Eight oleanane-type saponins, glomerulosides A-H, were isolated from leaves of Glochidion glomerulatum. All isolated compounds were evaluated for cytotoxic activity on four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7. Glomerulosides C and E, which contain a benzoyloxy group at C-22, showed significant cytotoxic activities against the A-549, HT-29, and OVCAR cancer cell lines with IC50 values ranging from 5.9 to 9.8 μM. Glomeruloside A showed cytotoxicity on HT-29 and OVCAR cell lines with IC50 values of 7.3 and 6.6 μM, respectively. Moreover, glomeruloside B exhibited significant activity on A-549 and HT-29 cancer cell lines with IC50 values of 9.7 and 7.5 μM. In contrast, glomerulosides F-H, lacking a benzoyloxy group, showed only moderate cytotoxic activity.
Bibliographical noteFunding Information:
This research was supported by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.01-2012.24 and the Global Leading Technology Program of the Office of Strategic R&D Planning (OSP) funded by the Ministry of Knowledge Economy, Republic of Korea (No. 10039320 ).
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Plant Science