Olfactory dysfunction in Alzheimer's disease– and Lewy body–related cognitive impairment

Han Soo Yoo, Seun Jeon, Seok Jong Chung, Mijin Yun, Phil Hyu Lee, Young Ho Sohn, Alan C. Evans, Byoung Seok Ye

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Introduction: Olfactory dysfunction is common in Alzheimer's disease– and Lewy body–related disorders, but its neural correlates have not been clearly elucidated. Methods: We retrospectively recruited 237 patients with Alzheimer's disease–related cognitive impairment (ADCI) and 217 with Lewy body–related cognitive impairment (LBCI). They were identically evaluated using the Cross-Cultural Smell Identification Test, neuropsychological tests, and brain magnetic resonance imaging. Results: LBCI had more severe olfactory dysfunction than ADCI. Patients with more severe cognitive dysfunction had worse olfactory function in both groups. In ADCI, lower Cross-Cultural Smell Identification Test scores correlated with a lower cortical thickness in brain regions typically affected in Alzheimer's disease, most prominently in the right parahippocampal cortex, whereas in LBCI, the scores correlated with white matter abnormalities in regions vulnerable to Lewy body, including subcortical regions of the orbitofrontal and frontoparietal cortices. Discussion: Our results suggest that cortical atrophy in ADCI and white matter abnormalities in LBCI play important roles in olfactory dysfunction.

Original languageEnglish
Pages (from-to)1243-1252
Number of pages10
JournalAlzheimer's and Dementia
Issue number10
Publication statusPublished - 2018 Oct

Bibliographical note

Funding Information:
Funding Sources: This research was supported by a Faculty research grant from Yonsei University College of Medicine (6-2016-0080) and National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B1015044) and by a grant from Canadian Institute of Health Research (CIHR) awarded to A.C.E. (201085 & 247003). S.J. is the recipient of 2 fellowships that contribute to his support: Bourse Fonds de Recherche Santé Québec (FRQS, dossier 259605) and by Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute (240522).

Publisher Copyright:
© 2018 the Alzheimer's Association

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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