Obesity as a risk factor for prostatic enlargement: A retrospective cohort study in Korea

Jae Hung Jung, Song Vogue Ahn, Jae Mann Song, Se Jin Chang, Kwang Jin Kim, Sung Won Kwon, Sang Yoo Park, Sang Baek Koh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: We aimed to evaluate obesity, a risk factor of metabolic syndrome, and its association with prostatic enlargement in a retrospective cohort in Korea. Methods: Baseline data were obtained from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-ARIRANG). Between March 2015 and November 2015, 2,127 male participants of KoGES-ARIRANG were invited to the Korean Prostate Health Council Screening Program, and 602 participants underwent urological examination, including serum prostate specific antigen measurement and transrectal ultrasonography, and completed the International Prostate Symptom Score questionnaire. The data for 571 participants were analyzed, after excluding 31 men who had a history of prostatic disease or testosterone replacement, or had undergone a prior prostatic surgery or procedure. Results: Among components of metabolic syndrome, waist circumference had a statistically significant linear correlation with incremental increases in prostate volume (B=0.181, P=0.004). Abdominal obesity as determined by anthropometric measures including body mass index (odds ratio [OR], 1.205; 95% confidence interval [CI], 1.088-1.336), waist circumference (OR, 1.073; 95% CI, 1.032-1.115), body fat (OR, 1.126; 95% CI, 1.056-1.202), and visceral fat composition (OR, 1.667; 95% CI, 1.246-2.232) was significantly associated with the presence of high-volume benign prostatic hyperplasia (BPH) (prostate volume≥ 40 mL). Furthermore, the highest quartile of serum leptin (OR, 3.541; 95% CI, 1.103-11.365) and adiponectin levels (OR, 0.315; 95% CI, 0.102-0.971) were significantly correlated with high-volume BPH compared to the lowest quartile of levels. Conclusions: Abdominal obesity and serum leptin level are positively associated with prostate growth, whereas serum adiponectin level is inversely associated with the presence of prostatic enlargement.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalInternational Neurourology Journal
Volume20
Issue number4
DOIs
Publication statusPublished - 2016 Jan 1

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Korea
Cohort Studies
Retrospective Studies
Obesity
Odds Ratio
Prostate
Confidence Intervals
Abdominal Obesity
Adiponectin
Prostatic Hyperplasia
Waist Circumference
Leptin
Serum
Atherosclerosis
Epidemiology
Prostatic Diseases
Genome
Intra-Abdominal Fat
Prostate-Specific Antigen
Population

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Urology

Cite this

@article{f923d58c44ec45b7a2ced087465f1f58,
title = "Obesity as a risk factor for prostatic enlargement: A retrospective cohort study in Korea",
abstract = "Purpose: We aimed to evaluate obesity, a risk factor of metabolic syndrome, and its association with prostatic enlargement in a retrospective cohort in Korea. Methods: Baseline data were obtained from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-ARIRANG). Between March 2015 and November 2015, 2,127 male participants of KoGES-ARIRANG were invited to the Korean Prostate Health Council Screening Program, and 602 participants underwent urological examination, including serum prostate specific antigen measurement and transrectal ultrasonography, and completed the International Prostate Symptom Score questionnaire. The data for 571 participants were analyzed, after excluding 31 men who had a history of prostatic disease or testosterone replacement, or had undergone a prior prostatic surgery or procedure. Results: Among components of metabolic syndrome, waist circumference had a statistically significant linear correlation with incremental increases in prostate volume (B=0.181, P=0.004). Abdominal obesity as determined by anthropometric measures including body mass index (odds ratio [OR], 1.205; 95{\%} confidence interval [CI], 1.088-1.336), waist circumference (OR, 1.073; 95{\%} CI, 1.032-1.115), body fat (OR, 1.126; 95{\%} CI, 1.056-1.202), and visceral fat composition (OR, 1.667; 95{\%} CI, 1.246-2.232) was significantly associated with the presence of high-volume benign prostatic hyperplasia (BPH) (prostate volume≥ 40 mL). Furthermore, the highest quartile of serum leptin (OR, 3.541; 95{\%} CI, 1.103-11.365) and adiponectin levels (OR, 0.315; 95{\%} CI, 0.102-0.971) were significantly correlated with high-volume BPH compared to the lowest quartile of levels. Conclusions: Abdominal obesity and serum leptin level are positively associated with prostate growth, whereas serum adiponectin level is inversely associated with the presence of prostatic enlargement.",
author = "Jung, {Jae Hung} and Ahn, {Song Vogue} and Song, {Jae Mann} and Chang, {Se Jin} and Kim, {Kwang Jin} and Kwon, {Sung Won} and Park, {Sang Yoo} and Koh, {Sang Baek}",
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Obesity as a risk factor for prostatic enlargement : A retrospective cohort study in Korea. / Jung, Jae Hung; Ahn, Song Vogue; Song, Jae Mann; Chang, Se Jin; Kim, Kwang Jin; Kwon, Sung Won; Park, Sang Yoo; Koh, Sang Baek.

In: International Neurourology Journal, Vol. 20, No. 4, 01.01.2016, p. 321-328.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Obesity as a risk factor for prostatic enlargement

T2 - A retrospective cohort study in Korea

AU - Jung, Jae Hung

AU - Ahn, Song Vogue

AU - Song, Jae Mann

AU - Chang, Se Jin

AU - Kim, Kwang Jin

AU - Kwon, Sung Won

AU - Park, Sang Yoo

AU - Koh, Sang Baek

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Purpose: We aimed to evaluate obesity, a risk factor of metabolic syndrome, and its association with prostatic enlargement in a retrospective cohort in Korea. Methods: Baseline data were obtained from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-ARIRANG). Between March 2015 and November 2015, 2,127 male participants of KoGES-ARIRANG were invited to the Korean Prostate Health Council Screening Program, and 602 participants underwent urological examination, including serum prostate specific antigen measurement and transrectal ultrasonography, and completed the International Prostate Symptom Score questionnaire. The data for 571 participants were analyzed, after excluding 31 men who had a history of prostatic disease or testosterone replacement, or had undergone a prior prostatic surgery or procedure. Results: Among components of metabolic syndrome, waist circumference had a statistically significant linear correlation with incremental increases in prostate volume (B=0.181, P=0.004). Abdominal obesity as determined by anthropometric measures including body mass index (odds ratio [OR], 1.205; 95% confidence interval [CI], 1.088-1.336), waist circumference (OR, 1.073; 95% CI, 1.032-1.115), body fat (OR, 1.126; 95% CI, 1.056-1.202), and visceral fat composition (OR, 1.667; 95% CI, 1.246-2.232) was significantly associated with the presence of high-volume benign prostatic hyperplasia (BPH) (prostate volume≥ 40 mL). Furthermore, the highest quartile of serum leptin (OR, 3.541; 95% CI, 1.103-11.365) and adiponectin levels (OR, 0.315; 95% CI, 0.102-0.971) were significantly correlated with high-volume BPH compared to the lowest quartile of levels. Conclusions: Abdominal obesity and serum leptin level are positively associated with prostate growth, whereas serum adiponectin level is inversely associated with the presence of prostatic enlargement.

AB - Purpose: We aimed to evaluate obesity, a risk factor of metabolic syndrome, and its association with prostatic enlargement in a retrospective cohort in Korea. Methods: Baseline data were obtained from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-ARIRANG). Between March 2015 and November 2015, 2,127 male participants of KoGES-ARIRANG were invited to the Korean Prostate Health Council Screening Program, and 602 participants underwent urological examination, including serum prostate specific antigen measurement and transrectal ultrasonography, and completed the International Prostate Symptom Score questionnaire. The data for 571 participants were analyzed, after excluding 31 men who had a history of prostatic disease or testosterone replacement, or had undergone a prior prostatic surgery or procedure. Results: Among components of metabolic syndrome, waist circumference had a statistically significant linear correlation with incremental increases in prostate volume (B=0.181, P=0.004). Abdominal obesity as determined by anthropometric measures including body mass index (odds ratio [OR], 1.205; 95% confidence interval [CI], 1.088-1.336), waist circumference (OR, 1.073; 95% CI, 1.032-1.115), body fat (OR, 1.126; 95% CI, 1.056-1.202), and visceral fat composition (OR, 1.667; 95% CI, 1.246-2.232) was significantly associated with the presence of high-volume benign prostatic hyperplasia (BPH) (prostate volume≥ 40 mL). Furthermore, the highest quartile of serum leptin (OR, 3.541; 95% CI, 1.103-11.365) and adiponectin levels (OR, 0.315; 95% CI, 0.102-0.971) were significantly correlated with high-volume BPH compared to the lowest quartile of levels. Conclusions: Abdominal obesity and serum leptin level are positively associated with prostate growth, whereas serum adiponectin level is inversely associated with the presence of prostatic enlargement.

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