Observation of proliferation and attachment of three different cell types on nano-fibrous silk film & scaffold

Hyun Sook Baek, Young Hwan Park, Ki Chang Seok, Jong Chul Park, Dong Kyun Rah

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Attachment and viability of different cell types(fibrioblast, chondrocyte and osteoblast) was observed on two forms of silk (mat & Three-dimensional scaffolds). The osteoblasts behaviors cultured on silk mat were significantly higher than that found on 3-D silk fibroin scaffold (3-D SF scaffold). In the MTT assay, the cell viability of fibroblasts, chondrocyte and osteoblasts seeded on 2-D nanofiber mat was (2-D mat) significantly higher than that found on 3-D SF scaffold. Similar result could be seen from SEM observation and cell attachment study. However, alkaline phosphatase activity was significantly increased on 3-D SF scaffold than on2-D nanofiber.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2007 Apr 16


All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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