OASL1 inhibits translation of the type i interferon-regulating transcription factor IRF7

Myeong Sup Lee, Byungil Kim, Goo Taeg Oh, Young Joon Kim

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The production of type I interferon is essential for viral clearance but is kept under tight control to avoid unnecessary tissue damage from hyperinflammatory responses. Here we found that OASL1 inhibited translation of IRF7, the master transcription factor for type I interferon, and thus negatively regulated the robust production of type I interferon during viral infection. OASL1 inhibited the translation of IRF7 mRNA by binding to the 5′ untranslated region (UTR) of IRF7 and possibly by inhibiting scanning of the 43S preinitiation complex along the message. Oasl1-/- mice were resistant to viral infection because of the greater abundance of type I interferon, which suggests that OASL1 could be a potential therapeutic target for boosting the production of type I interferon during viral infection.

Original languageEnglish
Pages (from-to)346-355
Number of pages10
JournalNature Immunology
Volume14
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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