OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer

Jae Hwan Kim, Soon Min Lee, Jong Hyuk Lee, Sohyun Chun, Byung Hee Kang, Sojung Kwak, Jae Seok Roe, Tae Wan Kim, Hyunsoo Kim, Woo Ho Kim, Eun Jung Cho, Hong Duk Youn

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3 Citations (Scopus)

Abstract

2-oxogluatrate and Fe(II)-dependent oxygenase domain-containing protein 1 (OGFOD1) was recently revealed to be a proline hydroxylase of RPS23 for translational termination. However, OGFOD1 is nuclear, whereas translational termination occurs in the cytoplasm, raising the possibility of another function of OGFOD1 in the nucleus. In this study, we demonstrate that OGFOD1 is involved in cell cycle regulation. OGFOD1 knockdown in MDA-MB-231 breast cancer cells significantly impeded cell proliferation and resulted in the accumulation of G1 and G2/M cells by decreasing the mRNA levels of G1/S transition- and G2/M-related transcription factors and their target genes. We also confirmed that OGFOD1 is highly expressed in breast cancer tissues by bioinformatic analysis and immunohistochemistry. Thus, we propose that OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer.

Original languageEnglish
Pages (from-to)19528-19541
Number of pages14
JournalOncotarget
Volume6
Issue number23
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Oncology

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    Kim, J. H., Lee, S. M., Lee, J. H., Chun, S., Kang, B. H., Kwak, S., Roe, J. S., Kim, T. W., Kim, H., Kim, W. H., Cho, E. J., & Youn, H. D. (2015). OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer. Oncotarget, 6(23), 19528-19541. https://doi.org/10.18632/oncotarget.3683