On-chip plasmonic detection of microRNA-106a in gastric cancer using hybridized gold nanoparticles

Sang Heon Park, Jihye Lee, Jong-Souk Yeo

Research output: Contribution to journalArticle

Abstract

For the early detection of miRNA-106a, the promising biomarker of gastric cancer, we demonstrate on-chip colorimetric biosensing platform based on the plasmon coupling of hybridized gold nanoparticles. Uniform and reproducible substrates are developed by optimizing the distribution and density of core gold nanoparticles with controlled ratio of organosilanes for optical on-chip detection. The core-satellite nanostructure is made by a conjugation between miRNA-106a and probes functionalized on gold nanoparticles, thus enabling the observation of scattering color changes and spectral shift by plasmon coupling effect with high specificity and sensitivity.

Original languageEnglish
Pages (from-to)703-709
Number of pages7
JournalSensors and Actuators, B: Chemical
Volume262
DOIs
Publication statusPublished - 2018 Jun 1

Fingerprint

MicroRNAs
Gold
cancer
chips
gold
Nanoparticles
nanoparticles
biomarkers
Biomarkers
conjugation
Nanostructures
platforms
Satellites
Scattering
Color
color
probes
sensitivity
shift
Substrates

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

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On-chip plasmonic detection of microRNA-106a in gastric cancer using hybridized gold nanoparticles. / Park, Sang Heon; Lee, Jihye; Yeo, Jong-Souk.

In: Sensors and Actuators, B: Chemical, Vol. 262, 01.06.2018, p. 703-709.

Research output: Contribution to journalArticle

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