Objective-free optical-resolution photoacoustic microscopy

Chulhong Kim, Sungjo Park, Jongki Kim, Sungrae Lee, Changho Lee, Mansik Jeon, Jeehyun Kim, Kyunghwan Oh

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) becomes a premier microscopic imaging tool in biomedicine because it provides agent-free optical absorption information in tissues. By tightly focusing light to a spot, a significantly improved lateral resolution can be achieved in OR-PAM. The focal spot size is typically determined by the numerical aperture of the used objective lens. Here, we demonstrate objective-free OR-PAM using a fiber optic Bessel beam generator. In this approach, no objective lens is required and, beneficially, the complexities of conventional OR-PAM systems can be greatly relieved. We have obtained photoacoustic images of a carbon fiber with a diameter of ≪6 μm, whose lateral resolution was measured to be better than 6 to 7 μm.

Original languageEnglish
Article number010501
JournalJournal of Biomedical Optics
Volume18
Issue number1
DOIs
Publication statusPublished - 2013 Jul 8

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Objective-free optical-resolution photoacoustic microscopy'. Together they form a unique fingerprint.

  • Cite this

    Kim, C., Park, S., Kim, J., Lee, S., Lee, C., Jeon, M., Kim, J., & Oh, K. (2013). Objective-free optical-resolution photoacoustic microscopy. Journal of Biomedical Optics, 18(1), [010501]. https://doi.org/10.1117/1.JBO.18.1.010501