Objective-free optical-resolution photoacoustic microscopy

Chulhong Kim, Sungjo Park, Jongki Kim, Sungrae Lee, Changho Lee, Mansik Jeon, Jeehyun Kim, Kyunghwan Oh

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) becomes a premier microscopic imaging tool in biomedicine because it provides agent-free optical absorption information in tissues. By tightly focusing light to a spot, a significantly improved lateral resolution can be achieved in OR-PAM. The focal spot size is typically determined by the numerical aperture of the used objective lens. Here, we demonstrate objective-free OR-PAM using a fiber optic Bessel beam generator. In this approach, no objective lens is required and, beneficially, the complexities of conventional OR-PAM systems can be greatly relieved. We have obtained photoacoustic images of a carbon fiber with a diameter of ≪6 μm, whose lateral resolution was measured to be better than 6 to 7 μm.

Original languageEnglish
Article number010501
JournalJournal of Biomedical Optics
Volume18
Issue number1
DOIs
Publication statusPublished - 2013 Jul 8

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Photoacoustic microscopy
photoacoustic microscopy
Lenses
Photoacoustic effect
lenses
Light absorption
Fiber optics
Carbon fibers
numerical aperture
Tissue
carbon fibers
Imaging techniques
fiber optics
optical absorption
generators

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Kim, Chulhong ; Park, Sungjo ; Kim, Jongki ; Lee, Sungrae ; Lee, Changho ; Jeon, Mansik ; Kim, Jeehyun ; Oh, Kyunghwan. / Objective-free optical-resolution photoacoustic microscopy. In: Journal of Biomedical Optics. 2013 ; Vol. 18, No. 1.
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Kim, C, Park, S, Kim, J, Lee, S, Lee, C, Jeon, M, Kim, J & Oh, K 2013, 'Objective-free optical-resolution photoacoustic microscopy', Journal of Biomedical Optics, vol. 18, no. 1, 010501. https://doi.org/10.1117/1.JBO.18.1.010501

Objective-free optical-resolution photoacoustic microscopy. / Kim, Chulhong; Park, Sungjo; Kim, Jongki; Lee, Sungrae; Lee, Changho; Jeon, Mansik; Kim, Jeehyun; Oh, Kyunghwan.

In: Journal of Biomedical Optics, Vol. 18, No. 1, 010501, 08.07.2013.

Research output: Contribution to journalArticle

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