Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status

Ji Hye Huh, Kwang Joon Kim, Seungup Kim, Seung Hwan Han, KwangHyub Han, Bong Soo Cha, Choon Hee Chung, byungwan lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective The pathogenesis of non-alcoholic fatty liver disease (NAFLD) involves multiple concomitant events induced by obesity and metabolic health condition. This study aimed to assess the risk of NAFLD according to metabolic health and obesity status using transient elastography (TE). Materials and Methods A total of 2198 asymptomatic adults without chronic liver disease and who underwent a medical health check-up were recruited. Subjects were categorized into four groups according to metabolic health and obesity statuses: metabolically healthy non-obese (MHNO); metabolically unhealthy non-obese (MUNO); metabolically healthy obese (MHO); and metabolically unhealthy obese (MUO). Hepatic steatosis was defined as controlled attenuation parameter (CAP) ≥ 238 dB/m, and significant liver fibrosis was defined as liver stiffness measurement (LSM) > 7.0 kPa, as defined by TE. Results Compared with MHNO group, the odds ratios (ORs) [95% confidence interval (CI)] for hepatic steatosis were 2.94 [2.32–3.71], 4.62 [3.52–6.07], and 12.02 [9.08–15.92] in the MUNO, MHO, and MUO groups, respectively (P < 0.001) in crude model. Regarding liver fibrosis, there was no significant difference in the ORs in MUNO group (ORs: 0.95 [95% CI, 0.33–2.78], P value = 0.929), whereas there was a significant increase in the ORs in MHO group compared with MHNO group (ORs: 4.32 [95% CI, 1.73–10.76], P = 0.002) in the fully adjusted model. Conclusion Our results show that MHO was associated with both liver steatosis and fibrosis assessed by transient elastography. Our results suggest that a healthy metabolic profile does not protect obese adults from hepatic steatosis or fibrosis, indicating that obesity itself might contribute to liver fibrosis.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalMetabolism: Clinical and Experimental
Volume66
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Elasticity Imaging Techniques
Health Status
Fibrosis
Obesity
Liver Cirrhosis
Odds Ratio
Liver
Confidence Intervals
Metabolome
Health
Fatty Liver
Liver Diseases
Chronic Disease

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{13cad14162fa4c35a752dea64f22805b,
title = "Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status",
abstract = "Objective The pathogenesis of non-alcoholic fatty liver disease (NAFLD) involves multiple concomitant events induced by obesity and metabolic health condition. This study aimed to assess the risk of NAFLD according to metabolic health and obesity status using transient elastography (TE). Materials and Methods A total of 2198 asymptomatic adults without chronic liver disease and who underwent a medical health check-up were recruited. Subjects were categorized into four groups according to metabolic health and obesity statuses: metabolically healthy non-obese (MHNO); metabolically unhealthy non-obese (MUNO); metabolically healthy obese (MHO); and metabolically unhealthy obese (MUO). Hepatic steatosis was defined as controlled attenuation parameter (CAP) ≥ 238 dB/m, and significant liver fibrosis was defined as liver stiffness measurement (LSM) > 7.0 kPa, as defined by TE. Results Compared with MHNO group, the odds ratios (ORs) [95{\%} confidence interval (CI)] for hepatic steatosis were 2.94 [2.32–3.71], 4.62 [3.52–6.07], and 12.02 [9.08–15.92] in the MUNO, MHO, and MUO groups, respectively (P < 0.001) in crude model. Regarding liver fibrosis, there was no significant difference in the ORs in MUNO group (ORs: 0.95 [95{\%} CI, 0.33–2.78], P value = 0.929), whereas there was a significant increase in the ORs in MHO group compared with MHNO group (ORs: 4.32 [95{\%} CI, 1.73–10.76], P = 0.002) in the fully adjusted model. Conclusion Our results show that MHO was associated with both liver steatosis and fibrosis assessed by transient elastography. Our results suggest that a healthy metabolic profile does not protect obese adults from hepatic steatosis or fibrosis, indicating that obesity itself might contribute to liver fibrosis.",
author = "Huh, {Ji Hye} and Kim, {Kwang Joon} and Seungup Kim and Han, {Seung Hwan} and KwangHyub Han and Cha, {Bong Soo} and Chung, {Choon Hee} and byungwan lee",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.metabol.2016.10.003",
language = "English",
volume = "66",
pages = "23--31",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status

AU - Huh, Ji Hye

AU - Kim, Kwang Joon

AU - Kim, Seungup

AU - Han, Seung Hwan

AU - Han, KwangHyub

AU - Cha, Bong Soo

AU - Chung, Choon Hee

AU - lee, byungwan

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective The pathogenesis of non-alcoholic fatty liver disease (NAFLD) involves multiple concomitant events induced by obesity and metabolic health condition. This study aimed to assess the risk of NAFLD according to metabolic health and obesity status using transient elastography (TE). Materials and Methods A total of 2198 asymptomatic adults without chronic liver disease and who underwent a medical health check-up were recruited. Subjects were categorized into four groups according to metabolic health and obesity statuses: metabolically healthy non-obese (MHNO); metabolically unhealthy non-obese (MUNO); metabolically healthy obese (MHO); and metabolically unhealthy obese (MUO). Hepatic steatosis was defined as controlled attenuation parameter (CAP) ≥ 238 dB/m, and significant liver fibrosis was defined as liver stiffness measurement (LSM) > 7.0 kPa, as defined by TE. Results Compared with MHNO group, the odds ratios (ORs) [95% confidence interval (CI)] for hepatic steatosis were 2.94 [2.32–3.71], 4.62 [3.52–6.07], and 12.02 [9.08–15.92] in the MUNO, MHO, and MUO groups, respectively (P < 0.001) in crude model. Regarding liver fibrosis, there was no significant difference in the ORs in MUNO group (ORs: 0.95 [95% CI, 0.33–2.78], P value = 0.929), whereas there was a significant increase in the ORs in MHO group compared with MHNO group (ORs: 4.32 [95% CI, 1.73–10.76], P = 0.002) in the fully adjusted model. Conclusion Our results show that MHO was associated with both liver steatosis and fibrosis assessed by transient elastography. Our results suggest that a healthy metabolic profile does not protect obese adults from hepatic steatosis or fibrosis, indicating that obesity itself might contribute to liver fibrosis.

AB - Objective The pathogenesis of non-alcoholic fatty liver disease (NAFLD) involves multiple concomitant events induced by obesity and metabolic health condition. This study aimed to assess the risk of NAFLD according to metabolic health and obesity status using transient elastography (TE). Materials and Methods A total of 2198 asymptomatic adults without chronic liver disease and who underwent a medical health check-up were recruited. Subjects were categorized into four groups according to metabolic health and obesity statuses: metabolically healthy non-obese (MHNO); metabolically unhealthy non-obese (MUNO); metabolically healthy obese (MHO); and metabolically unhealthy obese (MUO). Hepatic steatosis was defined as controlled attenuation parameter (CAP) ≥ 238 dB/m, and significant liver fibrosis was defined as liver stiffness measurement (LSM) > 7.0 kPa, as defined by TE. Results Compared with MHNO group, the odds ratios (ORs) [95% confidence interval (CI)] for hepatic steatosis were 2.94 [2.32–3.71], 4.62 [3.52–6.07], and 12.02 [9.08–15.92] in the MUNO, MHO, and MUO groups, respectively (P < 0.001) in crude model. Regarding liver fibrosis, there was no significant difference in the ORs in MUNO group (ORs: 0.95 [95% CI, 0.33–2.78], P value = 0.929), whereas there was a significant increase in the ORs in MHO group compared with MHNO group (ORs: 4.32 [95% CI, 1.73–10.76], P = 0.002) in the fully adjusted model. Conclusion Our results show that MHO was associated with both liver steatosis and fibrosis assessed by transient elastography. Our results suggest that a healthy metabolic profile does not protect obese adults from hepatic steatosis or fibrosis, indicating that obesity itself might contribute to liver fibrosis.

UR - http://www.scopus.com/inward/record.url?scp=84994589962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994589962&partnerID=8YFLogxK

U2 - 10.1016/j.metabol.2016.10.003

DO - 10.1016/j.metabol.2016.10.003

M3 - Article

C2 - 27923446

AN - SCOPUS:84994589962

VL - 66

SP - 23

EP - 31

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

ER -