Odour identification test and its relation to cardiac 123I- metaiodobenzylguanidine in patients with drug induced parkinsonism

Hyu Lee Phil, Hyeon Yeo Seung, Woo Yong Seok, Joong Kim Yun

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We investigated olfactory function and its relation to cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in 15 patients with drug induced parkinsonism (DIP). The mean Cross Cultural Smell Identification (CCSI) score was significantly greater in patients with DIP than in those with Parkinson's disease (PD: 6.9 (1.6) vs 4.4 (2.2); p<0.001); however, the mean CCSI score in patients with DIP was not significantly different from controls. One patient with DIP, whose CCSI score was significantly reduced, also exhibited decreased cardiac MIBG uptake. DIP patients with CCSI scores within the normal range had normal cardiac MIBG uptake. Our study suggests that an olfactory function test may be a useful tool for detecting DIP unrelated to PD and for identifying patients with DIP who have subclinical PD.

Original languageEnglish
Pages (from-to)1250-1252
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume78
Issue number11
DOIs
Publication statusPublished - 2007 Nov 1

Fingerprint

Parkinsonian Disorders
Smell
Pharmaceutical Preparations
Odorants
Parkinson Disease
Reference Values

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

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abstract = "We investigated olfactory function and its relation to cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in 15 patients with drug induced parkinsonism (DIP). The mean Cross Cultural Smell Identification (CCSI) score was significantly greater in patients with DIP than in those with Parkinson's disease (PD: 6.9 (1.6) vs 4.4 (2.2); p<0.001); however, the mean CCSI score in patients with DIP was not significantly different from controls. One patient with DIP, whose CCSI score was significantly reduced, also exhibited decreased cardiac MIBG uptake. DIP patients with CCSI scores within the normal range had normal cardiac MIBG uptake. Our study suggests that an olfactory function test may be a useful tool for detecting DIP unrelated to PD and for identifying patients with DIP who have subclinical PD.",
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Odour identification test and its relation to cardiac 123I- metaiodobenzylguanidine in patients with drug induced parkinsonism. / Phil, Hyu Lee; Seung, Hyeon Yeo; Seok, Woo Yong; Yun, Joong Kim.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 78, No. 11, 01.11.2007, p. 1250-1252.

Research output: Contribution to journalArticle

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