"Off" gait freezing and temporal discrimination threshold in patients with Parkinson disease

Myung Sik Lee, Hyun Sook Kim, Chulhyoung Lyoo

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective: To investigate the relationship between temporal discrimination threshold (TDT) and "off" period gait freezing (OGF) in patients with fluctuating Parkinson disease (PD). Methods: TDT values were measured at the dorsum of the toes in 11 control subjects and 22 patients with PD with a wearing-off phenomenon (16 patients with OGF and 6 patients without OGF). Results: During the L-dopa "off" period, TDT values increased abnormally in both patient groups but were significantly higher in patients with OGF than in those without OGF. A positive correlation was found between the severity of OGF and TDT values measured by different point stimulation. In patients with OGF, a single dose of L-dopa treatment normalized TDT values and ameliorated OGF. Conclusions: Dopa-responsive abnormal discriminative sensory processing may be a possible cause of "off" period gait freezing observed in patients with fluctuating Parkinson disease.

Original languageEnglish
Pages (from-to)670-674
Number of pages5
JournalNeurology
Volume64
Issue number4
DOIs
Publication statusPublished - 2005 Feb 22

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Gait
Freezing
Parkinson Disease
Levodopa
Dihydroxyphenylalanine
Toes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

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abstract = "Objective: To investigate the relationship between temporal discrimination threshold (TDT) and {"}off{"} period gait freezing (OGF) in patients with fluctuating Parkinson disease (PD). Methods: TDT values were measured at the dorsum of the toes in 11 control subjects and 22 patients with PD with a wearing-off phenomenon (16 patients with OGF and 6 patients without OGF). Results: During the L-dopa {"}off{"} period, TDT values increased abnormally in both patient groups but were significantly higher in patients with OGF than in those without OGF. A positive correlation was found between the severity of OGF and TDT values measured by different point stimulation. In patients with OGF, a single dose of L-dopa treatment normalized TDT values and ameliorated OGF. Conclusions: Dopa-responsive abnormal discriminative sensory processing may be a possible cause of {"}off{"} period gait freezing observed in patients with fluctuating Parkinson disease.",
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"Off" gait freezing and temporal discrimination threshold in patients with Parkinson disease. / Lee, Myung Sik; Kim, Hyun Sook; Lyoo, Chulhyoung.

In: Neurology, Vol. 64, No. 4, 22.02.2005, p. 670-674.

Research output: Contribution to journalArticle

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