Olfactory dysfunction in Alzheimer's disease– and Lewy body–related cognitive impairment

Han Soo Yoo; Seun Jeon; Seok Jong Chung; Mijin Yun; Phil Hyu Lee; Young Ho Sohn; Alan C. Evans; Byoung Seok Ye

doi:10.1016/j.jalz.2018.05.010

Olfactory dysfunction in Alzheimer's disease– and Lewy body–related cognitive impairment

Han Soo Yoo, Seun Jeon, Seok Jong Chung, Mijin Yun, Phil Hyu Lee, Young Ho Sohn, Alan C. Evans, Byoung Seok Ye

Department of Neurology

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Introduction: Olfactory dysfunction is common in Alzheimer's disease– and Lewy body–related disorders, but its neural correlates have not been clearly elucidated. Methods: We retrospectively recruited 237 patients with Alzheimer's disease–related cognitive impairment (ADCI) and 217 with Lewy body–related cognitive impairment (LBCI). They were identically evaluated using the Cross-Cultural Smell Identification Test, neuropsychological tests, and brain magnetic resonance imaging. Results: LBCI had more severe olfactory dysfunction than ADCI. Patients with more severe cognitive dysfunction had worse olfactory function in both groups. In ADCI, lower Cross-Cultural Smell Identification Test scores correlated with a lower cortical thickness in brain regions typically affected in Alzheimer's disease, most prominently in the right parahippocampal cortex, whereas in LBCI, the scores correlated with white matter abnormalities in regions vulnerable to Lewy body, including subcortical regions of the orbitofrontal and frontoparietal cortices. Discussion: Our results suggest that cortical atrophy in ADCI and white matter abnormalities in LBCI play important roles in olfactory dysfunction.

Original language	English
Pages (from-to)	1243-1252
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	14
Issue number	10
DOIs	https://doi.org/10.1016/j.jalz.2018.05.010
Publication status	Published - 2018 Oct

Bibliographical note

Funding Information:
Funding Sources: This research was supported by a Faculty research grant from Yonsei University College of Medicine (6-2016-0080) and National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B1015044) and by a grant from Canadian Institute of Health Research (CIHR) awarded to A.C.E. (201085 & 247003). S.J. is the recipient of 2 fellowships that contribute to his support: Bourse Fonds de Recherche Sant? Qu?bec (FRQS, dossier 259605) and by Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute (240522).

Funding Information:
Funding Sources: This research was supported by a Faculty research grant from Yonsei University College of Medicine (6-2016-0080) and National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B1015044) and by a grant from Canadian Institute of Health Research (CIHR) awarded to A.C.E. (201085 & 247003). S.J. is the recipient of 2 fellowships that contribute to his support: Bourse Fonds de Recherche Santé Québec (FRQS, dossier 259605) and by Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute (240522).

Publisher Copyright:
© 2018 the Alzheimer's Association

All Science Journal Classification (ASJC) codes

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Health Policy
Developmental Neuroscience
Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jalz.2018.05.010

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title = "Olfactory dysfunction in Alzheimer's disease– and Lewy body–related cognitive impairment",

abstract = "Introduction: Olfactory dysfunction is common in Alzheimer's disease– and Lewy body–related disorders, but its neural correlates have not been clearly elucidated. Methods: We retrospectively recruited 237 patients with Alzheimer's disease–related cognitive impairment (ADCI) and 217 with Lewy body–related cognitive impairment (LBCI). They were identically evaluated using the Cross-Cultural Smell Identification Test, neuropsychological tests, and brain magnetic resonance imaging. Results: LBCI had more severe olfactory dysfunction than ADCI. Patients with more severe cognitive dysfunction had worse olfactory function in both groups. In ADCI, lower Cross-Cultural Smell Identification Test scores correlated with a lower cortical thickness in brain regions typically affected in Alzheimer's disease, most prominently in the right parahippocampal cortex, whereas in LBCI, the scores correlated with white matter abnormalities in regions vulnerable to Lewy body, including subcortical regions of the orbitofrontal and frontoparietal cortices. Discussion: Our results suggest that cortical atrophy in ADCI and white matter abnormalities in LBCI play important roles in olfactory dysfunction.",

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note = "Funding Information: Funding Sources: This research was supported by a Faculty research grant from Yonsei University College of Medicine (6-2016-0080) and National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B1015044) and by a grant from Canadian Institute of Health Research (CIHR) awarded to A.C.E. (201085 & 247003). S.J. is the recipient of 2 fellowships that contribute to his support: Bourse Fonds de Recherche Sant? Qu?bec (FRQS, dossier 259605) and by Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute (240522). Funding Information: Funding Sources: This research was supported by a Faculty research grant from Yonsei University College of Medicine (6-2016-0080) and National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B1015044) and by a grant from Canadian Institute of Health Research (CIHR) awarded to A.C.E. (201085 & 247003). S.J. is the recipient of 2 fellowships that contribute to his support: Bourse Fonds de Recherche Sant{\'e} Qu{\'e}bec (FRQS, dossier 259605) and by Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute (240522). Publisher Copyright: {\textcopyright} 2018 the Alzheimer's Association",

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AU - Lee, Phil Hyu

AU - Sohn, Young Ho

AU - Evans, Alan C.

AU - Ye, Byoung Seok

N1 - Funding Information: Funding Sources: This research was supported by a Faculty research grant from Yonsei University College of Medicine (6-2016-0080) and National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B1015044) and by a grant from Canadian Institute of Health Research (CIHR) awarded to A.C.E. (201085 & 247003). S.J. is the recipient of 2 fellowships that contribute to his support: Bourse Fonds de Recherche Sant? Qu?bec (FRQS, dossier 259605) and by Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute (240522). Funding Information: Funding Sources: This research was supported by a Faculty research grant from Yonsei University College of Medicine (6-2016-0080) and National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B1015044) and by a grant from Canadian Institute of Health Research (CIHR) awarded to A.C.E. (201085 & 247003). S.J. is the recipient of 2 fellowships that contribute to his support: Bourse Fonds de Recherche Santé Québec (FRQS, dossier 259605) and by Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute (240522). Publisher Copyright: © 2018 the Alzheimer's Association

PY - 2018/10

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N2 - Introduction: Olfactory dysfunction is common in Alzheimer's disease– and Lewy body–related disorders, but its neural correlates have not been clearly elucidated. Methods: We retrospectively recruited 237 patients with Alzheimer's disease–related cognitive impairment (ADCI) and 217 with Lewy body–related cognitive impairment (LBCI). They were identically evaluated using the Cross-Cultural Smell Identification Test, neuropsychological tests, and brain magnetic resonance imaging. Results: LBCI had more severe olfactory dysfunction than ADCI. Patients with more severe cognitive dysfunction had worse olfactory function in both groups. In ADCI, lower Cross-Cultural Smell Identification Test scores correlated with a lower cortical thickness in brain regions typically affected in Alzheimer's disease, most prominently in the right parahippocampal cortex, whereas in LBCI, the scores correlated with white matter abnormalities in regions vulnerable to Lewy body, including subcortical regions of the orbitofrontal and frontoparietal cortices. Discussion: Our results suggest that cortical atrophy in ADCI and white matter abnormalities in LBCI play important roles in olfactory dysfunction.

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Olfactory dysfunction in Alzheimer's disease– and Lewy body–related cognitive impairment

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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