Old age and male sex are associated with increased risk of asymptomatic erosive esophagitis

Analysis of data from local health examinations by the Korean National Health Insurance Corporation

Jae Hee Cho, Heeman Kim, Geun Jun Ko, Myoung Lyeol Woo, Chang Mo Moon, Yu Jin Kim, Ki Jun Han, Si Young Song, Hyeon Geun Cho

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background and Aims: Silent gastroesophageal reflux disease (GERD) is often detected during routine screening esophagogastroduodenoscopy (EGD). However, the risk factors and clinical implications of silent GERD remain unclear. In the present study, we investigated the risk factors for asymptomatic erosive esophagitis by analyzing the local area health examination data. Methods: The Korean National Health Insurance Corporation provides a bi-annual health examination performed by qualified local hospitals for the early detection of cancer in medical insurance holders over 40years of age. Participants who completed self-reported questionnaires on health, followed by EGD at the Myongji Hospital (Goyang, Korea), were enrolled in this study. Results: The data of a total of 5301 participants who underwent EGD between January 2005 and December 2008 were analyzed. The prevalence of erosive esophagitis was 6%. In the multivariate analysis, erosive esophagitis was strongly associated with an age greater than 60years (odds ratio [OR]: 0.7, 95% confidence interval [CI]: 0.6-1.0), male sex (OR: 2.3, 95% CI: 1.7-3.0), hiatus hernia (OR: 2.9, 95% CI: 2.1-4.0), duodenal ulcer (OR: 1.6, 95% CI: 1.1-2.5), hypertension (OR: 1.5, 95% CI: 1.2-2.0), and smoking (OR: 1.4, 95% CI: 1.0-1.8). Of the 320 participants with erosive esophagitis, 145 (45.3%) were asymptomatic participants, and those who were more frequently greater than 60years (OR: 1.8, 95% CI: 1.1-3.1) and male (OR: 1.8, 95% CI: 1.1-3.2). Conclusions: Asymptomatic erosive esophagitis in adults older than 40years is strongly associated with old age (≥60years) and male sex compared with symptomatic erosive esophagitis.

Original languageEnglish
Pages (from-to)1034-1038
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number6
DOIs
Publication statusPublished - 2011 Jan 1

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Esophagitis
National Health Programs
Odds Ratio
Confidence Intervals
Health
Digestive System Endoscopy
Gastroesophageal Reflux
Hiatal Hernia
Sex Ratio
Korea
Duodenal Ulcer
Insurance
Early Detection of Cancer
Multivariate Analysis
Smoking
Hypertension

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Cho, Jae Hee ; Kim, Heeman ; Ko, Geun Jun ; Woo, Myoung Lyeol ; Moon, Chang Mo ; Kim, Yu Jin ; Han, Ki Jun ; Song, Si Young ; Cho, Hyeon Geun. / Old age and male sex are associated with increased risk of asymptomatic erosive esophagitis : Analysis of data from local health examinations by the Korean National Health Insurance Corporation. In: Journal of Gastroenterology and Hepatology (Australia). 2011 ; Vol. 26, No. 6. pp. 1034-1038.
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abstract = "Background and Aims: Silent gastroesophageal reflux disease (GERD) is often detected during routine screening esophagogastroduodenoscopy (EGD). However, the risk factors and clinical implications of silent GERD remain unclear. In the present study, we investigated the risk factors for asymptomatic erosive esophagitis by analyzing the local area health examination data. Methods: The Korean National Health Insurance Corporation provides a bi-annual health examination performed by qualified local hospitals for the early detection of cancer in medical insurance holders over 40years of age. Participants who completed self-reported questionnaires on health, followed by EGD at the Myongji Hospital (Goyang, Korea), were enrolled in this study. Results: The data of a total of 5301 participants who underwent EGD between January 2005 and December 2008 were analyzed. The prevalence of erosive esophagitis was 6{\%}. In the multivariate analysis, erosive esophagitis was strongly associated with an age greater than 60years (odds ratio [OR]: 0.7, 95{\%} confidence interval [CI]: 0.6-1.0), male sex (OR: 2.3, 95{\%} CI: 1.7-3.0), hiatus hernia (OR: 2.9, 95{\%} CI: 2.1-4.0), duodenal ulcer (OR: 1.6, 95{\%} CI: 1.1-2.5), hypertension (OR: 1.5, 95{\%} CI: 1.2-2.0), and smoking (OR: 1.4, 95{\%} CI: 1.0-1.8). Of the 320 participants with erosive esophagitis, 145 (45.3{\%}) were asymptomatic participants, and those who were more frequently greater than 60years (OR: 1.8, 95{\%} CI: 1.1-3.1) and male (OR: 1.8, 95{\%} CI: 1.1-3.2). Conclusions: Asymptomatic erosive esophagitis in adults older than 40years is strongly associated with old age (≥60years) and male sex compared with symptomatic erosive esophagitis.",
author = "Cho, {Jae Hee} and Heeman Kim and Ko, {Geun Jun} and Woo, {Myoung Lyeol} and Moon, {Chang Mo} and Kim, {Yu Jin} and Han, {Ki Jun} and Song, {Si Young} and Cho, {Hyeon Geun}",
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Old age and male sex are associated with increased risk of asymptomatic erosive esophagitis : Analysis of data from local health examinations by the Korean National Health Insurance Corporation. / Cho, Jae Hee; Kim, Heeman; Ko, Geun Jun; Woo, Myoung Lyeol; Moon, Chang Mo; Kim, Yu Jin; Han, Ki Jun; Song, Si Young; Cho, Hyeon Geun.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 26, No. 6, 01.01.2011, p. 1034-1038.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Old age and male sex are associated with increased risk of asymptomatic erosive esophagitis

T2 - Analysis of data from local health examinations by the Korean National Health Insurance Corporation

AU - Cho, Jae Hee

AU - Kim, Heeman

AU - Ko, Geun Jun

AU - Woo, Myoung Lyeol

AU - Moon, Chang Mo

AU - Kim, Yu Jin

AU - Han, Ki Jun

AU - Song, Si Young

AU - Cho, Hyeon Geun

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background and Aims: Silent gastroesophageal reflux disease (GERD) is often detected during routine screening esophagogastroduodenoscopy (EGD). However, the risk factors and clinical implications of silent GERD remain unclear. In the present study, we investigated the risk factors for asymptomatic erosive esophagitis by analyzing the local area health examination data. Methods: The Korean National Health Insurance Corporation provides a bi-annual health examination performed by qualified local hospitals for the early detection of cancer in medical insurance holders over 40years of age. Participants who completed self-reported questionnaires on health, followed by EGD at the Myongji Hospital (Goyang, Korea), were enrolled in this study. Results: The data of a total of 5301 participants who underwent EGD between January 2005 and December 2008 were analyzed. The prevalence of erosive esophagitis was 6%. In the multivariate analysis, erosive esophagitis was strongly associated with an age greater than 60years (odds ratio [OR]: 0.7, 95% confidence interval [CI]: 0.6-1.0), male sex (OR: 2.3, 95% CI: 1.7-3.0), hiatus hernia (OR: 2.9, 95% CI: 2.1-4.0), duodenal ulcer (OR: 1.6, 95% CI: 1.1-2.5), hypertension (OR: 1.5, 95% CI: 1.2-2.0), and smoking (OR: 1.4, 95% CI: 1.0-1.8). Of the 320 participants with erosive esophagitis, 145 (45.3%) were asymptomatic participants, and those who were more frequently greater than 60years (OR: 1.8, 95% CI: 1.1-3.1) and male (OR: 1.8, 95% CI: 1.1-3.2). Conclusions: Asymptomatic erosive esophagitis in adults older than 40years is strongly associated with old age (≥60years) and male sex compared with symptomatic erosive esophagitis.

AB - Background and Aims: Silent gastroesophageal reflux disease (GERD) is often detected during routine screening esophagogastroduodenoscopy (EGD). However, the risk factors and clinical implications of silent GERD remain unclear. In the present study, we investigated the risk factors for asymptomatic erosive esophagitis by analyzing the local area health examination data. Methods: The Korean National Health Insurance Corporation provides a bi-annual health examination performed by qualified local hospitals for the early detection of cancer in medical insurance holders over 40years of age. Participants who completed self-reported questionnaires on health, followed by EGD at the Myongji Hospital (Goyang, Korea), were enrolled in this study. Results: The data of a total of 5301 participants who underwent EGD between January 2005 and December 2008 were analyzed. The prevalence of erosive esophagitis was 6%. In the multivariate analysis, erosive esophagitis was strongly associated with an age greater than 60years (odds ratio [OR]: 0.7, 95% confidence interval [CI]: 0.6-1.0), male sex (OR: 2.3, 95% CI: 1.7-3.0), hiatus hernia (OR: 2.9, 95% CI: 2.1-4.0), duodenal ulcer (OR: 1.6, 95% CI: 1.1-2.5), hypertension (OR: 1.5, 95% CI: 1.2-2.0), and smoking (OR: 1.4, 95% CI: 1.0-1.8). Of the 320 participants with erosive esophagitis, 145 (45.3%) were asymptomatic participants, and those who were more frequently greater than 60years (OR: 1.8, 95% CI: 1.1-3.1) and male (OR: 1.8, 95% CI: 1.1-3.2). Conclusions: Asymptomatic erosive esophagitis in adults older than 40years is strongly associated with old age (≥60years) and male sex compared with symptomatic erosive esophagitis.

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