Olfactory changes after endoscopic endonasal transsphenoidal approach for skull base tumors

Boo Young Kim, Seok-Gu Kang, Sung W. Kim, Yong K. Hong, Sin Soo Jeun, Soo W. Kim, Hyun B. Kim, Min Kim, Jae H. Maeng, Dong C. Lee, Jin H. Cho, Yong J. Park

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objectives/Hypothesis The increased number of endoscopic endonasal transsphenoidal approaches (EETSA) has been associated with sinonasal complications such as olfactory dysfunction. Current studies have compared preoperative and postoperative olfactory function according to surgical type and age. Study Design Retrospective review of medical records at a tertiary referral center. Methods Patients were divided into two groups according to surgical type and into four groups according to age. The two surgical groups were defined based on the bilateral nasoseptal flap technique (group A: right conventional nasoseptal flap and left modified nasoseptal rescure flap; group B: bilateral modified nasoseptal rescue flap). The four age groups were ≤ 30, 31-45, 46-60, and ≥ 61 years. Patients underwent preoperative olfactory function evaluation using a visual analogue scale (VAS), the Connecticut Chemosensory Clinical Research Center Test (CCCRC), and the Cross-Cultural Smell Identification Test (CCSIT). Repeat testing was performed 6-months postoperatively. Results A total of 226 patients who underwent binostril four-hand EETSA were included in this study. In both groups A and B, the olfactory function was significantly decreased according to CCCRC and CCSIT scores (P < 0.05). The VAS scores were significantly decreased in both groups (P < 0.05). The symptom scores and olfactory test results were significantly changed in >30-year-old patients who had undergone EETSA. Conclusion EETSA might contribute to olfactory dysfunction independent of surgery type. In addition, age may affect the restoration of olfaction after EETSA. Patients who plan to undergo EETSA must be informed that their olfaction may be impaired.

Original languageEnglish
Pages (from-to)2470-2475
Number of pages6
JournalLaryngoscope
Volume124
Issue number11
DOIs
Publication statusPublished - 2014 Nov 1

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Skull Base
Smell
Neoplasms
Visual Analog Scale
Research
Tertiary Care Centers
Medical Records
Retrospective Studies
Hand
Age Groups

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Kim, B. Y., Kang, S-G., Kim, S. W., Hong, Y. K., Jeun, S. S., Kim, S. W., ... Park, Y. J. (2014). Olfactory changes after endoscopic endonasal transsphenoidal approach for skull base tumors. Laryngoscope, 124(11), 2470-2475. https://doi.org/10.1002/lary.24674
Kim, Boo Young ; Kang, Seok-Gu ; Kim, Sung W. ; Hong, Yong K. ; Jeun, Sin Soo ; Kim, Soo W. ; Kim, Hyun B. ; Kim, Min ; Maeng, Jae H. ; Lee, Dong C. ; Cho, Jin H. ; Park, Yong J. / Olfactory changes after endoscopic endonasal transsphenoidal approach for skull base tumors. In: Laryngoscope. 2014 ; Vol. 124, No. 11. pp. 2470-2475.
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abstract = "Objectives/Hypothesis The increased number of endoscopic endonasal transsphenoidal approaches (EETSA) has been associated with sinonasal complications such as olfactory dysfunction. Current studies have compared preoperative and postoperative olfactory function according to surgical type and age. Study Design Retrospective review of medical records at a tertiary referral center. Methods Patients were divided into two groups according to surgical type and into four groups according to age. The two surgical groups were defined based on the bilateral nasoseptal flap technique (group A: right conventional nasoseptal flap and left modified nasoseptal rescure flap; group B: bilateral modified nasoseptal rescue flap). The four age groups were ≤ 30, 31-45, 46-60, and ≥ 61 years. Patients underwent preoperative olfactory function evaluation using a visual analogue scale (VAS), the Connecticut Chemosensory Clinical Research Center Test (CCCRC), and the Cross-Cultural Smell Identification Test (CCSIT). Repeat testing was performed 6-months postoperatively. Results A total of 226 patients who underwent binostril four-hand EETSA were included in this study. In both groups A and B, the olfactory function was significantly decreased according to CCCRC and CCSIT scores (P < 0.05). The VAS scores were significantly decreased in both groups (P < 0.05). The symptom scores and olfactory test results were significantly changed in >30-year-old patients who had undergone EETSA. Conclusion EETSA might contribute to olfactory dysfunction independent of surgery type. In addition, age may affect the restoration of olfaction after EETSA. Patients who plan to undergo EETSA must be informed that their olfaction may be impaired.",
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Kim, BY, Kang, S-G, Kim, SW, Hong, YK, Jeun, SS, Kim, SW, Kim, HB, Kim, M, Maeng, JH, Lee, DC, Cho, JH & Park, YJ 2014, 'Olfactory changes after endoscopic endonasal transsphenoidal approach for skull base tumors', Laryngoscope, vol. 124, no. 11, pp. 2470-2475. https://doi.org/10.1002/lary.24674

Olfactory changes after endoscopic endonasal transsphenoidal approach for skull base tumors. / Kim, Boo Young; Kang, Seok-Gu; Kim, Sung W.; Hong, Yong K.; Jeun, Sin Soo; Kim, Soo W.; Kim, Hyun B.; Kim, Min; Maeng, Jae H.; Lee, Dong C.; Cho, Jin H.; Park, Yong J.

In: Laryngoscope, Vol. 124, No. 11, 01.11.2014, p. 2470-2475.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Olfactory changes after endoscopic endonasal transsphenoidal approach for skull base tumors

AU - Kim, Boo Young

AU - Kang, Seok-Gu

AU - Kim, Sung W.

AU - Hong, Yong K.

AU - Jeun, Sin Soo

AU - Kim, Soo W.

AU - Kim, Hyun B.

AU - Kim, Min

AU - Maeng, Jae H.

AU - Lee, Dong C.

AU - Cho, Jin H.

AU - Park, Yong J.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Objectives/Hypothesis The increased number of endoscopic endonasal transsphenoidal approaches (EETSA) has been associated with sinonasal complications such as olfactory dysfunction. Current studies have compared preoperative and postoperative olfactory function according to surgical type and age. Study Design Retrospective review of medical records at a tertiary referral center. Methods Patients were divided into two groups according to surgical type and into four groups according to age. The two surgical groups were defined based on the bilateral nasoseptal flap technique (group A: right conventional nasoseptal flap and left modified nasoseptal rescure flap; group B: bilateral modified nasoseptal rescue flap). The four age groups were ≤ 30, 31-45, 46-60, and ≥ 61 years. Patients underwent preoperative olfactory function evaluation using a visual analogue scale (VAS), the Connecticut Chemosensory Clinical Research Center Test (CCCRC), and the Cross-Cultural Smell Identification Test (CCSIT). Repeat testing was performed 6-months postoperatively. Results A total of 226 patients who underwent binostril four-hand EETSA were included in this study. In both groups A and B, the olfactory function was significantly decreased according to CCCRC and CCSIT scores (P < 0.05). The VAS scores were significantly decreased in both groups (P < 0.05). The symptom scores and olfactory test results were significantly changed in >30-year-old patients who had undergone EETSA. Conclusion EETSA might contribute to olfactory dysfunction independent of surgery type. In addition, age may affect the restoration of olfaction after EETSA. Patients who plan to undergo EETSA must be informed that their olfaction may be impaired.

AB - Objectives/Hypothesis The increased number of endoscopic endonasal transsphenoidal approaches (EETSA) has been associated with sinonasal complications such as olfactory dysfunction. Current studies have compared preoperative and postoperative olfactory function according to surgical type and age. Study Design Retrospective review of medical records at a tertiary referral center. Methods Patients were divided into two groups according to surgical type and into four groups according to age. The two surgical groups were defined based on the bilateral nasoseptal flap technique (group A: right conventional nasoseptal flap and left modified nasoseptal rescure flap; group B: bilateral modified nasoseptal rescue flap). The four age groups were ≤ 30, 31-45, 46-60, and ≥ 61 years. Patients underwent preoperative olfactory function evaluation using a visual analogue scale (VAS), the Connecticut Chemosensory Clinical Research Center Test (CCCRC), and the Cross-Cultural Smell Identification Test (CCSIT). Repeat testing was performed 6-months postoperatively. Results A total of 226 patients who underwent binostril four-hand EETSA were included in this study. In both groups A and B, the olfactory function was significantly decreased according to CCCRC and CCSIT scores (P < 0.05). The VAS scores were significantly decreased in both groups (P < 0.05). The symptom scores and olfactory test results were significantly changed in >30-year-old patients who had undergone EETSA. Conclusion EETSA might contribute to olfactory dysfunction independent of surgery type. In addition, age may affect the restoration of olfaction after EETSA. Patients who plan to undergo EETSA must be informed that their olfaction may be impaired.

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