Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities

Vu Kim Thu, Nguyen Van Thang, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Hoai Nam, Phan Van Kiem, Chau Van Minh, Hoang Le Tuan Anh, Nanyoung Kim, Seonju Park, Seung Hyun Kim

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Abstract

Eight oleanane-type saponins, glomerulosides A-H, were isolated from leaves of Glochidion glomerulatum. All isolated compounds were evaluated for cytotoxic activity on four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7. Glomerulosides C and E, which contain a benzoyloxy group at C-22, showed significant cytotoxic activities against the A-549, HT-29, and OVCAR cancer cell lines with IC50 values ranging from 5.9 to 9.8 μM. Glomeruloside A showed cytotoxicity on HT-29 and OVCAR cell lines with IC50 values of 7.3 and 6.6 μM, respectively. Moreover, glomeruloside B exhibited significant activity on A-549 and HT-29 cancer cell lines with IC50 values of 9.7 and 7.5 μM. In contrast, glomerulosides F-H, lacking a benzoyloxy group, showed only moderate cytotoxic activity.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalPhytochemistry
Volume116
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Cite this

Thu, V. K., Van Thang, N., Nhiem, N. X., Tai, B. H., Nam, N. H., Van Kiem, P., Van Minh, C., Le Tuan Anh, H., Kim, N., Park, S., & Kim, S. H. (2015). Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities. Phytochemistry, 116(1), 213-220. https://doi.org/10.1016/j.phytochem.2015.05.001