On-Demand Drug Release from Gold Nanoturf for a Thermo- and Chemotherapeutic Esophageal Stent

Sori Lee, Gyoyeon Hwang, Tae Hee Kim, S. Joon Kwon, Jong Uk Kim, Kyongbeom Koh, Byeonghak Park, Haeleen Hong, Ki Jun Yu, Heeyeop Chae, Youngmee Jung, Jiyeon Lee, Tae Il Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Stimuli-responsive delivery systems for cancer therapy have been increasingly used to promote the on-demand therapeutic efficacy of anticancer drugs and, in some cases, simultaneously generate heat in response to a stimulus, resulting in hyperthermia. However, their application is still limited due to the systemic drawbacks of intravenous delivery, such as rapid clearance from the bloodstream and the repeat injections required for sustained safe dosage, which can cause overdosing. Here, we propose a gold (Au)-coated nanoturf structure as an implantable therapeutic interface for near-infrared (NIR)-mediated on-demand hyperthermia chemotherapy. The Au nanoturf possessed long-lasting doxorubicin (DOX) duration, which helps facilitate drug release in a sustained and prolonged manner. Moreover, the Au-coated nanoturf provides reproducible hyperthermia induced by localized surface plasmon resonances under NIR irradiation. Simultaneously, the NIR-mediated temperature increase can promote on-demand drug release at desired time points. For in vivo analysis, the Au nanoturf structure was applied on an esophageal stent, which needs sustained anticancer treatment to prevent tumor recurrence on the implanted surface. This thermo- and chemo-esophageal stent induced significant cancer cell death with released drug and hyperthermia. These phenomena were also confirmed by theoretical analysis. The proposed strategy provides a solution to achieve enhanced thermo-/chemotherapy and has broad applications in sustained cancer treatments.

Original languageEnglish
Pages (from-to)6756-6766
Number of pages11
JournalACS Nano
Volume12
Issue number7
DOIs
Publication statusPublished - 2018 Jul 24

Fingerprint

Stents
hyperthermia
Gold
drugs
Chemotherapy
gold
Infrared radiation
cancer
chemotherapy
Pharmaceutical Preparations
stimuli
delivery
Oncology
Surface plasmon resonance
Cell death
Tumors
clearances
surface plasmon resonance
death
Irradiation

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Lee, S., Hwang, G., Kim, T. H., Kwon, S. J., Kim, J. U., Koh, K., ... Kim, T. I. (2018). On-Demand Drug Release from Gold Nanoturf for a Thermo- and Chemotherapeutic Esophageal Stent. ACS Nano, 12(7), 6756-6766. https://doi.org/10.1021/acsnano.8b01921
Lee, Sori ; Hwang, Gyoyeon ; Kim, Tae Hee ; Kwon, S. Joon ; Kim, Jong Uk ; Koh, Kyongbeom ; Park, Byeonghak ; Hong, Haeleen ; Yu, Ki Jun ; Chae, Heeyeop ; Jung, Youngmee ; Lee, Jiyeon ; Kim, Tae Il. / On-Demand Drug Release from Gold Nanoturf for a Thermo- and Chemotherapeutic Esophageal Stent. In: ACS Nano. 2018 ; Vol. 12, No. 7. pp. 6756-6766.
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Lee, S, Hwang, G, Kim, TH, Kwon, SJ, Kim, JU, Koh, K, Park, B, Hong, H, Yu, KJ, Chae, H, Jung, Y, Lee, J & Kim, TI 2018, 'On-Demand Drug Release from Gold Nanoturf for a Thermo- and Chemotherapeutic Esophageal Stent', ACS Nano, vol. 12, no. 7, pp. 6756-6766. https://doi.org/10.1021/acsnano.8b01921

On-Demand Drug Release from Gold Nanoturf for a Thermo- and Chemotherapeutic Esophageal Stent. / Lee, Sori; Hwang, Gyoyeon; Kim, Tae Hee; Kwon, S. Joon; Kim, Jong Uk; Koh, Kyongbeom; Park, Byeonghak; Hong, Haeleen; Yu, Ki Jun; Chae, Heeyeop; Jung, Youngmee; Lee, Jiyeon; Kim, Tae Il.

In: ACS Nano, Vol. 12, No. 7, 24.07.2018, p. 6756-6766.

Research output: Contribution to journalArticle

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T1 - On-Demand Drug Release from Gold Nanoturf for a Thermo- and Chemotherapeutic Esophageal Stent

AU - Lee, Sori

AU - Hwang, Gyoyeon

AU - Kim, Tae Hee

AU - Kwon, S. Joon

AU - Kim, Jong Uk

AU - Koh, Kyongbeom

AU - Park, Byeonghak

AU - Hong, Haeleen

AU - Yu, Ki Jun

AU - Chae, Heeyeop

AU - Jung, Youngmee

AU - Lee, Jiyeon

AU - Kim, Tae Il

PY - 2018/7/24

Y1 - 2018/7/24

N2 - Stimuli-responsive delivery systems for cancer therapy have been increasingly used to promote the on-demand therapeutic efficacy of anticancer drugs and, in some cases, simultaneously generate heat in response to a stimulus, resulting in hyperthermia. However, their application is still limited due to the systemic drawbacks of intravenous delivery, such as rapid clearance from the bloodstream and the repeat injections required for sustained safe dosage, which can cause overdosing. Here, we propose a gold (Au)-coated nanoturf structure as an implantable therapeutic interface for near-infrared (NIR)-mediated on-demand hyperthermia chemotherapy. The Au nanoturf possessed long-lasting doxorubicin (DOX) duration, which helps facilitate drug release in a sustained and prolonged manner. Moreover, the Au-coated nanoturf provides reproducible hyperthermia induced by localized surface plasmon resonances under NIR irradiation. Simultaneously, the NIR-mediated temperature increase can promote on-demand drug release at desired time points. For in vivo analysis, the Au nanoturf structure was applied on an esophageal stent, which needs sustained anticancer treatment to prevent tumor recurrence on the implanted surface. This thermo- and chemo-esophageal stent induced significant cancer cell death with released drug and hyperthermia. These phenomena were also confirmed by theoretical analysis. The proposed strategy provides a solution to achieve enhanced thermo-/chemotherapy and has broad applications in sustained cancer treatments.

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