Off-Target 18 F-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation

Jae Yong Choi, Hanna Cho, Sung Jun Ahn, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyoo

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42 Citations (Scopus)

Abstract

Off-target binding in the basal ganglia is commonly observed in the 18 F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R 2 * MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent 18 F-AV-1451 PET and R 2 * MRI studies. A correlation analysis was performed for age, 18 F-AV-1451 binding, and R 2 * values. Results: There was an age-related increase in both 18 F-AV-1451 binding in the basal ganglia and R 2 * values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18 F-AV-1451 binding in the basal ganglia increased with R 2 * values. Conclusion: Off-target 18 F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalJournal of Nuclear Medicine
Volume59
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Bibliographical note

Funding Information:
This study was financially supported by the “Mirae Medical” Faculty Research Assistance Program of Yonsei University College of Medicine (grant no. 6-2016-0162), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (no. 2015R1C1A2A01054507), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2017R1A2B2006694), and a Nuclear R&D Program of the National Research Foundation of Korea (no. NRF-2016M2A2A7024357). No other potential conflict of interest relevant to this article was reported.

Publisher Copyright:
COPYRIGHT © 2018 by the Society of Nuclear Medicine and Molecular Imaging.

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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