Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities

Vu Kim Thu, Nguyen Van Thang, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Hoai Nam, Phan Van Kiem, Chau Van Minh, Hoang Le Tuan Anh, Nanyoung Kim, Seonju Park, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Eight oleanane-type saponins, glomerulosides A-H, were isolated from leaves of Glochidion glomerulatum. All isolated compounds were evaluated for cytotoxic activity on four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7. Glomerulosides C and E, which contain a benzoyloxy group at C-22, showed significant cytotoxic activities against the A-549, HT-29, and OVCAR cancer cell lines with IC50 values ranging from 5.9 to 9.8 μM. Glomeruloside A showed cytotoxicity on HT-29 and OVCAR cell lines with IC50 values of 7.3 and 6.6 μM, respectively. Moreover, glomeruloside B exhibited significant activity on A-549 and HT-29 cancer cell lines with IC50 values of 9.7 and 7.5 μM. In contrast, glomerulosides F-H, lacking a benzoyloxy group, showed only moderate cytotoxic activity.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalPhytochemistry
Volume116
Issue number1
DOIs
Publication statusPublished - 2015

Bibliographical note

Funding Information:
This research was supported by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.01-2012.24 and the Global Leading Technology Program of the Office of Strategic R&D Planning (OSP) funded by the Ministry of Knowledge Economy, Republic of Korea (No. 10039320 ).

Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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