For the early detection of miRNA-106a, the promising biomarker of gastric cancer, we demonstrate on-chip colorimetric biosensing platform based on the plasmon coupling of hybridized gold nanoparticles. Uniform and reproducible substrates are developed by optimizing the distribution and density of core gold nanoparticles with controlled ratio of organosilanes for optical on-chip detection. The core-satellite nanostructure is made by a conjugation between miRNA-106a and probes functionalized on gold nanoparticles, thus enabling the observation of scattering color changes and spectral shift by plasmon coupling effect with high specificity and sensitivity.
Bibliographical noteFunding Information:
This research was supported by the MSIT(Ministry of Science and ICT), Korea , under the ICT Consilience Creative program(IITP-2017-2017-0-01015) supervised by the IITP(Institute for Information & communications Technology Promotion) and also under the “Mid-career Researcher Program” (NRF-2016R1A2B2014612) supervised by the NRF (National Research Foundation).
© 2018 Elsevier B.V.
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering
- Materials Chemistry