Octacosanol Supplementation Increases Running Endurance Time and Improves Biochemical Parameters after Exhaustion in Trained Rats

Hyunjung Kim, Sunghee Park, Dae Suk Han, Taesun Park

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This study evaluated the effects of octacosanol on running performance and related biochemical parameters in exercise-trained rats run to exhaustion on a treadmill. Male Sprague-Dawley rats were randomly assigned to one of three groups-sedentary control group (SC), exercise-trained control group (EC), and exercise-trained, octacosanol-supplemented group (EO)-and raised on either control or octacosanol (0.75%)-supplemented diet with (or without for SC rats) exercise-training for 4 weeks. EC rats ran 184% longer until exhaustion than SC rats (P < .01), while octacosanol-supplemented trained rats ran 46% longer than EC rats (P < .05). Under the exhausted state immediately following the running performance test, EO rats exhibited significantly higher plasma ammonia and lactate concentrations compared with the values for EC rats (P < .05). Although EO rats ran significantly longer until exhausted, their plasma glucose level and gastronecmius muscle glycogen concentration were not significantly different from those of EC rats. Dietary supplementation of octacosanol resulted in significantly higher creatine phosphokinase activity in plasma (44% increase, P < .01) and citrate synthase activity in muscle (16% increase, P < .01) of exercise-trained rats. These results suggest that the ergogenic properties of octacosanol include the sparing of muscle glycogen stores and increases in the oxidative capacity in the muscle of exercise-trained rats.

Original languageEnglish
Pages (from-to)345-351
Number of pages7
JournalJournal of medicinal food
Volume6
Issue number4
DOIs
Publication statusPublished - 2003 Jan 1

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Control Groups
Muscles
Glycogen
Running
1-octacosanol
Citrate (si)-Synthase
Creatine Kinase
Dietary Supplements
Ammonia
Sprague Dawley Rats
Lactic Acid
Exercise
Diet
Glucose

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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title = "Octacosanol Supplementation Increases Running Endurance Time and Improves Biochemical Parameters after Exhaustion in Trained Rats",
abstract = "This study evaluated the effects of octacosanol on running performance and related biochemical parameters in exercise-trained rats run to exhaustion on a treadmill. Male Sprague-Dawley rats were randomly assigned to one of three groups-sedentary control group (SC), exercise-trained control group (EC), and exercise-trained, octacosanol-supplemented group (EO)-and raised on either control or octacosanol (0.75{\%})-supplemented diet with (or without for SC rats) exercise-training for 4 weeks. EC rats ran 184{\%} longer until exhaustion than SC rats (P < .01), while octacosanol-supplemented trained rats ran 46{\%} longer than EC rats (P < .05). Under the exhausted state immediately following the running performance test, EO rats exhibited significantly higher plasma ammonia and lactate concentrations compared with the values for EC rats (P < .05). Although EO rats ran significantly longer until exhausted, their plasma glucose level and gastronecmius muscle glycogen concentration were not significantly different from those of EC rats. Dietary supplementation of octacosanol resulted in significantly higher creatine phosphokinase activity in plasma (44{\%} increase, P < .01) and citrate synthase activity in muscle (16{\%} increase, P < .01) of exercise-trained rats. These results suggest that the ergogenic properties of octacosanol include the sparing of muscle glycogen stores and increases in the oxidative capacity in the muscle of exercise-trained rats.",
author = "Hyunjung Kim and Sunghee Park and Han, {Dae Suk} and Taesun Park",
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Octacosanol Supplementation Increases Running Endurance Time and Improves Biochemical Parameters after Exhaustion in Trained Rats. / Kim, Hyunjung; Park, Sunghee; Han, Dae Suk; Park, Taesun.

In: Journal of medicinal food, Vol. 6, No. 4, 01.01.2003, p. 345-351.

Research output: Contribution to journalArticle

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