.8 ± 14.0 years, 849 males), Q4 >100 (n = 1711, 65.6 ± 14.5 years, 779 males). Primary end-point was all-cause mortality at 1-year clinical follow-up. Results The 1-year mortality was significantly increased as the NRI quartile decreased, and the lowest NRI quartile was associated with the highest 1-year mortality (Q1: 27.5{\%} vs. Q2: 20.9{\%} vs. Q3: 12.9{\%} vs. Q4: 8.7{\%}, linear p <0.001). On Kaplan-Meier survival analysis, the significant inter-quartile difference was observed (p <0.001 for all). In multivariate analysis using Cox proportional hazard regression, the lowest NRI quartile was an independent predictor of 1-year mortality in patients with ADHF. Conclusions Poor nutritional status as assessed by NRI and quartile grading of NRI was associated with 1-year mortality in Korean patients with ADHF. The assessment of nutritional status by NRI may provide additional prognostic information and thus would be useful in the risk stratification of the patients with ADHF.",
author = "Cho, {Jae Yeong} and Kim, {Kye Hun} and Cho, {Hyun Jai} and Lee, {Hae Young} and Choi, {Jin Oh} and Jeon, {Eun Seok} and Lee, {Sang Eun} and Kim, {Min Seok} and Kim, {Jae Joong} and Hwang, {Kyung Kuk} and Chae, {Shung Chull} and Baek, {Sang Hong} and seokmin kang and Choi, {Dong Ju} and Byungsu Yoo and Youngkeun Ahn and Park, {Hyun Young} and Cho, {Myeong Chan} and Oh, {Byung Hee}",
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Cho, JY, Kim, KH, Cho, HJ, Lee, HY, Choi, JO, Jeon, ES, Lee, SE, Kim, MS, Kim, JJ, Hwang, KK, Chae, SC, Baek, SH, kang, S, Choi, DJ, Yoo, B, Ahn, Y, Park, HY, Cho, MC & Oh, BH 2018, 'Nutritional risk index as a predictor of mortality in acutely decompensated heart failure', PloS one, vol. 13, no. 12, e0209088. https://doi.org/10.1371/journal.pone.0209088

Nutritional risk index as a predictor of mortality in acutely decompensated heart failure. / Cho, Jae Yeong; Kim, Kye Hun; Cho, Hyun Jai; Lee, Hae Young; Choi, Jin Oh; Jeon, Eun Seok; Lee, Sang Eun; Kim, Min Seok; Kim, Jae Joong; Hwang, Kyung Kuk; Chae, Shung Chull; Baek, Sang Hong; kang, seokmin; Choi, Dong Ju; Yoo, Byungsu; Ahn, Youngkeun; Park, Hyun Young; Cho, Myeong Chan; Oh, Byung Hee.

In: PloS one, Vol. 13, No. 12, e0209088, 01.12.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nutritional risk index as a predictor of mortality in acutely decompensated heart failure

AU - Cho, Jae Yeong

AU - Kim, Kye Hun

AU - Cho, Hyun Jai

AU - Lee, Hae Young

AU - Choi, Jin Oh

AU - Jeon, Eun Seok

AU - Lee, Sang Eun

AU - Kim, Min Seok

AU - Kim, Jae Joong

AU - Hwang, Kyung Kuk

AU - Chae, Shung Chull

AU - Baek, Sang Hong

AU - kang, seokmin

AU - Choi, Dong Ju

AU - Yoo, Byungsu

AU - Ahn, Youngkeun

AU - Park, Hyun Young

AU - Cho, Myeong Chan

AU - Oh, Byung Hee

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF). Methods Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41.7 x weight [kg]/ideal body weight [kg])] were enrolled. The patients were divided into 4 groups according to the NRI quartile; Q1 <89 (n = 1121, 69.9 ± 14.5 years, 632 males), Q2 89–95 (n = 1234, 69.7 ± 14.4 years, 677 males), Q3 95–100 (n = 1199, 68.8 ± 14.0 years, 849 males), Q4 >100 (n = 1711, 65.6 ± 14.5 years, 779 males). Primary end-point was all-cause mortality at 1-year clinical follow-up. Results The 1-year mortality was significantly increased as the NRI quartile decreased, and the lowest NRI quartile was associated with the highest 1-year mortality (Q1: 27.5% vs. Q2: 20.9% vs. Q3: 12.9% vs. Q4: 8.7%, linear p <0.001). On Kaplan-Meier survival analysis, the significant inter-quartile difference was observed (p <0.001 for all). In multivariate analysis using Cox proportional hazard regression, the lowest NRI quartile was an independent predictor of 1-year mortality in patients with ADHF. Conclusions Poor nutritional status as assessed by NRI and quartile grading of NRI was associated with 1-year mortality in Korean patients with ADHF. The assessment of nutritional status by NRI may provide additional prognostic information and thus would be useful in the risk stratification of the patients with ADHF.

AB - Background We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF). Methods Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41.7 x weight [kg]/ideal body weight [kg])] were enrolled. The patients were divided into 4 groups according to the NRI quartile; Q1 <89 (n = 1121, 69.9 ± 14.5 years, 632 males), Q2 89–95 (n = 1234, 69.7 ± 14.4 years, 677 males), Q3 95–100 (n = 1199, 68.8 ± 14.0 years, 849 males), Q4 >100 (n = 1711, 65.6 ± 14.5 years, 779 males). Primary end-point was all-cause mortality at 1-year clinical follow-up. Results The 1-year mortality was significantly increased as the NRI quartile decreased, and the lowest NRI quartile was associated with the highest 1-year mortality (Q1: 27.5% vs. Q2: 20.9% vs. Q3: 12.9% vs. Q4: 8.7%, linear p <0.001). On Kaplan-Meier survival analysis, the significant inter-quartile difference was observed (p <0.001 for all). In multivariate analysis using Cox proportional hazard regression, the lowest NRI quartile was an independent predictor of 1-year mortality in patients with ADHF. Conclusions Poor nutritional status as assessed by NRI and quartile grading of NRI was associated with 1-year mortality in Korean patients with ADHF. The assessment of nutritional status by NRI may provide additional prognostic information and thus would be useful in the risk stratification of the patients with ADHF.

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U2 - 10.1371/journal.pone.0209088

DO - 10.1371/journal.pone.0209088

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SN - 1932-6203

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