Observation of Cell Division in a Fertilized Egg of a Zebrafish by Using a Multimodal Nonlinear Optical Microscope

Sung Ho Lee, Seung Hyun Hong, Seung Han Park, Boram Kim, Dong Hee Kim, Seung Woo Park

Research output: Contribution to journalArticlepeer-review

Abstract

We have developed a high-speed and high-resolution multimodal nonlinear optical microscope, which can acquire in vivo label and label-free 3D images. Using this microscope, we could successfully observe dynamic images of the zebrafish heartbeat with 33-millisecond intervals without staining process, indicating 1.68 beats per second. In addition, we show that the label-free, high-speed, real-time images can be obtained during somatic cell divisions in the zebrafish’s embryo.

Original languageEnglish
Pages (from-to)485-489
Number of pages5
JournalJournal of the Korean Physical Society
Volume75
Issue number6
DOIs
Publication statusPublished - 2019 Sep 1

Bibliographical note

Funding Information:
This research was supported by the BK21 PLUS program and the Pioneer Research Center Program (20100002212) through the National Research Foundation (NRF) funded by the Ministry of Education of Korea.

Publisher Copyright:
© 2019, The Korean Physical Society.

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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