Abstract
Background: Acid suppressing agents are widely used to treat the iatrogenic ulcers following endoscopic mucosal resection for gastric neoplasms. However, the relative merits of proton pump inhibitor or histamine2-receptor antagonist for endoscopic mucosal resection-induced ulcers are not known. Aim: To prospectively compare omeprazole and famotidine for the healing of endoscopic mucosal resection-induced ulcers and for bleeding control. Methods: After endoscopic mucosal resection, patients were randomly assigned to omeprazole (20 mg/day) or to famotidine (40 mg/day) group for a 28-day treatment period. The ulcer sizes and stages, bleeding rates and ulcer-related symptoms were compared. Results: A total of 100 patients were randomized equally to each group. Forty-one patients in each group were finally compared. The two groups were comparable in terms of baseline characteristics. Twenty-eight days after treatment, the two groups were not different with respect to ulcer stage (P = 0.137) or ulcer reduction ratio (P = 0.380). No difference was observed with respect to ulcer-related symptoms (P = 0.437) and no bleeding episode occurred in any of the 82 patients. In subgroup that underwent endoscopic submucosal dissection, fewer patients in the omeprazole group showed active ulcers than those in the famotidine group (P = 0.035). Conclusion: Our results demonstrate that omeprazole may be superior to famotidine for iatrogenic ulcers following endoscopic mucosal resection, especially for large ulcers.
| Original language | English |
|---|---|
| Pages (from-to) | 837-843 |
| Number of pages | 7 |
| Journal | Alimentary Pharmacology and Therapeutics |
| Volume | 24 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2006 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Hepatology
- Gastroenterology
- Pharmacology (medical)
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Omeprazole may be superior to famotidine in the management of iatrogenic ulcer after endoscopic mucosal resection : A prospective randomized controlled trial. / Ye, B. D.; Cheon, J. H.; Choi, K. D.; Kim, S. G.; Kim, J. S.; Jung, H. C.; Song, I. S.
In: Alimentary Pharmacology and Therapeutics, Vol. 24, No. 5, 01.09.2006, p. 837-843.Research output: Contribution to journal › Article
TY - JOUR
T1 - Omeprazole may be superior to famotidine in the management of iatrogenic ulcer after endoscopic mucosal resection
T2 - A prospective randomized controlled trial
AU - Ye, B. D.
AU - Cheon, J. H.
AU - Choi, K. D.
AU - Kim, S. G.
AU - Kim, J. S.
AU - Jung, H. C.
AU - Song, I. S.
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Background: Acid suppressing agents are widely used to treat the iatrogenic ulcers following endoscopic mucosal resection for gastric neoplasms. However, the relative merits of proton pump inhibitor or histamine2-receptor antagonist for endoscopic mucosal resection-induced ulcers are not known. Aim: To prospectively compare omeprazole and famotidine for the healing of endoscopic mucosal resection-induced ulcers and for bleeding control. Methods: After endoscopic mucosal resection, patients were randomly assigned to omeprazole (20 mg/day) or to famotidine (40 mg/day) group for a 28-day treatment period. The ulcer sizes and stages, bleeding rates and ulcer-related symptoms were compared. Results: A total of 100 patients were randomized equally to each group. Forty-one patients in each group were finally compared. The two groups were comparable in terms of baseline characteristics. Twenty-eight days after treatment, the two groups were not different with respect to ulcer stage (P = 0.137) or ulcer reduction ratio (P = 0.380). No difference was observed with respect to ulcer-related symptoms (P = 0.437) and no bleeding episode occurred in any of the 82 patients. In subgroup that underwent endoscopic submucosal dissection, fewer patients in the omeprazole group showed active ulcers than those in the famotidine group (P = 0.035). Conclusion: Our results demonstrate that omeprazole may be superior to famotidine for iatrogenic ulcers following endoscopic mucosal resection, especially for large ulcers.
AB - Background: Acid suppressing agents are widely used to treat the iatrogenic ulcers following endoscopic mucosal resection for gastric neoplasms. However, the relative merits of proton pump inhibitor or histamine2-receptor antagonist for endoscopic mucosal resection-induced ulcers are not known. Aim: To prospectively compare omeprazole and famotidine for the healing of endoscopic mucosal resection-induced ulcers and for bleeding control. Methods: After endoscopic mucosal resection, patients were randomly assigned to omeprazole (20 mg/day) or to famotidine (40 mg/day) group for a 28-day treatment period. The ulcer sizes and stages, bleeding rates and ulcer-related symptoms were compared. Results: A total of 100 patients were randomized equally to each group. Forty-one patients in each group were finally compared. The two groups were comparable in terms of baseline characteristics. Twenty-eight days after treatment, the two groups were not different with respect to ulcer stage (P = 0.137) or ulcer reduction ratio (P = 0.380). No difference was observed with respect to ulcer-related symptoms (P = 0.437) and no bleeding episode occurred in any of the 82 patients. In subgroup that underwent endoscopic submucosal dissection, fewer patients in the omeprazole group showed active ulcers than those in the famotidine group (P = 0.035). Conclusion: Our results demonstrate that omeprazole may be superior to famotidine for iatrogenic ulcers following endoscopic mucosal resection, especially for large ulcers.
UR - http://www.scopus.com/inward/record.url?scp=33747359625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747359625&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2036.2006.03050.x
DO - 10.1111/j.1365-2036.2006.03050.x
M3 - Article
C2 - 16918888
AN - SCOPUS:33747359625
VL - 24
SP - 837
EP - 843
JO - Alimentary Pharmacology and Therapeutics
JF - Alimentary Pharmacology and Therapeutics
SN - 0269-2813
IS - 5
ER -